Results 41 to 50 of about 24,307 (213)

Spatial and memory circuits in the medial entorhinal cortex

Current Opinion in Neurobiology, 2015
The large capacity of episodic memory is thought to be supported by the emergence of distinct hippocampal cell assemblies for unrelated memories, such that interference is minimized. In large-scale population recordings, the orthogonal nature of hippocampal representations across environments is evident in the complete reorganization of the firing ...
Sasaki, Takuya, Leutgeb, Stefan, Leutgeb, Jill K   +2 more
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Convergent Projections from Perirhinal and Postrhinal Cortices Suggest a Multisensory Nature of Lateral, but Not Medial, Entorhinal Cortex

Cell Reports, 2019
Summary: The current model of the organization of the medial temporal lobe (MTL) episodic memory system assumes that two functionally different “where” and “what” pathways enter MTL as parallel parahippocampal cortex (PHC)-medial entorhinal cortex (MEC ...
Thanh P. Doan, Maria J. Lagartos-Donate, Eirik S. Nilssen, Shinya Ohara, Menno P. Witter   +4 more
doaj   +1 more source

Production of human entorhinal stellate cell-like cells by forward programming shows an important role of Foxp1 in reprogramming

Frontiers in Cell and Developmental Biology, 2022
Stellate cells are principal neurons in the entorhinal cortex that contribute to spatial processing. They also play a role in the context of Alzheimer’s disease as they accumulate Amyloid beta early in the disease.
Tobias Bergmann, Yong Liu, Jonathan Skov, Leo Mogus, Julie Lee, Julie Lee, Ulrich Pfisterer, Louis-Francois Handfield, Andrea Asenjo-Martinez, Irene Lisa-Vargas, Stefan E. Seemann, Jimmy Tsz Hang Lee, Nikolaos Patikas, Birgitte Rahbek Kornum, Mark Denham, Poul Hyttel, Menno P. Witter, Jan Gorodkin, Tune H. Pers, Martin Hemberg, Konstantin Khodosevich, Vanessa Jane Hall   +21 more
doaj   +1 more source

Optimal Population Codes for Space: Grid Cells Outperform Place Cells [PDF]

, 2012
Rodents use two distinct neuronal coordinate systems to estimate their position: place fields in the hippocampus and grid fields in the entorhinal cortex.
Stemmler, Martin B., Stemmler, Martin, Herz, Andreas V. M., Mathis, Alexander   +3 more
core   +1 more source

Evidence for allocentric boundary and goal direction information in the human entorhinal cortex and subiculum

Nature Communications, 2019
In rodents, cells in the medial entorhinal cortex and subiculum are known to encode the allocentric direction to nearby walls and boundaries. Here, using fMRI the authors show that this is also true in humans, with allocentric boundary direction being ...
J. P. Shine, J. P. Valdés-Herrera, C. Tempelmann, T. Wolbers   +3 more
doaj   +1 more source

Cortical thickness atrophy in the transentorhinal cortex in mild cognitive impairment

NeuroImage: Clinical, 2019
This study examines the atrophy rates of subjects with mild cognitive impairment (MCI) compared to controls in four regions within the medial temporal lobe: the transentorhinal cortex (TEC), entorhinal cortex (ERC), hippocampus, and amygdala.
Sue Kulason, Daniel J. Tward, Timothy Brown, Chelsea S. Sicat, Chin-Fu Liu, J. Tilak Ratnanather, Laurent Younes, Arnold Bakker, Michela Gallagher, Marilyn Albert, Michael I. Miller   +10 more
doaj   +1 more source

Structural modularity and grid activity in the medial entorhinal cortex [PDF]

Journal of Neurophysiology, 2018
Following the groundbreaking discovery of grid cells, the medial entorhinal cortex (MEC) has become the focus of intense anatomical, physiological, and computational investigations. Whether and how grid activity maps onto cell types and cortical architecture is still an open question.
Naumann, Robert K, Preston-Ferrer, Patricia, Brecht, Michael, Burgalossi, Andrea   +3 more
openaire   +3 more sources

Network Neurodegeneration in Alzheimer’s Disease via MRI based Shape Diffeomorphometry and High Field Atlasing

Frontiers in Bioengineering and Biotechnology, 2015
This paper examines MRI analysis of neurodegeneration in Alzheimer’s Disease (AD) in a network of structures within the medial temporal lobe using diffeomorphometry methods coupled with high-field atlasing in which the entorhinal cortex is partitioned ...
Michael I Miller, Michael I Miller, Michael I Miller, J Tilak eRatnanather, J Tilak eRatnanather, J Tilak eRatnanather, Daniel J. Tward, Daniel J. Tward, Daniel J. Tward, Timothy eBrown, David S Lee, David S Lee, Michael eKetcha, Michael eKetcha, Kanami eMori, Mei-Chang eWang, Susumu eMori, Marilyn S Albert, Laurent eYounes, Laurent eYounes, Laurent eYounes   +20 more
doaj   +1 more source

Somatostatin expressing GABAergic interneurons in the medial entorhinal cortex preferentially inhibit layerIII-V pyramidal cells

Communications Biology, 2020
Miklós Kecskés et al. show that somatostatin-expressing interneurons in the medial entorhinal cortex regulate deep-layer pyramidal neurons and impact short-term memory in mice.
Miklós Kecskés, Nóra Henn-Mike, Ágnes Agócs-Laboda, Szilárd Szőcs, Zoltán Petykó, Csaba Varga   +5 more
doaj   +1 more source

Stability of medial entorhinal cortex representations over time [PDF]

Hippocampus, 2018
AbstractDistinct functional cell types in the medial entorhinal cortex (mEC) have been shown to represent different aspects of experiences. To further characterize mEC cell populations, we examined whether spatial representations of neurons in mEC superficial layers depended on the scale of the environment and changed over extended time periods ...
Geoffrey W. Diehl, Olivia J. Hon, Stefan Leutgeb, Jill K. Leutgeb   +3 more
openaire   +2 more sources