Results 131 to 140 of about 6,893,201 (314)
The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity
Molecular Oncology, EarlyView.Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli +7 more
wiley +1 more source
Political Marketing: How Social Media influenced the 2008-2016 U.S. Presidential Elections and Best Practices Associated [PDF]
, 2018 Political marketing has become a growing facet of marketing that has infiltrated the campaigning of U.S. presidential elections. Within this cognate of marketing, social media has become a major component of predicting election outcomes starting with the
Swartley, Morgan
core +1 more source
Molecular Oncology, EarlyView.Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley +5 more
wiley +1 more source
Molecular Oncology, EarlyView.This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns +10 more
wiley +1 more source
Understanding the role of social media in political corporate branding research in the context of Indian politics [PDF]
, 2015 This paper seeks to explore how political actors within the Bharatiya Janata Party (BJP) use social media in their communication campaigns and how these social media platforms are understood by citizens following the 2014 Indian General Election.
Armannsdottir, G +3 more
core
Molecular Oncology, EarlyView.Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova +25 more
wiley +1 more source
From a Global Perspective, Based on Cost‐Benefit Analysis, Which Social Media Tool(s) is/are the Most Effective for Attracting Talent? [PDF]
, 2014 Social media usage has been growing quite impressively in the last few years, and it has penetrated the recruiting market almost entirely: the number of companies using social media to support their recruitment efforts has gone from 78% in 2008 to 92% in
Ameisen, Emmanuel, Balter, Roscoe
core +1 more source
Transitions in social media use and social media use for transition
Proceedings of the International Conference on Networked LearningHigh school and college students are known to be heavy users of social media. Much of their use is focused on peer social interactions and entertainment, but social media is also a potential platform for informal networked learning. In this study, we examine how college students used social media to learn about and prepare for college, how they use it ...
Vanessa P. Dennen, Lauren M. Bagdy
openaire +1 more source
Molecular Oncology, EarlyView.Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano +6 more
wiley +1 more source