Results 61 to 70 of about 18,685,210 (287)

NAPRT loss promotes lung tumor initiation and growth through AKT signaling independently of NAD+ biosynthesis

open access: yesMolecular Oncology, EarlyView.
Loss of NAPRT promotes lung tumor initiation and growth through a noncanonical mechanism, independent of its role in NAD+ biosynthesis. Mechanistically, NAPRT depletion activates the mTORC2‐driven AKT/β‐catenin signaling axis to enhance clonogenic and invasive phenotypes. Furthermore, lung‐specific Naprt deletion significantly increases tumor burden in
Myung Joon Oh   +11 more
wiley   +1 more source

Legal and Ethical Regulation in Slovakia and Its Relation to Deliberative Communication

open access: yesMedia and Communication
The offered social-scientific analysis is based on a critical discussion of key problems present in the Slovak media environment, such as the ethical self-regulation of the media, freedom of expression, the right to obtain information, or the legal ...
Ľudmila Čábyová   +5 more
doaj   +1 more source

p190A/ARHGAP35 and p190B/ARHGAP5 proteins in endometrial cancer: a novel cancer‐relevant paralog interplay

open access: yesMolecular Oncology, EarlyView.
This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault   +12 more
wiley   +1 more source

Global Media Ethics Problems and Perspectives

open access: yes, 2013
Global Media Ethics is the first comprehensive cross-cultural exploration of the conceptual and practical issues facing media ethics in a global world.
Ward, Stephen J. A.
core  

Bridging the gap: a genetically validated avian chorioallantoic membrane platform for investigation of spontaneous circulating tumor cells

open access: yesMolecular Oncology, EarlyView.
We established the avian chorioallantoic membrane (CAM) assay as a scalable in vivo model for studying circulating tumor cells (CTCs). Human gastrointestinal tumors spontaneously released genetically validated CTCs that were detected across multiple platforms, demonstrating that the CAM model provides an accessible tool for investigating early cancer ...
Dennis Roth   +17 more
wiley   +1 more source

War Propaganda and Correspondents: Updating UN Covenant and Media Ethics Principles [PDF]

open access: yesAthens Journal of Mass Media and Communications
This study is an examination of war propaganda and correspondents in concomitance with the 1948 Resolution 217A of the UN Covenant prohibiting war propaganda under the rubric of media ethics and the applicable principles and guidelines.
Festus Eribo
doaj   +1 more source

Extracellular matrix remodeling and immune reprogramming drive residual tumor progression of liver cancer after incomplete microwave ablation

open access: yesMolecular Oncology, EarlyView.
Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu   +9 more
wiley   +1 more source

ETIKA MEDIA DALAM PILKADA : SIARAN “KAMPANYE” DI TELEVISI LOKAL

open access: yesJurnal Ilmu Sosial, 2016
The aim of this research was to describe the understanding and ethical considerations of media professionals in the coverage of Central Java governor election.
Triyono Lukmantoro   +2 more
doaj  

The latest casualty: Phillip Knightley and media failure

open access: yesPacific Journalism Review, 2003
He covers the coverage of wars and the fine borderline that journalists might cross to become propaganda merchants: World War II, Vietnam, The Gulf, Kosovo, to name a few, and now the ‘War on Terror’.
Louise Matthews
doaj   +1 more source

Reprogramming tumor cells with LCOR mRNA nanotherapy to enhance immunotherapy

open access: yesMolecular Oncology, EarlyView.
LCOR (Ligand‐dependent corepressor) mRNA encapsulated in polymeric nanoparticles restores LCOR activity in tumor cells, constraining aggressive tumor cell states and increasing tumor immunogenicity. This reprogramming makes tumor cells more vulnerable to T‐cell attack and enhances their response to immune‐checkpoint immunotherapy.
Gabriel Serra‐Mir   +9 more
wiley   +1 more source

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