Results 71 to 80 of about 35,268 (338)

Numerical Accuracy Comparison of Two Boundary Conditions Commonly used to Approximate Shear Stress Distributions in Tissue Engineering Scaffolds Cultured under Flow Perfusion

, 2018
Flow-induced shear stresses have been found to be a stimulatory factor in pre-osteoblastic cells seeded in 3D porous scaffolds and cultured under continuous flow perfusion.
Alam, Ali, Alvarez-Barreto, Bacabac, Bakker, Bergemann, Bhatnagar, Black, Brindley, Campos Marin, Chen, Cioffi, Cioffi, Delloye, Efendiev, Graham, Guyot, Guyot, Habashi, Hendrikson, Hossain, Jungreuthmayer, Kim, Kim, Lakhotia, Liu, Maes, Maes, Miyashita, Olivares, Ozgumus, Papavassiliou, Pham, Pham, Porter, Qian, Raimondi, Shakhawath Hossain, Sikavitsas, Simmons, Stolberg, Sukop, Towns, Van Bael, VanGordon, Verbruggen, Voronov, Voronov, Voronov, Voronov, Wang, Williams, Wu, Wyllie, Yourek, Zermatten, Zhao   +56 more
core   +1 more source

Insight into muscle stem cell regeneration and mechanobiology

Stem cell research & therapeutics, 2023
Stem cells possess the unique ability to differentiate into specialized cell types. These specialized cell types can be used for regenerative medicine purposes such as cell therapy.
K. Pang, L. S. Loo, Sean Chia, Francesca Yi Teng Ong, Hanry Yu, Ian Walsh   +5 more
semanticscholar   +1 more source

Computational Modeling Meets 3D Bioprinting: Emerging Synergies in Cardiovascular Disease Modeling

Advanced Healthcare Materials, EarlyView.
Emerging advances in three‐dimensional bioprinting and computational modeling are reshaping cardiovascular (CV) research by enabling more realistic, patient‐specific tissue platforms. This review surveys cutting‐edge approaches that merge biomimetic CV constructs with computational simulations to overcome the limitations of traditional models, improve ...
Tanmay Mukherjee, Mehdi Salar Amoli, Sarah Rezapourdamanab, Lama Rita El Shammas, Martin L. Tomov, Emilio A. Mendiola, Vahid Serpooshan, Reza Avazmohammadi   +7 more
wiley   +1 more source

Surface mechanics and compressive stress impact mammalian follicle development

Nature Communications
The maturation of functional eggs in ovaries is essential for successful reproduction in mammals. Despite its biological and clinical importance, the underlying mechanisms regulating folliculogenesis remain enigmatic.
Arikta Biswas, Yuting Lou, Boon Heng Ng, Kosei Tomida, Sukhada Darpe, Kim Whye Leong, Zihao Wu, Thong Beng Lu, Xiang Teng, Yusuke Toyama, Isabelle Bonne, Chii Jou Chan   +11 more
doaj   +1 more source

The mechanical response of talin

Nature Communications, 2016
Talin is a mechanosensing cytoplasmic adaptor that links integrin cell adhesion receptors to the actin cytoskeleton. Here the authors measure the force-dependent folding and refolding kinetics of all talin rod domains to propose that talin can function ...
Mingxi Yao, Benjamin T. Goult, Benjamin Klapholz, Xian Hu, Christopher P. Toseland, Yingjian Guo, Peiwen Cong, Michael P. Sheetz, Jie Yan   +8 more
doaj   +1 more source

Single cell imaging-based chromatin biomarkers for tumor progression

Scientific Reports, 2021
Tumour progression within the tissue microenvironment is accompanied by complex biomechanical alterations of the extracellular environment. While histopathology images provide robust biochemical markers for tumor progression in clinical settings, a ...
Saradha Venkatachalapathy, Doorgesh S. Jokhun, Madhavi Andhari, G. V. Shivashankar   +3 more
doaj   +1 more source

Mechanical stimulation devices for mechanobiology studies: a market, literature, and patents review

Bio-Design and Manufacturing, 2023
Significant advancements in various research and technological fields have contributed to remarkable findings on the physiological dynamics of the human body.
F. Melo-Fonseca, Ó. Carvalho, M. Gasik, G. Miranda, F. S. Silva   +4 more
semanticscholar   +1 more source

The Floor‐Ceiling‐Chip, or 2 × 2D = Pseudo‐3D—Approaching 3D Cell Morphology and Organization between Two Opposing 2D Substrates with Cell‐Adhesive Protein Micropatterns

Advanced Healthcare Materials, EarlyView.
Here, we present a novel 3D cell patterning and culture platform. The “Floor‐Ceiling‐Chip” (FC‐Chip) consists of two opposing track‐etched membranes, creating a pseudo‐3D microenvironment for the cells in between. By providing the membranes with micropatterned cell‐adhesive islands of varying geometries and sizes, the FC‐Chip enables control over cell ...
Urandelger Tuvshindorj, Francesca Giacomini, Esra Güben Kaçmaz, Tim ten Brink, Lorenzo Moroni, Zeinab Tahmasebi Birgani, Clemens van Blitterswijk, Pamela Habibović, Stefan Giselbrecht, Jan de Boer, Roman Truckenmüller   +10 more
wiley   +1 more source

DNA damage causes rapid accumulation of phosphoinositides for ATR signaling

Nature Communications, 2017
Phosphoinositides are enriched in the nucleus and accumulate upon DNA damage but their role in responding to DNA damage is poorly defined. Here, the authors show that phosphoinositides rapidly accumulate at DNA damage sites and are required for ATR ...
Yu-Hsiu Wang, Anushya Hariharan, Giulia Bastianello, Yusuke Toyama, G. V. Shivashankar, Marco Foiani, Michael P. Sheetz   +6 more
doaj   +1 more source

A level-set method for the evolution of cells and tissue during curvature-controlled growth

, 2019
Most biological tissues grow by the synthesis of new material close to the tissue's interface, where spatial interactions can exert strong geometric influences on the local rate of growth.
Guyot Y, LeFloch PG, Press WH, Sethian JA, Vermolen F   +4 more
core   +1 more source