Results 111 to 120 of about 50,853,159 (386)

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

open access: yesFEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson   +7 more
wiley   +1 more source

Social Media Usage: A Comparison of Public Relations/Journalism and Marketing/Management Students [PDF]

open access: yes, 2013
Research indicates that students use social media for more social reasons than professional reasons. To test the assumptions in the literature, this study examined key disciplines having a professional connection to undergraduate studies.
Baker, Jabril   +2 more
core   +2 more sources

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

open access: yesMolecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero   +8 more
wiley   +1 more source

Digital Materialisms: Frameworks for Digital Media Studies

open access: yes, 2015
Since the 1980s, digital materialism has received increasing interest in the field of media studies. Materialism as a theoretical paradigm assumes that all things in the world are tied to physical processes and matter.
Nathalie Casemajor
semanticscholar   +1 more source

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

open access: yesMolecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou   +5 more
wiley   +1 more source

Diversity in Western Countries: Journalism Culture, Migration Integration Policy and Public Opinion

open access: yesMedia and Communication, 2019
Earlier research has shown that public opinion and policy lines on the topic of immigrant integration are interrelated. This article investigates a sample of 24 countries for which data are available in the Migrant Integration Policy Index (MIPEX), the ...
Stefan Mertens   +3 more
doaj   +1 more source

Studies of new media radiation induced laser [PDF]

open access: yes
Various lasants were investigated especially, 2-iodohepafluoropropane (i-C3F7I) for the direct solar pumped lasers. Optical pumping of iodine laser was achieved using a small flashlamp.
Han, K. S.   +4 more
core   +1 more source

Social Media and it\u27s Effects on Mental Health of High School Students [PDF]

open access: yes, 2020
Previous studies have established a link between mental health and social media usage. That research has shown that social media usage in students can be detrimental to their self-esteem, motivation, and generalized anxiety.
Brandy, Emma   +2 more
core   +1 more source

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