Results 121 to 130 of about 30,993,265 (250)
UK demand for hyperlocal media [PDF]
, 2013 In March 2012, Nesta published Here and now, the first landscape review of hyperlocal media in the UK. Since then, they have continued our programme of practical experimentation and research, called Destination Local, to develop a strong ...
core
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
Consumer awareness and the use of payment media: evidence from young Finnish consumers [PDF]
In the market for payment media, some consumers use only one medium when paying for their point-of-sale transactions, while others use many. This pattern reflects the diffusion of new payment media, because a payment method innovation is typically first ...
Hyytinen, Ari, Takalo, Tuomas
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Frequent Media Use, Media Multitasking, and Perceived Cost of Cognitive Effort
People regard cognitive effort as costly and try to conserve such effort whenever possible. This study aimed to examine the relationship between frequent media use and perceived cost for cognitive effort.
Murphy, Karen, Shin, Myoungju
core +1 more source
The use of the internet in media education [PDF]
, 2010 The Internet has become the main information and data provider since its appearance at the end of the 20th century. Currently, all over the world, universities, as the main generators and consumers of information, stand at the top of the privileged organizations that have access to the Internet.
Özad, Bahire Efe, Kutoğlu, Ülfet
openaire +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
Health minister asks media outlets not to use Drinkaware information.
, 2019 Drinkaware is funded by the drinks industry and Harris asked media organisations to use HSE ...
Mcgrath, Dominic
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Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer
Molecular Oncology, EarlyView.Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola +11 more
wiley +1 more source