Results 121 to 130 of about 31,242,454 (306)
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Molecular Oncology, EarlyView.In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera +11 more
wiley +1 more source
Ingredients for a User Interface to Support Media Studies Researchers in Data Collection [PDF]
, 2012 We describe our efforts to design an interface that supports media studies researchers in collecting data. Based on interviews about their search behavior we arrive at a set of search scenarios and for each we identify IR techniques that provide the ...
de Rijke, M. +6 more
core +1 more source
KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer
Molecular Oncology, EarlyView.Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan +16 more
wiley +1 more source
PLENARY SESSION IV. Rhetorics in Media Studies – Media Studies in Rhetorics. Rhetoric in Media Studies [PDF]
Nordicom Review, 2004 openaire +3 more sources
ENGLISH- STEREOTYPING OF ISLAM AND MUSLIMS IN HOLLYWOOD MOVIES: AN ANALYSIS OF REPRESENTATION
دی اسکالر, 2020 Hollywood movies are very popular in most nations around the world and the viewers of these countries turn to Hollywood blockbusters for entertainment purposes.
Muhammad Yousaf +3 more
doaj
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Discover EducationThe complex interplay linking educational interventions with personality development in fostering green entrepreneurial intention (GEI) remains insufficiently explored within African higher education contexts.
Emefa Akua Amponsah +4 more
doaj +1 more source
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source