Results 211 to 220 of about 4,334,118 (337)

Auxin affects gene editing efficiency through regulating chromatin accessibility and plant regeneration process. [PDF]

Hortic Res
Lian Z, Jiang T, Liang Y, Hu W, Peng H, Zhang H, Gong H, You C, Wang G, Liu L, Huo H.   +10 more
europepmc   +1 more source

Diabetes‐induced vascular calcification is associated with low pyrophosphate and its oral supplementation prevents calcification in diabetic mice

FEBS Open Bio, EarlyView.
Induction of diabetes in three different mouse strains uniformly resulted in an increase in TNAP activity and a reduction in pyrophosphate (PPi) in the circulation. Inhibition of TNAP restored plasma PPi. Diabetes‐induced calcification in the media layer of the aorta was detected only in the Abcc6−/− strain, which is predisposed to ectopic ...
Krisztina Fülöp, Eszter Kozák, Natália Tőkési, Lilian Kocsis, Anikó Kelemen, Zsuzsanna Geszti, Adriána Kutás, Mariann Harangi, Ágnes Diószegi, Zsolt Rapi, József Balla, Olivier Le Saux, András Váradi, Viola Pomozi   +13 more
wiley   +1 more source

Development and early reach of a podcast-based innovation to support medical residents' personal and professional development. [PDF]

Med Educ Online
Smit MP, van Loon KA, Gemke RJBJ, de Hoog M, van der Velden J.   +4 more
europepmc   +1 more source

Representation in Media Accessibility

This article is a theoretical essay discussing the potential for the analysis of media accessibility contents and practices (AD, SDH, Sign Language Interpreting, etc.) through a queer feminist lens, which makes it possible to tackle the representation of diversity and non-normativity. Based on a literature review of previous workson the intersection of
openaire   +1 more source

Calcium‐sensing receptor induces the apoptosis of chondrocytes in cooperation with phosphate transporter

FEBS Open Bio, EarlyView.
Excess Ca2+ ions activate the Calcium‐Sensing Receptor (CaSR), which subsequently drives the uptake of excess inorganic phosphate (Pi) via the Pi transporter (Pit−1) in chondrocytes. This mechanism causes a toxic increase in intracellular Pi concentration, ultimately leading to chondrocyte apoptosis and pathological mineralization. Excess extracellular
Sachie Nakatani, Hiroya Ueda, Ayumi Kawata, Yuki Sato, Kotomi Inomata, Hiroshi Mano, Masahiro Wada, Kenji Kobata   +7 more
wiley   +1 more source

Factors Influencing Patients' Choice of a Joint Replacement Surgeon. [PDF]

Cureus
Grayson W, Basich G, Schmitt D, Brown N.
europepmc   +1 more source

Impact of a senior research thesis on students' perceptions of scientific inquiry in distinct student populations

FEBS Open Bio, EarlyView.
This study addressed how a senior research thesis is perceived by undergraduate students. It assessed students' perception of research skills, epistemological beliefs, and career goals in Biochemistry (science) and BDC (science‐business) students. Completing a thesis improved confidence in research skills, resilience, scientific identity, closed gender‐
Celeste Suart, Haley L. Zubyk, Michelle Ogrodnik, Caitlin E. Mullarkey, Felicia Vulcu   +4 more
wiley   +1 more source

Hepatic adaptation to chronic metabolic stress primes tumorigenesis. [PDF]

Cell
Tzouanas CN, Shay JES, Sherman MS, Rubin AJ, Mead BE, Dao TT, Tao J, Lehrich BM, Eng G, Patterson-Fortin J, Butzlaff T, Mana MD, Kolb KE, Walesky C, Pepe-Mooney BJ, Smith CJ, Prakadan SM, Ramseier ML, Tong YE, Joung J, Chi F, McMahon-Skates T, Winston CL, Jeong WJ, Aney KJ, Chen E, Nissim S, Zhang F, Deshpande V, Monga SP, Lauer GM, Goessling W, Yilmaz ÖH, Shalek AK.   +33 more
europepmc   +1 more source

The photoswitchable cannabinoid azo‐HU308 enables optical control of Ca2+ dynamics in INS‐1 β‐cells via off‐target effects on TRPC channels

FEBS Open Bio, EarlyView.
Light activation of the photoswitchable cannabinoid ligand azo‐HU308 triggers Ca2+ influx in pancreatic β‐cells through TRPC channels, independent of CB2 cannabinoid receptors. This reveals a non‐GPCR pathway for cannabinoid modulation of β‐cell Ca2+ dynamics and establishes azo‐HU308 as an optical tool to study cannabinoid signaling through TRP ...
Alexander E. G. Viray, James A. Frank
wiley   +1 more source