Results 41 to 50 of about 18,685,210 (287)

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

open access: yesMolecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan   +16 more
wiley   +1 more source

Different strokes for different folk: Regulatory distinctions in New Zealand media

open access: yesPacific Journalism Review, 2005
For much of the past century there was broad acceptance of the stark contrast between the state’s involvement in the regulation of the content of broadcasting and its laissez-faire relationship with the columns of the press.
Gavin Ellis
doaj   +1 more source

Ethics of Media

open access: yesInternational Journal For Multidisciplinary Research, 2023
Very often, the media is labeled as the fourth pillar of democracy along with the legislature, the executive and the judiciary. The population generally banks on the media to be unbiased, accurate and fair and report the whole truth without having an agenda of its own.
openaire   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

open access: yesMolecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska   +13 more
wiley   +1 more source

Advisory board : engineering ethics case study project [PDF]

open access: yes, 2010
This is an Engineering Ethics case study from the IDEA CETL. It examines how membership of an advisory committee might lead to a conflict of interest. It considers integrity and public duty.
Inter-Disciplinary Ethics Applied Cetl, University of Leeds
core  

Six Oceania microstates: The genesis of media accountability

open access: yesPacific Journalism Review, 2005
Media accountability systems (M*A*S) have been slow to take root in Oceania. Apart from Papua New Guinea, Fiji is the trend-setter in the region. Following the establishment of the Fiji Media Council in the mid-1990s, several other South Pacific island ...
Shailendra Singh
doaj   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

open access: yesMolecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober   +16 more
wiley   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

open access: yesMolecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka   +9 more
wiley   +1 more source

ප්‍රේමයෙන් මුසපත් වී බෑගයෙන් සහ කඹයෙන් අවසන් ගමනේ

open access: yes, 2021
On March 07 Divaina reported on suicide and Murder in a manner that did not comply with media ethics ...
Ethics Eye
core   +1 more source

දිවි තොරකර ගැනීම් සහ දෝෂාරෝපණයන්: ආචාර ධාර්මික මාධ්‍යකරණයද?

open access: yes, 2021
On March 01,2021 Sunday Observer reported on suicide in a manner that did not comply with media ethics ...
Ethics Eye
core   +1 more source

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