Results 41 to 50 of about 22,462 (202)

Re-expression of CA1 and entorhinal activity patterns preserves temporal context memory at long timescales

Nature Communications, 2023
Converging, cross-species evidence indicates that memory for time is supported by hippocampal area CA1 and entorhinal cortex. However, limited evidence characterizes how these regions preserve temporal memories over long timescales (e.g., months).
Futing Zou, Guo Wanjia, Emily J. Allen, Yihan Wu, Ian Charest, Thomas Naselaris, Kendrick Kay, Brice A. Kuhl, J. Benjamin Hutchinson, Sarah DuBrow   +9 more
doaj   +1 more source

Relative contributions of CA3 and medial entorhinal cortex to memory in rats [PDF]

Frontiers in Behavioral Neuroscience, 2014
The hippocampal CA1 field processes spatial information, but the relative importance of intra- vs. extra-hippocampal sources of input into CA1 for spatial behavior is unclear. To characterize the relative roles of these two sources of input, originating in the hippocampal field CA3 and in the medial entorhinal cortex (MEC), we studied effects of ...
O'Reilly, Kally C., Alarcon, Juan M., Ferbinteanu, Janina   +2 more
openaire   +3 more sources

ARM-Cortex M3-Based Two-Wheel Robot for Assessing Grid Cell Model of Medial Entorhinal Cortex: Progress towards Building Robots with Biologically Inspired Navigation-Cognitive Maps

Journal of Robotics, 2017
This article presents the implementation and use of a two-wheel autonomous robot and its effectiveness as a tool for studying the recently discovered use of grid cells as part of mammalian’s brains space-mapping circuitry (specifically the medial ...
J. Cuneo, L. Barboni, N. Blanco, M. del Castillo, J. Quagliotti   +4 more
doaj   +1 more source

Cellular mechanisms of spatial navigation in the medial entorhinal cortex

Nature Neuroscience, 2013
Neurons in the medial entorhinal cortex exhibit a grid-like spatial pattern of spike rates that has been proposed to represent a neural code for path integration. To understand how grid cell firing arises from the combination of intrinsic conductances and synaptic input in medial entorhinal stellate cells, we performed patch-clamp recordings in mice ...
Schmidt-Hieber C, Häusser M
openaire   +2 more sources

Field repetition and local mapping in the hippocampus and the medial entorhinal cortex [PDF]

Journal of Neurophysiology, 2017
Hippocampal place cells support spatial cognition and are thought to form the neural substrate of a global “cognitive map.” A widely held view is that parts of the hippocampus also underlie the ability to separate patterns or to provide different neural codes for distinct environments.
Grieves, Roddy, Duvelle, Eleonore, Wood, Emma R, Dudchenko, Paul   +3 more
openaire   +6 more sources

Mouse entorhinal cortex encodes a diverse repertoire of self-motion signals

Nature Communications, 2021
Here, the authors show that mouse medial entorhinal cortex encodes three-dimensional head movement as well as eye position and velocity. These self-motion signals are represented conjunctively in individual neurons alongside body position, running speed,
Caitlin S. Mallory, Kiah Hardcastle, Malcolm G. Campbell, Alexander Attinger, Isabel I. C. Low, Jennifer L. Raymond, Lisa M. Giocomo   +6 more
doaj   +1 more source

Excitatory Microcircuits within Superficial Layers of the Medial Entorhinal Cortex [PDF]

Cell Reports, 2017
The distinctive firing pattern of grid cells in the medial entorhinal cortex (MEC) supports its role in the representation of space. It is widely believed that the hexagonal firing field of grid cells emerges from neural dynamics that depend on the local microcircuitry.
Winterer, Jochen, Maier, Nikolaus, Wozny, Christian, Beed, Prateep, Breustedt, Jörg, Evangelista, Roberta, Peng, Yangfan, D'Albis, Tiziano, Kempter, Richard, Schmitz, Dietmar   +9 more
openaire   +7 more sources

Shared rhythmic subcortical GABAergic input to the entorhinal cortex and presubiculum

eLife, 2018
Rhythmic theta frequency (~5–12 Hz) oscillations coordinate neuronal synchrony and higher frequency oscillations across the cortex. Spatial navigation and context-dependent episodic memories are represented in several interconnected regions including the
Tim James Viney, Minas Salib, Abhilasha Joshi, Gunes Unal, Naomi Berry, Peter Somogyi   +5 more
doaj   +1 more source

Targeting the KCNC3‐Dependent Anterior Insular‐Lateral Orbitofrontal Cortex Glutamatergic Circuit Attenuates Post‐Traumatic Anxiety

Advanced Science, EarlyView.
Frontal lobe traumatic brain injury is associated with hyperactivity of an insular–orbitofrontal circuit in both patients and mice. By combination of integrating functional imaging, cell‐type–specific circuit manipulation, single‐cell transcriptomics, and whole‐cell recordings, this work identifies the downregulation of the potassium channel KCNC3 in ...
Meng‐Ge Li, Xiao‐Bo Qian, Hai‐Long Zhang, Di Li, Ling Ji, Xin‐Chun Xu, Jia‐Sheng Ding, Li‐Jun Yin, Li Zhang, Guang‐Yin Xu, Rong Gao   +10 more
wiley   +1 more source

Cortical Network Overconnectivity Relates to Sensory, Cognitive, and Social Dimensions in Young Children With Autism Spectrum Disorder

Autism Research, EarlyView.
ABSTRACT The heterogeneity in both the neurobiological mechanisms and the phenotypic presentations of autism spectrum disorder (ASD) poses a major challenge to clinical and translational research. Alterations in functional connectivity (FC) have been associated with ASD, yet it remains unclear whether and how divergent brain network properties may ...
Borja Rodríguez‐Herreros, Ahmad Mheich, Joana Maria Almeida Osório, Sonia Richetin, Vincent Junod, Lorène Arnold, Victoria Aeschbach, Lilia Nora Adamou, Katherina Gschwend, Laura Mendes, David Romascano, Paola Yu, Marine Jequier Gygax, Anne M. Maillard, Micah M. Murray, Mahmoud Hassan, Nadia Chabane   +16 more
wiley   +1 more source