Results 141 to 150 of about 2,699 (183)
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Studies in the Pharmacodynamics of Mechlorethamine and AB 100
JAMA, 1961ALKYLATING agents have been used in the Ltreatment of neoplastic disease since 1931, when Adair and Bagg 1 described experiences with topical application of sulfur mustard. Intensive investigation during World War II resulted in a greater appreciation of the usefulness of these compounds.
R K, AUSMAN +4 more
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Ointment-based mechlorethamine treatment for mycosis fungoides
Cancer, 1983The treatment of skin disease with topical mechlorethamine has been restricted because of the frequent development of contact dermatitis. A series of 43 patients with mycosis fungoides in Stages 1A (17), IB (22), II (2), and III (2) were treated with an ointment-based mechlorethamine, prepared by an anhydrous method.
Richard Hoppe, N M Price
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Chemotherapy of lymphoma with mechlorethamine and vinblastine.
Archives of internal medicine, 1973To determine the relative efficacy of mechlorethamine hydrochloride and vinblastine sulfate, 172 patients with Hodgkin's disease, lymphosarcoma, and reticulum cell sarcoma were randomly assigned to receive one or the other of these agents. If treatment with the first compound failed, each patient was to be treated with the second.
J, Solomon +5 more
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2000
Abstract Mechlorethamine (ME) is an alkylating chemotherapy agent; it exerts its primary effect on dividing cells by alkylating pyrimidine and purine bases which prevents repliction of DNA and causes cell death. ME was the first nitro gen mustard to be introduced and is the most reactive of the drugs in this class.
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Abstract Mechlorethamine (ME) is an alkylating chemotherapy agent; it exerts its primary effect on dividing cells by alkylating pyrimidine and purine bases which prevents repliction of DNA and causes cell death. ME was the first nitro gen mustard to be introduced and is the most reactive of the drugs in this class.
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Local bullous reaction to topical mechlorethamine (mustine)
Contact Dermatitis, 1990J J, Goday +3 more
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Mechlorethamine Hydrochloride Solutions and Ointment
Archives of Dermatology, 1980• Solutions of mechlorethamine hydrochloride used to treat patients with mycosis fungoides and psoriasis are stable for many months, especially when they are refrigerated. This fact should make the use of this treatment more convenient. On the other hand, the risk of cancer induction from such use should be appreciated.
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Mechlorethamine-induced enhancement of radiation sensitivity of guanine
International Journal of Radiation Biology, 1996This study describes and characterizes the interactions of nitrogen mustard mechlorethamine (HN2) with guanine and the radiation sensitivity of guanine in the presence of HN2. Briefly, in an equimolar solution (0.5 mmol dm-3) the pH-dependence (pH 3.0-12.0) and time-dependence (0-36 h) of alkylation of guanine at room temperature were determined using ...
Y N, Vaishnav, C E, Swenberg
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[14C]Mechlorethamine Binding to Proteins of the Human Keratinocyte
Military Medicine, 1990Much mustard agent research has focused on mustard/DNA interactions. Mustard also interacts with proteins, however, and to reach the DNA any agent must first pass through the cytoplasm. We hypothesized that the cell's proteins would covalently bind mustard, and thereby limit its access to the DNA.
M A, Deaton, G P, Jones, P D, Bowman
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Bone Marrow Protection in Mechlorethamine (Nitrogen Mustard) Therapy
Archives of Surgery, 1962The hematologic effects of mechlorethamine hydrochloride (nitrogen mustard) limit the dose employed when this drug is used for chemotherapy of advanced cancer. Although other toxicities are recognized, e.g., of the intestinal and central nervous system, they represent effects at higher dosage levels than are ordinarily used.
D G, MILLER, W, LAWRENCE
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The Impact of Drug Shortages on Children with Cancer — The Example of Mechlorethamine
New England Journal of Medicine, 2012Among the generic drugs in short supply is mechlorethamine, part of a standard regimen for pediatric Hodgkin's lymphoma. The Pediatric Hodgkin Lymphoma Consortium has substituted cyclophosphamide, which is less effective and increases the risk of complications.
Monika L, Metzger +2 more
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