Results 121 to 130 of about 18,551 (276)

Musculoskeletal mechanobiology [PDF]

Connective Tissue Research, 2021
openaire   +2 more sources

Talin1 Adhesion Morphology and Colocalization With Tensin3 Are Largely Unaffected by Polyacrylamide Substrate Stiffness

Cytoskeleton, EarlyView.
ABSTRACT Cells sense the stiffness of their extracellular matrix (ECM) and adapt their behavior accordingly. We investigated how ECM stiffness affects the spatial organization of talin1, a key mechanosensitive focal adhesion protein. Using polyacrylamide (PA) hydrogels with tunable stiffnesses (0.2–188 kPa), we analyzed cell morphology, migration ...
Joanna Hajduk, Patrycja Twardawa, Sylwia Bobis‐Wozowicz, Marta Szewczyk, Zenon Rajfur, Zbigniew Baster   +5 more
wiley   +1 more source

ROLE OF FORMIN FHOD1 IN THE ACTIN PEDESTAL FORMATION

, 2017
Ph.DPH.D.
MRINAL SHAH
core  

Engineered 3D cultured human nasal mucosa mesenchymal stem cell derived sEVs for targeted brain‐derived neurotrophic factor delivery to enhance neurogenesis and attenuate brain damage

Interdisciplinary Medicine, EarlyView.
This study successfully developed and evaluated BDNF@RVG‐sEVs, a novel brain‐targeted nanomedicine based on hnmMSC‐derived sEVs, designed to overcome the BBB and enhance neurorestoration. By integrating RVG for enhanced brain targeting and encapsulating BDNF for potent neurorepair, our system address the key limitations of the conventional sEVs and ...
Xueting Wang, Junge Chen, Jiao Xia, Weitong Yang, Teng Ma, Tianzi Shan, Weifeng He, Gaoman Zhang, Zhuoran Xia, Weiwei Wang, Zhusheng Liu, Zhiqiang Yi, Piye Niu, Tian Chen   +13 more
wiley   +1 more source

STUDY OF COLLECTIVE CELL MIGRATION IN DROSOPHILA MIDDLE OOGENESIS

, 2016
Ph.DPH.D.
LEI QIN
core  

Cellular Responses to Mechanical Cues Across Scales: From Fundamental Insights to Translational Potential. [PDF]

Adv Healthc Mater
This review examines how cellular behavior is regulated by mechanical cues transmitted through soft biomaterials, from single‐cell mechanosensing to tissue‐level adaptation. It highlights why physiological relevance, rather than model complexity alone, is critical for translational mechanobiology and introduces a scoring framework linking material ...
Polz M, Kainz MP, Haider N, Rienmüller T, Lenk K, Kargl R, Terzano M, Sommer G, Holzapfel GA, Fuchs J.   +9 more
europepmc   +2 more sources

Regeneration of the semitendinosus tendon and muscle after isolated semitendinosus harvest for primary anterior cruciate ligament reconstruction: A systematic review

Knee Surgery, Sports Traumatology, Arthroscopy, EarlyView.
Abstract Purpose To systematically evaluate the morphology, temporal evolution and musculoskeletal adaptations associated with semitendinosus tendon (ST) and muscle (SM) regeneration after isolated ST autograft harvest for primary anterior cruciate ligament reconstruction (ACLR).
Maximilian Heinz, Jonathan Lettner, Hassan Tarek Hakam, Nikolai Ramadanov, Maciej Daszkiewicz, Robert Prill, Roland Becker, Laura Schaefer   +7 more
wiley   +1 more source

INVESTIGATION OF REGULATORY MECHANISM OF DNA HOMOLOGOUS RECOMBINATION REPAIR AT SINGLE MOLECULAR LEVEL

, 2017
Ph.DPH.D.
CHEN JIN
core  

Polymer model integrates imaging and sequencing to reveal how nanoscale heterochromatin domains influence gene expression

Nature Communications
Chromatin organization regulates gene expression, with nanoscale heterochromatin domains playing a fundamental role. Their size varies with microenvironmental stiffness and epigenetic interventions, but how these factors regulate their formation and ...
Vinayak Vinayak, Ramin Basir, Rosela Golloshi, Joshua Toth, Lucas Sant’Anna, Melike Lakadamyali, Rachel Patton McCord, Vivek B. Shenoy   +7 more
doaj   +1 more source

Construction optimization and functional applications of fluorescent nanodiamonds

Responsive Materials, EarlyView.
This review summarizes synthesis, surface modification and optical properties of fluorescent nanodiamonds. Their advances in quantum sensing, single‐photon emission and biomedicine are discussed, and existing challenges and future directions are presented.
Yunpeng Yang, Sen Zhang, Chao Chen, Wensi Yang, Zuanquan Chen, Rui Fan, Linlin Liu, Benjian Liu, Kang Liu, Zhibo Zhang, Bing Dai, Jiaqi Zhu   +11 more
wiley   +1 more source