Results 51 to 60 of about 18,551 (276)
DNA damage causes rapid accumulation of phosphoinositides for ATR signaling
Nature Communications, 2017 Phosphoinositides are enriched in the nucleus and accumulate upon DNA damage but their role in responding to DNA damage is poorly defined. Here, the authors show that phosphoinositides rapidly accumulate at DNA damage sites and are required for ATR ...
Yu-Hsiu Wang +6 more
doaj +1 more source
Integrin-Matrix Clusters Form Podosome-like Adhesions in the Absence of Traction Forces
Cell Reports, 2013 Matrix-activated integrins can form different adhesion structures. We report that nontransformed fibroblasts develop podosome-like adhesions when spread on fluid Arg-Gly-Asp peptide (RGD)-lipid surfaces, whereas they habitually form focal adhesions on ...
Cheng-han Yu +6 more
doaj +1 more source
Advanced Materials, EarlyView.A chemically defined PEG‐based microgel platform enables scalable, reproducible production of three‐dimensional microgel‐iPSC constructs in multiple sizes. The system is compatible with high‐throughput automation and supports human iPSC expansion and differentiation within a single construct, including directed differentiation into cardiac organoids ...
Laura Klasen +8 more
wiley +1 more source
Mechanobiology research in China
Mechanobiology in Medicine, 2023 Mechanobiology is an interdisciplinary discipline combining biology, engineering, chemistry, physics, and medicine. Mechanobiology research comprehensively discusses, the role of mechanical factors in various life processes and the occurrence and development of associated and diseases at the whole organism, organ, cell, protein and gene levels.
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Mechanobiology of cardiomyocyte development [PDF]
Journal of Biomechanics, 2010 Cardiac cells are under constant, self-generated mechanical stress which can affect the differentiation of stem cells into cardiac myocytes, the development of differentiated cells and the maturation of cells in neonatal mammals. In this article, the effects of direct stretch, electrically induced beating and substrate elasticity on the behavior and ...
Jeffrey G, Jacot +2 more
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Programmable Pneumatic Actuator System for a Bioinspired Artificial Colon
Advanced Materials Technologies, EarlyView.A modular soft robotic colon simulator driven by programmable pneumatic actuation is developed to mimic physiological and pathological‐like motility patterns of the large intestine. Finite element–guided design and distributed control enable anatomically realistic deformation for peristalsis, segmentation, and mass movements, supporting capsule ...
Andrew Bickerdike +6 more
wiley +1 more source
The mechanical response of talin
Nature Communications, 2016 Talin is a mechanosensing cytoplasmic adaptor that links integrin cell adhesion receptors to the actin cytoskeleton. Here the authors measure the force-dependent folding and refolding kinetics of all talin rod domains to propose that talin can function ...
Mingxi Yao +8 more
doaj +1 more source
A Toolbox for Organelle Mechanobiology Research—Current Needs and Challenges
Micromachines, 2019 Mechanobiology studies from the last decades have brought significant insights into many domains of biological research, from development to cellular signaling.
Qian Feng +2 more
doaj +1 more source
Mechanobiology in Cells and Tissues
International Journal of Molecular Sciences, 2023 This Editorial is a comment on the success of the Special Issue “Mechanobiology in Cells and Tissues” published in the International Journal of Molecular Sciences [...]
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Engineered hydrogels for mechanobiology
Nature Reviews Methods Primers, 2022 Cells' local mechanical environment can be as important in guiding cellular responses as many well-characterized biochemical cues. Hydrogels that mimic the native extracellular matrix can provide these mechanical cues to encapsulated cells, allowing for the study of their impact on cellular behaviours.
Ulrich Blache +8 more
openaire +2 more sources