Results 51 to 60 of about 1,466,926 (302)

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Social listening and crowdsourcing in disaster communication—A citizen-centered media and communication consumption perspective

Frontiers in Communication
To secure more resilient communities in the future, it is essential to strengthen the links between all actors. Communication and active engagement are tools to do so.
Nina Blom Andersen, Louise Hill, Nina Baron, Anne Bach Nielsen   +3 more
doaj   +1 more source

Partisanship, Ideology, and Selective Exposure: A Longitudinal Analysis of Media Consumption in Spain (2008–2019)

Media and Communication, 2023
The literature on selective exposure has shown that ideology and voting govern media consumption decisions, but longitudinal studies are still scarce.
María Luisa Humanes, Lidia Valera-Ordaz
doaj   +1 more source

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

General Consumer Awareness of Warnings Regarding the Consumption of Alcoholic Beverages [PDF]

, 2010
Over the past two decades, the liquor industry in Japan has strived to address alcohol-related problems through initiatives such as warnings in the various media.
Hoshino, Hiromi, Kaneita, Yoshitaka, Kokaze, Akatsuki, Ochiai, Hirotaka, Ohtsu, Tadahiro, Shimada, Naoki, Shirasawa, Takako, Takaishi, Masahiro   +7 more
core   +1 more source

Who Are the Young Adults in Portugal? Daily Usage of Social Media and Mobile Phones, in a No-Kids and No-Independent Housing Context—Results from a Representative Online Survey

Youth, 2023
Better theories and practices are constructed through a deep understanding of the subjects involved. In Portugal, young adults aged 18 to 30 are a group sometimes left out because the Portuguese official statistical data does not treat this as an age ...
Eduardo Antunes, Inês Amaral, Rita Basílio Simões, Ana Marta M. Flores   +3 more
doaj   +1 more source

LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro

Molecular Oncology, EarlyView.
Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix, Daniel Samaga, Katharina Gehr, Benedek Dankó, Mohamed Schumann, Guido Drexler, Ahmed Alnatsha, Georg Beyer, Ujjwal Mahajan, Martin Selmansberger, Julia Mayerle, Claus Belka, Horst Zitzelsberger, Kirsten Lauber   +13 more
wiley   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

The genome incorporated: constructing biodigital identity [PDF]

, 2010
The Genome Incorporated examines the proliferation of human genomics across contemporary media cultures. It explores questions about what it means for a technoscience to thoroughly saturate everyday life, and places the interrogation of the science/media
O'Riordan, Kate
core   +1 more source

Higher media multi-tasking activity is associated with smaller gray-matter density in the anterior cingulate cortex [PDF]

, 2014
Media multitasking, or the concurrent consumption of multiple media forms, is increasingly prevalent in today’s society and has been associated with negative psychosocial and cognitive impacts.
B Draganski, BC Ralph, BJ Casey, C Blakemore, CG DeYoung, CS Carter, D Swick, D Swick, DM Sanbonmatsu, E Koechlin, E Ophir, EK Miller, F Lin, G Bush, G Bush, H Yamasue, HC Leung, J Ashburner, J Ashburner, J Boyke, JC Dreher, JY Rotge, K Yuan, KA Kiehl, Katsumi Watanabe, Kep Kee Loh, KF Lui, KI Erickson, LK Fellows, M Botvinick, M Corbetta, ME Raichle, MM Botvinick, MP Milham, MW Becker, O Devinsky, PE Dux, PW Burgess, R Alzahabi, R Junco, R Kanai, R Marois, R Pea, RL Buckner, Ryota Kanai, S Whitfield-Gabrieli, SC Caetano, TR Franklin, Y Zhou   +48 more
core   +2 more sources