Results 81 to 90 of about 12,439 (207)

In Situ Programmable Modulation of Hydrogel Stiffness for Stage‐Adaptive Bone Regeneration

Advanced Science, EarlyView.
Near‐infrared (NIR) irradiation triggers Ca2+ release from thermoresponsive nanocarriers, enabling in situ stiffening of an adaptive hydrogel from a soft to a stiff state, thereby sequentially supporting mesenchymal stromal cell stemness and osteogenic differentiation for stage‐adaptive bone regeneration.
Yuxin Yang, Fan Yang, Lu Wang, Zongtai Li, Weichang Li, Xinchun Zhang   +5 more
wiley   +1 more source

Bioadhesive‐Integrated 3D‐Printed Multilayer Scaffolds Secure a Mechanically‐Stable Osteoimmune Niche for Enhanced Bone Augmentation

Advanced Science, EarlyView.
A 3D‑printed multilayer adhesive scaffold, firmly anchored to bone defects by simple finger pressing, suppresses micromotion and secures mechanical stability of the osteogenic niche. This stabilization likely contributes to the enhanced bone augmentation by fostering a pro‑regenerative mechano‐immune profile—characterized by M2‑like macrophage ...
Delu Zhao, Qiuyi Li, Lingyun Wang, Chongao Zhang, Yutian Cheng, Shuang Liu, Fulan Wei, Zheqin Dong   +7 more
wiley   +1 more source

Cell motion and mechanobiology

Molecular Biology of the Cell, 2015
Diverse new and stimulating results at the interfaces between cell and molecular biology and biophysics were presented in this session cochaired by Ewa Paluch (University College London) and Dennis Discher (University of Pennsylvania). A number of physical features of the cell and its microenvironment were shown to impact the functions and fates of ...
Paluch, Ewa K., Discher, Dennis E.
openaire   +2 more sources

Dielectric Elastomer Actuators as Safe and Effective Tools for Mechanostimulation of Human Cells

Advanced Intelligent Systems, EarlyView.
Replicating physiological forces is crucial for realistic cell models. Dielectric elastomer actuators (DEAs) offer a soft alternative, though their high voltages raised toxicity concerns. We demonstrate that DEA stimulation causes no cell damage, cell death or cell‐cycle disruption, while activating mechanosensitive responses.
Simon Holzer, Chaimae Bahou, Noe Syfrig, Katia Monastyrskaya, Yoan Civet, Ali Hashemi Gheinani, Yves Perriard   +6 more
wiley   +1 more source

Talin1 Adhesion Morphology and Colocalization With Tensin3 Are Largely Unaffected by Polyacrylamide Substrate Stiffness

Cytoskeleton, EarlyView.
ABSTRACT Cells sense the stiffness of their extracellular matrix (ECM) and adapt their behavior accordingly. We investigated how ECM stiffness affects the spatial organization of talin1, a key mechanosensitive focal adhesion protein. Using polyacrylamide (PA) hydrogels with tunable stiffnesses (0.2–188 kPa), we analyzed cell morphology, migration ...
Joanna Hajduk, Patrycja Twardawa, Sylwia Bobis‐Wozowicz, Marta Szewczyk, Zenon Rajfur, Zbigniew Baster   +5 more
wiley   +1 more source

Association between tensin 1 and p130Cas at focal adhesions links actin inward flux to cell migration

Biology Open, 2016
Cell migration is a highly dynamic process that plays pivotal roles in both physiological and pathological processes. We have previously reported that p130Cas supports cell migration through the binding to Src as well as phosphorylation-dependent ...
Zhihai Zhao, Song Hui Tan, Hiroaki Machiyama, Keiko Kawauchi, Keigo Araki, Hiroaki Hirata, Yasuhiro Sawada   +6 more
doaj   +1 more source

Engineered 3D cultured human nasal mucosa mesenchymal stem cell derived sEVs for targeted brain‐derived neurotrophic factor delivery to enhance neurogenesis and attenuate brain damage

Interdisciplinary Medicine, EarlyView.
This study successfully developed and evaluated BDNF@RVG‐sEVs, a novel brain‐targeted nanomedicine based on hnmMSC‐derived sEVs, designed to overcome the BBB and enhance neurorestoration. By integrating RVG for enhanced brain targeting and encapsulating BDNF for potent neurorepair, our system address the key limitations of the conventional sEVs and ...
Xueting Wang, Junge Chen, Jiao Xia, Weitong Yang, Teng Ma, Tianzi Shan, Weifeng He, Gaoman Zhang, Zhuoran Xia, Weiwei Wang, Zhusheng Liu, Zhiqiang Yi, Piye Niu, Tian Chen   +13 more
wiley   +1 more source

Regeneration of the semitendinosus tendon and muscle after isolated semitendinosus harvest for primary anterior cruciate ligament reconstruction: A systematic review

Knee Surgery, Sports Traumatology, Arthroscopy, EarlyView.
Abstract Purpose To systematically evaluate the morphology, temporal evolution and musculoskeletal adaptations associated with semitendinosus tendon (ST) and muscle (SM) regeneration after isolated ST autograft harvest for primary anterior cruciate ligament reconstruction (ACLR).
Maximilian Heinz, Jonathan Lettner, Hassan Tarek Hakam, Nikolai Ramadanov, Maciej Daszkiewicz, Robert Prill, Roland Becker, Laura Schaefer   +7 more
wiley   +1 more source

Mechanical Properties and Testing Strategies for Two‐Photon Lithography: A Review of Current Practices and Emerging Challenges

Laser &Photonics Reviews, EarlyView.
Two‐photon lithography enables the fabrication of complex 3D microstructures with tunable mechanical properties spanning from soft hydrogels to rigid hybrid networks. This review summarizes how material composition, printing parameters, and post‐processing govern stiffness and viscoelasticity, highlighting advanced characterization methods and emerging
Dalila Fontana, Edoardo Rossi, Marco Sebastiani, Edoardo Bemporad, Angelo Accardo, Alberto Rainer, Enrico D. Lemma   +6 more
wiley   +1 more source

Multidimensional excavation of the current status and trends of mechanobiology in cardiovascular homeostasis and remodeling within 20 years

Mechanobiology in Medicine
Mechanobiology is essential for cardiovascular structure and function and regulates the normal physiological and pathological processes of the cardiovascular system.
Wei Liao, Yuxi Huang, Xiangxiu Wang, Ziqiu Hu, Chuanrong Zhao, Guixue Wang   +5 more
doaj   +1 more source