Results 71 to 80 of about 932,965 (310)

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

Social construction of drug policies and target populations: U.S. Policy and media discourse

open access: yesActa Universitatis Lodziensis: Folia Sociologica, 2017
In this review, we discuss the historical changes in U.S. drug policy discourse, institutional racism, and the social construction of target populations in media discourse.
Jonathan Langner, Anna Zajicek
doaj   +1 more source

Constructions of welfare recipients and work in New Zealand newspapers : an examination of discourse and policy : a thesis presented in fulfilment of the requirements for the degree of Master of Arts in Psychology at Massey University, New Zealand [PDF]

open access: yes, 2016
This paper drew from discursive psychology and Foucauldian discourse analysis to analyse and critique constructions of welfare, its recipients and proposed policies as they were discussed in 200 New Zealand newspaper accounts published between 2005 and ...
Wilson, Kimberly Rose
core  

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

open access: yesFEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson   +7 more
wiley   +1 more source

Rationalization in Media Discourse

open access: yesInternational Journal of Social Science and Human Research, 2022
We will analyze how women subject to violence in Morocco legitimize their discourse through the use of one legitimation techniques called rationalization, the aim of which is to establish a mode of argumentation that victimizes them and demonizes the violent husbands.
openaire   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Arab Media Discourse: Breaking Taboos

open access: yesKervan. International Journal of Afro-Asiatic Studies, 2016
This paper examines the development and change of Arab media discourse since mid-1990s. The paper looks at how the production and consumption of media discourse have changed dramatically in the Arab world over the last decade or so, notably in relation ...
El Mustapha Lahlali
doaj   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

open access: yesFEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai   +9 more
wiley   +1 more source

The Democratization of Social Media A Critical Perspective in Technology [PDF]

open access: yes, 2017
Social Media is part of contemporary technology that is the contentious subject matter within the society. It is paradoxical when social media should provide techniques and objects that serve human being in a positive way, but at the same time, it can ...
Mahaswa, Rangga Kala
core  

Tau acetylation at K331 has limited impact on tau pathology in vivo

open access: yesFEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto   +3 more
wiley   +1 more source

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