Results 141 to 150 of about 3,791 (174)

Ointment-based mechlorethamine treatment for mycosis fungoides

Cancer, 1983
The treatment of skin disease with topical mechlorethamine has been restricted because of the frequent development of contact dermatitis. A series of 43 patients with mycosis fungoides in Stages 1A (17), IB (22), II (2), and III (2) were treated with an ointment-based mechlorethamine, prepared by an anhydrous method.
N M, Price, R T, Hoppe, D G, Deneau
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Topical therapy of psoriasis with mechlorethamine.

Archives of dermatology, 1972
Aqueous solutions of mechlorethamine (Mustargen) hydrochloride (0.055 to 0.00625%) have been used in courses of seven to ten days on lesions of psoriasis in 42 patients. A significant involutionary effect was obtained with the 0.0125% to 0.05% concentrations, particularly on the trunk. The rate of contact sensitization ranged from 50% to more than 80%,
H S, Zackheim, J E, Arnold, E M, Farber, A J, Cox   +3 more
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Bone Marrow Protection in Mechlorethamine (Nitrogen Mustard) Therapy

Archives of Surgery, 1962
The hematologic effects of mechlorethamine hydrochloride (nitrogen mustard) limit the dose employed when this drug is used for chemotherapy of advanced cancer. Although other toxicities are recognized, e.g., of the intestinal and central nervous system, they represent effects at higher dosage levels than are ordinarily used.
D G, MILLER, W, LAWRENCE
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Counteraction of leukopenia caused by mechlorethamine and azathioprine

Journal of Surgical Oncology, 1971
AbstractPCO, a deproteinized yeast extract of low toxicity, increases tissue respiration, offsets the toxicity of mechlorethamine hydrochloride (HN2) for mice with maintenance of antineoplastic activity in the systems studied, and is a useful adjuvant to azathioprine in dog renal allografts. The two latter effects appear to be related to the ability of
E S, Cook, L G, Nutini
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Mechlorethamine Hydrochloride Solutions and Ointment

Archives of Dermatology, 1980
• Solutions of mechlorethamine hydrochloride used to treat patients with mycosis fungoides and psoriasis are stable for many months, especially when they are refrigerated. This fact should make the use of this treatment more convenient. On the other hand, the risk of cancer induction from such use should be appreciated.
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Intrapleural Mechlorethamine Hydrochloride Therapy for Malignant Pleural Effusion

JAMA, 1964
PLEURAL EFFUSION secondary to metastatic malignant disease in pleura is a frequent occurrence. Particularly susceptible patients are those with primary breast cancer. Often the pleural effusion is the most symptomatic evidence of metastases. Systemic hormonal therapy or chemotherapy seldom alleviates the fluid accumulation and local treatment ...
J B, MARK, I S, GOLDENBERG, A C, MONTAGUE   +2 more
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Mechlorethamine-induced enhancement of radiation sensitivity of guanine

International Journal of Radiation Biology, 1996
This study describes and characterizes the interactions of nitrogen mustard mechlorethamine (HN2) with guanine and the radiation sensitivity of guanine in the presence of HN2. Briefly, in an equimolar solution (0.5 mmol dm-3) the pH-dependence (pH 3.0-12.0) and time-dependence (0-36 h) of alkylation of guanine at room temperature were determined using ...
Y N, Vaishnav, C E, Swenberg
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Topical Mechlorethamine

Archives of Dermatology, 1977
Six patients with mycosis fungoides were treated with topical mechlorethamine hydrochloride for periods of two to four years. Clinical and histological studies for radiomimetic and radiodermatitis-like effects failed to demonstrate any abnormalities.
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Hypothermia Against Lethal Dose of Mechlorethamine

Archives of Surgery, 1961
One of the problems involved in regional perfusion for cancer chemotherapy is protection of the bone marrow outside of the perfused area due to "leak" of the antitumor agent from the perfused area. Since in vitro experiments have shown that reduction in incubation temperature below 37 C depresses the antitumor effect of certain alkylating agents ...
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Mechlorethamine desensitization in therapy for mycosis fungoides. Topical desensitization to mechlorethamine (nitrogen mustard) contact hypersensitivity.

Archives of dermatology, 1975
Five patients with mycosis fungoides who had developed contact dermatitis to a nitrogen mustard, mechlorethamine hydrochloride, even in low concentrations (1 to 5 mg/100 ml), received daily total-body applications of extremely dilute solutions (0.01 to 0.1 mg/100 ml) of mechlorethamine.
V S, Constantine, Z Y, Fuks, E M, Farber
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