Results 81 to 90 of about 18,551 (276)
Development of Human Stem Cell-Based Model for Developmental Toxicity Testing [PDF]
, 2015 Ph.DPH.D.
XING JIANGWA
core
Advanced Science, EarlyView.Matrix stiffness softening is identified as a previously underappreciated feature in deep caries. Higher stiffness drives exosome release in dental pulp stem cells through a coordinated mechanism involving PI3K–AKT‐regulated Baiap2 and kinesin‐1, thereby promoting odontogenic differentiation.
Bilun Jin +10 more
wiley +1 more source
Paxillin?s Nuclear Transport depends upon Focal Adhesion Dynamics and Interactions with the LD4 Binding Region of FAT Domains [PDF]
, 2014 Ph.DPH.D.
ANEESH SATHE
core
Pharmaceuticals, 2020 Breast cancer progression is marked by cancer cell invasion and infiltration, which can be closely linked to sites of tumor-connected basement membrane thinning, lesion, or infiltration.
Tabea Wiedenhoeft +6 more
doaj +1 more source
In Situ Programmable Modulation of Hydrogel Stiffness for Stage‐Adaptive Bone Regeneration
Advanced Science, EarlyView.Near‐infrared (NIR) irradiation triggers Ca2+ release from thermoresponsive nanocarriers, enabling in situ stiffening of an adaptive hydrogel from a soft to a stiff state, thereby sequentially supporting mesenchymal stromal cell stemness and osteogenic differentiation for stage‐adaptive bone regeneration.
Yuxin Yang +5 more
wiley +1 more source
Advanced Science, EarlyView.The iLEAP technique integrates high‐throughput two‐photon lithography with extrusion printing, bridging sub‐micrometer precision and macroscopic scaffold fabrication. By employing a low‐exothermic photoinitiator, it mitigates thermal damage to biopolymers and preserves bioactivity.
Qifeng Guan +11 more
wiley +1 more source
Advanced Science, EarlyView.A 3D‑printed multilayer adhesive scaffold, firmly anchored to bone defects by simple finger pressing, suppresses micromotion and secures mechanical stability of the osteogenic niche. This stabilization likely contributes to the enhanced bone augmentation by fostering a pro‑regenerative mechano‐immune profile—characterized by M2‑like macrophage ...
Delu Zhao +7 more
wiley +1 more source
Advanced Science, EarlyView.Given that PEEK chest wall implants induce shear force at the soft tissue‐implant interface due to respiratory motion in the early in vivo post‐implantation stage. We confirmed that this mechanical stimulus triggers the PIEZO1/ITGB1/YAP1 signalling axis in L929 and the STAT6/p‐STAT6 pathway in RAW264.7, which in turn mediates adhesion and migration of ...
Rou Huang +14 more
wiley +1 more source
Micropillar substrates: a tool for studying cell mechanobiology.
, 2014 International audienceIncreasing evidence has shown that mechanical cues from the environment play an important role in cell biology. Mechanotransduction or the study of how cells can sense these mechanical cues, and respond to them, is an active field ...
Kocgozlu, Leyla +11 more
core +1 more source