Results 21 to 30 of about 22,462 (202)

Topography of Head Direction Cells in Medial Entorhinal Cortex [PDF]

Current Biology, 2014
Neural circuits in the medial entorhinal cortex (MEC) support translation of the external environment to an internal map of space, with grid and head direction neurons providing metrics for distance and orientation.We show here that head direction cells in MEC are organized topographically.
Giocomo, Lisa M., Stensola, Tor, Bonnevie, Tora, Van Cauter, Tiffany, Moser, May-Britt, Moser, Edvard I.   +5 more
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Speed cells in the medial entorhinal cortex

Nature, 2015
Grid cells in the medial entorhinal cortex have spatial firing fields that repeat periodically in a hexagonal pattern. When animals move, activity is translated between grid cells in accordance with the animal's displacement in the environment. For this translation to occur, grid cells must have continuous access to information about instantaneous ...
Emilio Kropff, James E. Carmichael, May-Britt Moser, Edvard I. Moser   +3 more
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The medial entorhinal cortex keeps Up

Nature Neuroscience, 2012
A study reveals that medial entorhinal cortex layer III spiking dynamics shape the neocortical-hippocampal dialog during Up-Down state fluctuations in slow-wave sleep that may contribute to memory consolidation.
Dupret, D, Csicsvari, J
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Disambiguation of Overlapping Experiences by Neurons in the Medial Entorhinal Cortex [PDF]

The Journal of Neuroscience, 2007
Hippocampal neuronal activity distinguishes separate events that share common elements. Here, we examined whether the capacity to disambiguate overlapping experiences is an exclusive feature of hippocampal processing or whether information processing one stage earlier in the hippocampal system also disambiguates common elements of distinct experiences.
Paul A, Lipton, John A, White, Howard, Eichenbaum   +2 more
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Axonal synapse sorting in medial entorhinal cortex

Nature, 2017
Research on neuronal connectivity in the cerebral cortex has focused on the existence and strength of synapses between neurons, and their location on the cell bodies and dendrites of postsynaptic neurons. The synaptic architecture of individual presynaptic axonal trees, however, remains largely unknown.
Schmidt, H., Gour, A., Straehle, J., Boergens, K., Brecht, M., Helmstaedter, M., Schmidt, H. ; https://orcid.org/0000-0002-1622-6704   +6 more
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Spatial and memory circuits in the medial entorhinal cortex

Current Opinion in Neurobiology, 2015
The large capacity of episodic memory is thought to be supported by the emergence of distinct hippocampal cell assemblies for unrelated memories, such that interference is minimized. In large-scale population recordings, the orthogonal nature of hippocampal representations across environments is evident in the complete reorganization of the firing ...
Sasaki, Takuya, Leutgeb, Stefan, Leutgeb, Jill K   +2 more
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Convergent Projections from Perirhinal and Postrhinal Cortices Suggest a Multisensory Nature of Lateral, but Not Medial, Entorhinal Cortex

Cell Reports, 2019
Summary: The current model of the organization of the medial temporal lobe (MTL) episodic memory system assumes that two functionally different “where” and “what” pathways enter MTL as parallel parahippocampal cortex (PHC)-medial entorhinal cortex (MEC ...
Thanh P. Doan, Maria J. Lagartos-Donate, Eirik S. Nilssen, Shinya Ohara, Menno P. Witter   +4 more
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Production of human entorhinal stellate cell-like cells by forward programming shows an important role of Foxp1 in reprogramming

Frontiers in Cell and Developmental Biology, 2022
Stellate cells are principal neurons in the entorhinal cortex that contribute to spatial processing. They also play a role in the context of Alzheimer’s disease as they accumulate Amyloid beta early in the disease.
Tobias Bergmann, Yong Liu, Jonathan Skov, Leo Mogus, Julie Lee, Julie Lee, Ulrich Pfisterer, Louis-Francois Handfield, Andrea Asenjo-Martinez, Irene Lisa-Vargas, Stefan E. Seemann, Jimmy Tsz Hang Lee, Nikolaos Patikas, Birgitte Rahbek Kornum, Mark Denham, Poul Hyttel, Menno P. Witter, Jan Gorodkin, Tune H. Pers, Martin Hemberg, Konstantin Khodosevich, Vanessa Jane Hall   +21 more
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Cortical thickness atrophy in the transentorhinal cortex in mild cognitive impairment

NeuroImage: Clinical, 2019
This study examines the atrophy rates of subjects with mild cognitive impairment (MCI) compared to controls in four regions within the medial temporal lobe: the transentorhinal cortex (TEC), entorhinal cortex (ERC), hippocampus, and amygdala.
Sue Kulason, Daniel J. Tward, Timothy Brown, Chelsea S. Sicat, Chin-Fu Liu, J. Tilak Ratnanather, Laurent Younes, Arnold Bakker, Michela Gallagher, Marilyn Albert, Michael I. Miller   +10 more
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Structural modularity and grid activity in the medial entorhinal cortex [PDF]

Journal of Neurophysiology, 2018
Following the groundbreaking discovery of grid cells, the medial entorhinal cortex (MEC) has become the focus of intense anatomical, physiological, and computational investigations. Whether and how grid activity maps onto cell types and cortical architecture is still an open question.
Naumann, Robert K, Preston-Ferrer, Patricia, Brecht, Michael, Burgalossi, Andrea   +3 more
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