Results 101 to 110 of about 66,044 (308)
Knight News Challenge: Casting the Net Wide for Innovation [PDF]
, 2010 Reviews the evolution of the Knight News Challenge contest for experimental projects in digital delivery of news and information to local communities, profiles winning projects and explores the grants' impact, and considers issues of ...
Christopher Connell
core
A Writer, an Editor, an Instructor, and an Alumna Walk into the Writing Center [PDF]
, 2009 As the writing center director, I believe our professional tutors provide valuable expert perspectives to student writers. They also help me mentor the peer tutors and push me to reevaluate our practices.
Campbell, Lindsey +4 more
core +1 more source
Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids
Molecular Oncology, EarlyView.This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici +8 more
wiley +1 more source
Fansubbing del español al chino : organización, roles y normas en la escritura colaborativa
BiD: Textos Universitaris de Biblioteconomia i Documentació, 2016 Objetivo: documentar y analizar la cooperación en línea de una comunidad digital que subtitula series y películas hispanas al chino, estudiando los roles y las funciones, la cadena de trabajo, los espacios virtuales, las estrategias de autorregulación y ...
Zhang, Tian Leticia, Cassany, Daniel
doaj +1 more source
Molecular Oncology, EarlyView.Following high dose rate brachytherapy (HDR‐BT) for hepatocellular carcinoma (HCC), patients were classified as responders and nonresponders. Post‐therapy serum induced increased BrdU incorporation and Cyclin E expression of Huh7 and HepG2 cells in nonresponders, but decreased levels in responders.
Lukas Salvermoser +14 more
wiley +1 more source
Inhibition of CDK9 enhances AML cell death induced by combined venetoclax and azacitidine
Molecular Oncology, EarlyView.The CDK9 inhibitor AZD4573 downregulates c‐MYC and MCL‐1 to induce death of cytarabine (AraC)‐resistant AML cells. This enhances VEN + AZA‐induced cell death significantly more than any combination of two of the three drugs in AraC‐resistant AML cells.
Shuangshuang Wu +18 more
wiley +1 more source
Design Your Career - Design Your Life [PDF]
, 2019 This research investigates the current plague of unemployment and underemployment that nearly half of qualified individuals in the field of Visual Communications are met with after graduation. Students who major in this field dedicate a tremendous amount
Beal, Joshua R
core +1 more source
A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression
Molecular Oncology, EarlyView.Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak +8 more
wiley +1 more source
The State of the U.S. Workforce System: A Time for Incremental Realignment or Serious Reform? [PDF]
, 2012 A report from the John J. Heldrich Center for Workforce Development aims to start a dialogue about the U.S. workforce system, and what it would look like if it were built for today's economy and by using today's tools and processes.
Kathy Krepcio, Michele Martin
core
Molecular Oncology, EarlyView.Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié +16 more
wiley +1 more source