Results 141 to 150 of about 3,272 (188)
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Failure to Induce Tolerance to Mechlorethamine Hydrochloride
Archives of Dermatology, 1977In view of the contradictory results reported in the literature regarding induction of specific immunologic tolerance to mechlorethamine hydrochloride (HN2), the problem was reinvestigated using a "tolerogenic" schedule that had been reported to be effective.
Rudolf L. Baer +2 more
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Topically Applied Mechlorethamine in the Treatment of Psoriasis
Archives of Dermatology, 1971The psoriatic lesions of seven male patients were treated with a daily topical application of 10 mg of mechlorethamine hydrochloride in 50 ml of tap water. All seven patients began to show resolution of the treated lesions within seven days, with essentially complete clearing of the lesions by three weeks.
J. Richard Taylor +2 more
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Particulate Science and Technology, 2020
The present work was aimed to prepare, optimize and characterize nanostructured lipid carriers (NLCs) loaded with mechlorethamine for improvement in pharmacokinetics.
B. Gidwani, A. Vyas, C. Kaur
semanticscholar +1 more source
The present work was aimed to prepare, optimize and characterize nanostructured lipid carriers (NLCs) loaded with mechlorethamine for improvement in pharmacokinetics.
B. Gidwani, A. Vyas, C. Kaur
semanticscholar +1 more source
Studies in the Pharmacodynamics of Mechlorethamine and AB 100
JAMA, 1961ALKYLATING agents have been used in the Ltreatment of neoplastic disease since 1931, when Adair and Bagg 1 described experiences with topical application of sulfur mustard. Intensive investigation during World War II resulted in a greater appreciation of the usefulness of these compounds.
Herman Hagedorn +4 more
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Response of Mycosis Fungoides to Topical Chemotherapy With Mechlorethamine [PDF]
Archives of Dermatology, 1984 Seventy-six patients with mycosis fungoides (MF) were given topical mechlorethamine hydrochloride therapy. Allergic contact hypersensitivity reactions to the drug developed in 51 patients (67.1%). Sixty-four patients of the original 76 continued therapy, with 43 (67.2%) achieving a complete remission and 12 (18.8%) achieving a partial remission.
Robert E. Parnes +2 more
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Counteraction of leukopenia caused by mechlorethamine and azathioprine
Journal of Surgical Oncology, 1971AbstractPCO, a deproteinized yeast extract of low toxicity, increases tissue respiration, offsets the toxicity of mechlorethamine hydrochloride (HN2) for mice with maintenance of antineoplastic activity in the systems studied, and is a useful adjuvant to azathioprine in dog renal allografts. The two latter effects appear to be related to the ability of
Leo G. Nutini, Elton S. Cook
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Intravenous Desensitization to Mechlorethamine in Patients With Psoriasis
Archives of Dermatology, 1976Eight patients with psoriasis who had developed contact allergy to mechlorethamine hydrochloride (nitrogen mustard) were subjected to a regimen of intravenous infusion of small amounts of the drug in an attempt to produce desensitization. Although three of eight developed negative patch tests and were presumed to be desensitized, only one patient was ...
Kenneth M. Halprin +4 more
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Mechlorethamine Desensitization in Therapy for Mycosis Fungoides
Archives of Dermatology, 1975Five patients with mycosis fungoides who had developed contact dermatitis to a nitrogen mustard, mechlorethamine hydrochloride, even in low concentrations (1 to 5 mg/100 ml), received daily total-body applications of extremely dilute solutions (0.01 to 0.1 mg/100 ml) of mechlorethamine.
Zvi Fuks +2 more
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Archives of Surgery, 1964
The use of chemotherapeutic agents as an adjunct to operative management of malignant disease is receiving considerable attention in current cancer research. Since the effects of these highly toxic drugs are not entirely limited to neoplastic tissue, however, knowledge of their effects on normal healing of wounds would be valuable.
Edward T. Krementz +1 more
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The use of chemotherapeutic agents as an adjunct to operative management of malignant disease is receiving considerable attention in current cancer research. Since the effects of these highly toxic drugs are not entirely limited to neoplastic tissue, however, knowledge of their effects on normal healing of wounds would be valuable.
Edward T. Krementz +1 more
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Treatment of Hallopeau's Acrodermatitis With Topical Mechlorethamine
Archives of Dermatology, 1978To the Editor.— The therapy for Hallopeau's acrodermatitis (continua, perstans), which includes the use of common topical antipsoriatic agents like tar, cignolin, and corticosteroids, is mentioned in literature, but the extreme resistance of the disease to any therapy is well known.
Ernst Stolz +2 more
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