Results 91 to 100 of about 3,360 (286)
Mechanochemically induced solid state transformations: The case of raloxifene hydrochloride
European Journal of Pharmaceutical Sciences, 2018 Raloxifene hydrochloride is a benzothiophene derivative mainly used in the prevention and treatment of osteoporosis, but exhibits a low bioavailability hindered by its poor water solubility. In this study, a mechanochemical approach based on neat and liquid-assisted grinding was applied to produce new solid forms of raloxifene hydrochloride. The solids
Yara Santiago de Oliveira +2 more
openaire +2 more sources
Kinetics of the mechanochemical synthesis of alkaline-earth metal amides
, 2014 A phenomenological framework is developed to model the kinetics of the formation of alkaline-earth metal amides by the ball milling induced reaction of their hydrides with gaseous ammonia.
Takacs L +3 more
core +1 more source
InorganicsThe synthesis of [Cu(PteN˄N)(P˄P)][BF4] complexes with pterin-fused phenanthroline (PteN˄N) derivatives and bisphosphine (P˄P) co-ligands was achieved through a mechanochemical approach. Due to the extremely poor solubility of PteN˄N ligands, traditional
Siva S. M. Bandaru +4 more
doaj +1 more source
The Scientific World Journal, 2018 This study demonstrates the link between the modification of the solid-phase pharmaceutical substances mechanical structure and their activity in waters with different molar ratio «deuterium-protium».
A. V. Syroeshkin +6 more
doaj +1 more source
Mechanochemical and Conformational Study of N-heterocyclic Carbonyl-Oxime Transformations
Croatica Chemica Acta, 2014 New mechanochemical pathways for the transformation of six N-heterocyclic carbonyl compounds into oximes using hydroxylamine hydrochloride were explored. Reactions were performed first without any base since the heterocyclic moieties (imidazole, benzimidazole, pyridine and quinuclidine) have an intrinsic basic nitrogen atom.
Primožič, Ines +5 more
openaire +3 more sources
Overview of milling techniques for improving the solubility of poorly water-soluble drugs
Asian Journal of Pharmaceutical Sciences, 2015 Milling involves the application of mechanical energy to physically break down coarse particles to finer ones and is regarded as a “top–down” approach in the production of fine particles.
Zhi Hui Loh +2 more
doaj +1 more source
Mechanochemical activation of magnetite nanoparticles
, 2000 Using Mössbauer spectroscopy as a function of ball milling time, it was found that nanomagnetite behaves differently than magnetite during mechanochemical activation. The phase sequence is determined by the original particle size of the powder. Magnetite
Monica Sorescu
core
Milling parameter optimization for the refinement of NiO/Al mixtures and the synthesis of Ni/Al2O3 nanocomposites [PDF]
Journal of Mining and Metallurgy. Section B: MetallurgyThis study examined the effects of milling parameters on the development of Ni/Al2O3 nanocomposites and the refinement of NiO and Al powders. Ball milling of certain mixtures was followed by sintering at 800 and 1100 °C for 2 h.
Berramdan N E.H. +4 more
doaj +1 more source
Application of Ball Milling for Highly Selective Mechanochemical Polymorph Transformations
Organic Process Research & Development, 2018 Milling is an important secondary processing technique in the manufacture of pharmaceuticals, primarily used as a particle size reduction process. p-Aminobenzoic acid (PABA), m-aminobenzoic acid (MABA), o-aminobenzoic acid (OABA), and carbamazepine (CBZ) are pharmaceutically relevant compounds that can exist in different polymorphic forms with distinct
Naghmeh Kamali +3 more
openaire +1 more source
Biofuel Production by Fermentation of Water Plants and Agricultural Lignocellulosic by-Products
MATEC Web of Conferences, 2016 While at present most energy crops are depriving human feedstock, fermentation of agricultural residues and fast growing water plants possesses a good prospect to become a significant source for bio-fuel; as both substrates are widely available and do ...
Anker Yaakov +4 more
doaj +1 more source