Results 201 to 210 of about 5,025 (229)

The Impact of Drug Shortages on Children with Cancer — The Example of Mechlorethamine

New England Journal of Medicine, 2012
Among the generic drugs in short supply is mechlorethamine, part of a standard regimen for pediatric Hodgkin's lymphoma. The Pediatric Hodgkin Lymphoma Consortium has substituted cyclophosphamide, which is less effective and increases the risk of complications.
Monika L. Metzger, Amy L. Billett, Michael P. Link   +2 more
openaire   +3 more sources

Mechlorethamine HCl and Cyclophosphamide in the Treatment of Hodgkin's Disease and the Lymphomas

JAMA: The Journal of the American Medical Association, 1968
Eighty-six patients (37 with Hodgkin's disease, 37 with lymphosarcoma, and 12 with reticulum cell sarcoma) were randomized and treated with either a single dose of mechlorethamine hydrochloride (0.4 mg/kg of body weight, given intravenously) followed by daily maintenance with chlorambucil (given orally), or a loading dose of cyclophosphamide (40 mg/kg ...
Edwin M. Jacobs, Darien Wood, Frances C. Peters, Calvin Zippin, James K. Luce   +4 more
openaire   +3 more sources

Generation and Single-Molecule Characterization of a Sequence-Selective Covalent Cross-Link Mediated by Mechlorethamine at a C-C Mismatch in Duplex DNA for Discrimination of a Disease-Relevant Single Nucleotide Polymorphism.

Bioconjugate chemistry, 2018
Many strategies for the detection of nucleic acid sequence rely upon Watson-Crick hybridization of a probe strand to the target strand, but the reversible nature of nucleic acid hybridization presents an inherent challenge: short probes that provide high
Ruicheng Shi, M. I. Nejad, Xinyue Zhang, L. Gu, K. Gates   +4 more
semanticscholar   +1 more source

Investigation of Drug Delivery of Mechlorethamine (Anticancer Drug) by Si76, C76, Al38N38 Nanocages

Silicon, 2023
Shereen M. Mekkey, F. Al-dolaimy, Uday Abdul-Reda Hussein, Shahad Mohammed Dhiaa Younis, A. J. Kadhim, Mustafa Wathiq Abdul Kareem, Noor Kadhim Abed, Mohammed Asiri, Safa Alkhayyat, A. Alsalamy   +9 more
semanticscholar   +1 more source

Mono- and Di-Alkylation Processes of DNA Bases by Nitrogen Mustard Mechlorethamine.

ChemPhysChem, 2017
The reactivity of nitrogen mustard mechlorethamine (mec) with purine bases towards formation of mono- (G-mec and A-mec) and dialkylated (AA-mec, GG-mec and AG-mec) adducts has been studied using density functional theory (DFT).
Olatz Larrañaga, A. de Cózar, F. Cossío   +2 more
semanticscholar   +1 more source

Tumorigenic effect of topical mechlorethamine, BCNU and CCNU in mice

Experientia, 1980
Mice were painted with mechlorethamine (HN2), carmustine (BCNU) and lomustine (CCNU) for up to 33 weeks. HN2 was a potent carcinogen, producing squamous cell carcinomas in 9 of 33 mice in 1 series. BCNU was a weak carcinogen. CCNU produced no tumors in 1 series.
E. A. Smuckler, H. S. Zackheim
openaire   +3 more sources

Reduction of Nitroarylmethyl Quaternary Ammonium Prodrugs of Mechlorethamine by Radiation

Radiation Research, 1998
Nitroarylmethyl quaternary ammonium nitrogen mustards are bioreductive drugs designed to release mechlorethamine, when reduced metabolically, via fragmentation of the initial nitro radical anion to a benzylic-type radical. This proposed mechanism (termed Type I) is analogous to the well-known reductive fragmentation of 2-nitrobenzyl halides.
William R. Wilson, Moana Tercel, William A. Denny, Dianne M. Ferry, Robert F. Anderson   +4 more
openaire   +3 more sources

Response to Chlormethine/Mechlorethamine gel Maintenance Treatment Regimen in Patients With Mycosis Fungoides: A Single-center Retrospective Study.

Clinical Lymphoma, Myeloma & Leukemia, 2022
E. Correia, Shalini Krishasamy, Jayson Suriano, W. Shi, S. Alpdogan, Joya Sahu, P. Porcu, N. Nikbakht   +7 more
semanticscholar   +1 more source

Photo-triggered fluorescent theranostic prodrugs as DNA alkylating agents for mechlorethamine release and spatiotemporal monitoring.

Organic and biomolecular chemistry, 2015
We describe a new theranostic strategy for selective delivery and spatiotemporal monitoring of mechlorethamine, a DNA alkylating agent. A photo-responsive prodrug is designed and composed of a photolabile o-nitrophenylethyl group, a DNA alkylating ...
Yanting Cao, Rong Pan, Weimin Xuan, Yongyi Wei, Kejian Liu, Jiahong Zhou, Wei Wang   +6 more
semanticscholar   +1 more source

Mechlorethamine, vincristine, melphalan and prednisone (MOMP) for the treatment of relapsed lymphoma in dogs.

Veterinary and Comparative Oncology, 2015
Eighty-eight dogs with relapsed lymphoma were treated with the MOMP (mechlorethamine, vincristine, melphalan and prednisone) protocol on a 28-day treatment cycle.
A. Back, S. Schleis, O. Smrkovski, J. Lee, Annette N. Smith, J. Phillips   +5 more
semanticscholar   +1 more source