Results 121 to 130 of about 35,268 (338)
On the Role of Mechanics in Chronic Lung Disease. [PDF]
, 2013 Progressive airflow obstruction is a classical hallmark of chronic lung disease, affecting more than one fourth of the adult population. As the disease progresses, the inner layer of the airway wall grows, folds inwards, and narrows the lumen.
Eskandari, Mona +2 more
core +3 more sources
All-optical mechanobiology interrogation of YAP in human cancer and normal cells using a novel multi-functional system [PDF]
, 2021 Qin Luo +10 more
openalex +1 more source
Mechanobiology of 3D cell confinement and extracellular crowding
Biophysical ReviewsCells and tissues are often under some level of confinement, imposed by the microenvironment and neighboring cells, meaning that there are limitations to cell size, volume changes, and fluid exchanges.
Gabriela Da Silva André +1 more
semanticscholar +1 more source
Advanced Science, EarlyView.Prolonged exposure to stiff extracellular matrix drives cancer‐associated fibroblasts into a persistently activated myofibroblast state. Two parallel pathways are identified: β1 integrin activation smoothens the nuclear lamina to reduce lamin–chromatin contacts, while the formin mDia2 regulates nuclear actin to alter chromatin organization.
Swathi Packirisamy +4 more
wiley +1 more source
Advanced Science, EarlyView.Producing MSCs on rigid culture substrates induces a scar‐making phenotype, jeapordizing therapeutic success. ‘Tissue‐soft’ surfaces prevent MSC fibrogenesis and preserve regenerative traits. An epigenetic network, driven by HOXA11 and SALL1, maintains ‘soft memory’ by keeping chromatin open in relaxed MSCs, promoting anti‐fibrotic programs.
Fereshteh Sadat Younesi +7 more
wiley +1 more source
Predicting cortical bone adaptation to axial loading in the mouse tibia [PDF]
, 2015 The development of predictive mathematical models can contribute to a deeper understanding of the specific stages of bone mechanobiology and the process by which bone adapts to mechanical forces.
A. A. Pitsillides +9 more
core +3 more sources
The mechanobiology theory of the development of medical device-related pressure ulcers revealed through a cell-scale computational modeling framework [PDF]
, 2021 Adi Lustig +5 more
openalex +1 more source
Engines of change: Nonmuscle myosin II in mechanobiology.
Current Opinion in Cell BiologyThe emergence of mechanobiology has unveiled complex mechanisms by which cells adjust intracellular force production to their needs. Most communicable intracellular forces are generated by myosin II, an actin-associated molecular motor that transforms ...
Marina Garrido-Casado +3 more
semanticscholar +1 more source
Advanced Science, EarlyView.This study investigates how CTCs survive varying shear stress during hematogenous metastasis. We uncover a self‐protection mechanism, by which non‐adherent CTCs adapt to high shearing milieu through accumulated cytoplasmic myosin‐mediated disruption of myosin‐actin binding, attenuating force transmission into chromatin to protect CTCs from shear ...
Cunyu Zhang +10 more
wiley +1 more source
Lattice and Continuum Modelling of a Bioactive Porous Tissue Scaffold
, 2018 A contemporary procedure to grow artificial tissue is to seed cells onto a porous biomaterial scaffold and culture it within a perfusion bioreactor to facilitate the transport of nutrients to growing cells.
Beliaev, Dmitry +3 more
core