Results 111 to 120 of about 6,828,197 (312)
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
Could social media improve New Save Supermarket’s Asian market segment? [PDF]
, 2018 Social media has become a part of people’s daily life. It is a multi-functional tool for people, who use social media to communicate with others, share content, and consume information in real time.
Deng, Siting, Yeung, Deniss
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Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma
Molecular Oncology, EarlyView.Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken +7 more
wiley +1 more source
The Effects of Social Media Use on the Perceptions of Mental Illness Among College Students [PDF]
, 2019 This study examined individuals’ use of and perceptions of social media networking sites (i.e. Facebook and Twitter) on their perceptions of mental illness.
Fisher, Brea
core +1 more source
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Frontiers in PsychologyObjectivesThis study investigated associations between the use of electronic media and sleep in children and young adolescents, with a specific focus on the moderation of associations by sex and age.MethodsBetween 2021 and 2022, 453 10- to 14-year-old ...
Tanja Poulain +6 more
doaj +1 more source
The Use of Mother Tongue in General English Program for Teenagers in the Second and Fourth Levels [PDF]
, 2014 This study reports the teacher's use of mother tongue (Bahasa Indonesia) in English as Foreign Language (EFL) classroom in Indonesia. The study was conducted in an English language course for teenagers, and focused more in the second and fourth level ...
Bawono, K. O. (Katherine) +1 more
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LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro
Molecular Oncology, EarlyView.Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix +13 more
wiley +1 more source
European Journal of PsychotraumatologyIntroduction: On 13–14 April 2024, Iran launched ∼300 drones and missiles at Israel, in an unprecedented attack. As most studies examine the effects of trauma months or years later, less is known about its effects days later. To fill this gap, this study
Boaz M. Ben-David +4 more
doaj +1 more source
The Use of Ellipsis by Character ‘Hazel' in “the Fault in Our Stars” Movie Script [PDF]
, 2015 Ellipsis is omission of words which has been understood well from the omissionwill not change the meaning of the utterance itself. We can find mostly ellipsis inspoken language.
Silitonga, M. S. (Martha)
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