Results 51 to 60 of about 12,439 (207)
npj Biological Physics and MechanicsThe eye presents a very dynamic biomechanical environment, and thus ocular cells must be highly mechanosensitive and mechanoresponsive. Moreover, defects in mechanobiological pathways contribute to a number of sight-threatening ocular diseases, highlighting the importance of ocular mechanobiology.
Ethier, C. Ross, Herberg, Samuel
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Mechanobiology research in China
Mechanobiology in Medicine, 2023 Mechanobiology is an interdisciplinary discipline combining biology, engineering, chemistry, physics, and medicine. Mechanobiology research comprehensively discusses, the role of mechanical factors in various life processes and the occurrence and development of associated and diseases at the whole organism, organ, cell, protein and gene levels.
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On the generation of force required for actin-based motility
Scientific ReportsThe fundamental question of how forces are generated in a motile cell, a lamellipodium, and a comet tail is the subject of this note. It is now well established that cellular motility results from the polymerization of actin, the most abundant protein in
Alberto Salvadori +3 more
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Emergent patterns of collective cell migration under tubular confinement
Nature Communications, 2017 Collective epithelial behaviours are studied in vitro in the context of flat sheets but a system to mimic tubular systems is lacking. Here, the authors develop a method to study collective behaviour in lumenal structures and show that several features ...
Wang Xi +4 more
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Stimuli-responsive biomaterials for cardiac tissue engineering and dynamic mechanobiology
APL Bioengineering, 2021 Since the term “smart materials” was put forward in the 1980s, stimuli-responsive biomaterials have been used as powerful tools in tissue engineering, mechanobiology, and clinical applications.
Huaiyu Shi, Chenyan Wang, Zhen Ma
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Advanced Materials Interfaces, EarlyView.Dynamic mechanical loading of outer meniscus fibrochondrocytes increases extracellular vesicle (EV) yield and alters EV composition. When applied to progenitor cells, these mechanically primed EVs modulate the expression of matrix‐related genes.
Catherine Cheung +6 more
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Mechanobiology of the Nucleolus
Biology of the CellABSTRACT Ribosome biogenesis is an essential and energy‐demanding process required to maintain cellular proteostasis. The nucleolus, which orchestrates this vital process, assembles as a nuclear condensate and exhibits remarkable plasticity in its structure, function, and protein composition.
Yuthika Shetty, Monika Elzbieta Dolega
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Cell Communication and Signaling, 2020 Background The electromechanical function of myocardial tissue depends on the intercellular communication between cardiomyocytes (CMs) as well as their crosstalk with other cell types.
Krishna Chander Sridhar +4 more
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Advanced Science, EarlyView.In this research article, Mansoor and coworkers present a novel device that applies controlled mechanical stimuli to cardiomyocytes using pressure‐driven membrane deformation. By exposing cells to physiologically and pathologically relevant loading conditions, the platform reproduces distinct structural, functional and molecular responses associated ...
Haris Mansoor +11 more
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Mechanobiology of cardiomyocyte development [PDF]
Journal of Biomechanics, 2010 Cardiac cells are under constant, self-generated mechanical stress which can affect the differentiation of stem cells into cardiac myocytes, the development of differentiated cells and the maturation of cells in neonatal mammals. In this article, the effects of direct stretch, electrically induced beating and substrate elasticity on the behavior and ...
Jeffrey G, Jacot +2 more
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