Results 131 to 140 of about 2,699 (183)

Mortality in Patients With Hodgkin Lymphoma and Heart Failure: A Swedish Population-Based Study. [PDF]

JACC Adv
Godtfredsen SJ, Eloranta S, Smedby KE, Antonilli S, Baech J, Molin D, Kragholm K, El-Galaly TC, Dietrich CE.   +8 more
europepmc   +1 more source

Zeb1 Facilitates Nitrogen Mustard-Induced Corneal Epithelial Wound Healing by Maintaining Epithelial Renewability. [PDF]

Invest Ophthalmol Vis Sci
Wang F, Sun X, Dong Y, Cheng F, Fan J, Lu X, Emery D, Shao H, Wang W, Zhang L, Dean DC, Liu Y.   +11 more
europepmc   +1 more source

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Dysregulation of the mTOR pathway by mechlorethamine

Toxicology, 2023
Mechlorethamine (HN2) is a derivative of the chemical warfare agent sulfur mustard (SM) and cutaneous exposure to HN2 is associated with dermal-epidermal junction (DEJ) disruption (vesication). The primary purpose of the present study was to investigate the effect of HN2 on the mammalian target of rapamycin (mTOR) signaling pathway using an in vivo ...
Trishaal Janardhanam Raghavendra, Rao, Ganming, Mao, Benedette J, Cuffari, Blase, Billack   +3 more
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Hypersensitivity to Mechlorethamine

Annals of Internal Medicine, 1981
Excerpt To the editor: The recently published review by Weiss and Bruno (1) prompts us to report a second case of type 1 hypersensitivity to intravenous mechlorethamine.
KENNETH S. WILSON, SKARIA ALEXANDER
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Accidental intramuscular injection of mechlorethamine

Cancer, 1980
A 55-year-old man with chronic, active diffuse psoriasis was accidentally given 30 mg of mechlorethmine deep into the buttock muscles. About 5 hours after the intramuscular (IM) mechlorethamine injection, 1/6 M sodium thiosulfate was infused around the intramuscular site.
O E, Owen, D L, Dellatorre, E J, Van Scott, M R, Cohen   +3 more
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Hyperbaric Oxygenation and Mechlorethamine Effectiveness

Archives of Surgery, 1963
In order to test one of the possible radiomimetic qualities of alkylating agents, we have studied the influence of hyperbaric oxygen on the tumoricidal action of mechlorethamine (nitrogen mustard) in spontaneous mammary tumors of heterozygous, randomly bred Swiss-Webster mice.
R P, LEATHER, C, ECKERT
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Topical mechlorethamine therapy for mycosis fungoides

British Journal of Dermatology, 1977
Patients with limited skin involvement by mycosis fungoides were treated with daily topical mechlorethamine. Seven of thirteen patients had a complete remission of diseases. Six of these seven experienced a contact dermatitis and four underwent a successful topical desensitization programme.
N M, Price, V S, Constantine, R T, Hoppe, Z Y, Fuks, E M, Farber   +4 more
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Topical Therapy of Psoriasis With Mechlorethamine

Archives of Dermatology, 1972
Aqueous solutions of mechlorethamine (Mustargen) hydrochloride (0.055 to 0.00625%) have been used in courses of seven to ten days on lesions of psoriasis in 42 patients. A significant involutionary effect was obtained with the 0.0125% to 0.05% concentrations, particularly on the trunk. The rate of contact sensitization ranged from 50% to more than 80%,
H S, Zackheim, J E, Arnold, E M, Farber, A J, Cox   +3 more
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Counteraction of leukopenia caused by mechlorethamine and azathioprine

Journal of Surgical Oncology, 1971
AbstractPCO, a deproteinized yeast extract of low toxicity, increases tissue respiration, offsets the toxicity of mechlorethamine hydrochloride (HN2) for mice with maintenance of antineoplastic activity in the systems studied, and is a useful adjuvant to azathioprine in dog renal allografts. The two latter effects appear to be related to the ability of
E S, Cook, L G, Nutini
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NMR studies of the conjugation of mechlorethamine with glutathione

Journal of Medicinal Chemistry, 1990
Many cancer cells are resistant to chemotherapeutic treatment with mechlorethamine and other alkylating agents. These drug-resistant cells often show an increase in the intracellular concentration of glutathione and an increase in the activity of glutathione-S-transferase when compared to the sensitive cells.
M P, Gamcsik, T G, Hamill, M, Colvin
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