Results 141 to 150 of about 2,545 (184)

Topical mechlorethamine therapy for mycosis fungoides

British Journal of Dermatology, 1977
Patients with limited skin involvement by mycosis fungoides were treated with daily topical mechlorethamine. Seven of thirteen patients had a complete remission of diseases. Six of these seven experienced a contact dermatitis and four underwent a successful topical desensitization programme.
N M, Price, V S, Constantine, R T, Hoppe, Z Y, Fuks, E M, Farber   +4 more
openaire   +2 more sources

Studies in the Pharmacodynamics of Mechlorethamine and AB 100

JAMA, 1961
ALKYLATING agents have been used in the Ltreatment of neoplastic disease since 1931, when Adair and Bagg 1 described experiences with topical application of sulfur mustard. Intensive investigation during World War II resulted in a greater appreciation of the usefulness of these compounds.
R K, AUSMAN, G E, CREVAR, H, HAGEDORN, T J, BARDOS, J L, AMBRUS   +4 more
openaire   +2 more sources

Topical Therapy of Psoriasis With Mechlorethamine

Archives of Dermatology, 1972
Aqueous solutions of mechlorethamine (Mustargen) hydrochloride (0.055 to 0.00625%) have been used in courses of seven to ten days on lesions of psoriasis in 42 patients. A significant involutionary effect was obtained with the 0.0125% to 0.05% concentrations, particularly on the trunk. The rate of contact sensitization ranged from 50% to more than 80%,
H S, Zackheim, J E, Arnold, E M, Farber, A J, Cox   +3 more
openaire   +3 more sources

Counteraction of leukopenia caused by mechlorethamine and azathioprine

Journal of Surgical Oncology, 1971
AbstractPCO, a deproteinized yeast extract of low toxicity, increases tissue respiration, offsets the toxicity of mechlorethamine hydrochloride (HN2) for mice with maintenance of antineoplastic activity in the systems studied, and is a useful adjuvant to azathioprine in dog renal allografts. The two latter effects appear to be related to the ability of
E S, Cook, L G, Nutini
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Mechlorethamine

2000
Abstract Mechlorethamine (ME) is an alkylating chemotherapy agent; it exerts its primary effect on dividing cells by alkylating pyrimidine and purine bases which prevents repliction of DNA and causes cell death. ME was the first nitro gen mustard to be introduced and is the most reactive of the drugs in this class.
openaire   +1 more source

Ointment-based mechlorethamine treatment for mycosis fungoides

Cancer, 1983
The treatment of skin disease with topical mechlorethamine has been restricted because of the frequent development of contact dermatitis. A series of 43 patients with mycosis fungoides in Stages 1A (17), IB (22), II (2), and III (2) were treated with an ointment-based mechlorethamine, prepared by an anhydrous method.
N M, Price, R T, Hoppe, D G, Deneau
openaire   +2 more sources

[14C]Mechlorethamine Binding to Proteins of the Human Keratinocyte

Military Medicine, 1990
Much mustard agent research has focused on mustard/DNA interactions. Mustard also interacts with proteins, however, and to reach the DNA any agent must first pass through the cytoplasm. We hypothesized that the cell's proteins would covalently bind mustard, and thereby limit its access to the DNA.
M A, Deaton, G P, Jones, P D, Bowman
openaire   +2 more sources

Mechlorethamine-induced enhancement of radiation sensitivity of guanine

International Journal of Radiation Biology, 1996
This study describes and characterizes the interactions of nitrogen mustard mechlorethamine (HN2) with guanine and the radiation sensitivity of guanine in the presence of HN2. Briefly, in an equimolar solution (0.5 mmol dm-3) the pH-dependence (pH 3.0-12.0) and time-dependence (0-36 h) of alkylation of guanine at room temperature were determined using ...
Y N, Vaishnav, C E, Swenberg
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Mechlorethamine Hydrochloride Solutions and Ointment

Archives of Dermatology, 1980
• Solutions of mechlorethamine hydrochloride used to treat patients with mycosis fungoides and psoriasis are stable for many months, especially when they are refrigerated. This fact should make the use of this treatment more convenient. On the other hand, the risk of cancer induction from such use should be appreciated.
openaire   +1 more source

Mechlorethamine desensitization in therapy for mycosis fungoides. Topical desensitization to mechlorethamine (nitrogen mustard) contact hypersensitivity.

Archives of dermatology, 1975
Five patients with mycosis fungoides who had developed contact dermatitis to a nitrogen mustard, mechlorethamine hydrochloride, even in low concentrations (1 to 5 mg/100 ml), received daily total-body applications of extremely dilute solutions (0.01 to 0.1 mg/100 ml) of mechlorethamine.
V S, Constantine, Z Y, Fuks, E M, Farber
openaire   +1 more source