Results 11 to 20 of about 22,462 (202)
Functional network topography of the medial entorhinal cortex [PDF]
Proceedings of the National Academy of Sciences, 2021 Significance The investigation of the topographic organization of spatially coding cell types in the medial entorhinal cortex (MEC) has so far been held back by the lack of appropriate tools that enable the precise recording of both the anatomical location and activity of large populations of cells while animals forage in open ...
Horst A. Obenhaus +9 more
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Minute-scale oscillatory sequences in medial entorhinal cortex [PDF]
Nature, 2023 AbstractThe medial entorhinal cortex (MEC) hosts many of the brain’s circuit elements for spatial navigation and episodic memory, operations that require neural activity to be organized across long durations of experience1. Whereas location is known to be encoded by spatially tuned cell types in this brain region2,3, little is known about how the ...
Soledad Gonzalo Cogno +8 more
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Medial entorhinal cortex activates in a traveling wave in the rat [PDF]
eLife, 2020 Traveling waves are hypothesized to support the long-range coordination of anatomically distributed circuits. Whether separate strongly interacting circuits exhibit traveling waves remains unknown. The hippocampus exhibits traveling ‘theta’ waves and interacts strongly with the medial entorhinal cortex (MEC). To determine whether the MEC also activates
J Jesús Hernández-Pérez +2 more
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Complementary Roles of Hippocampus and Medial Entorhinal Cortex in Episodic Memory [PDF]
Neural Plasticity, 2008 Spatial mapping and navigation are figured prominently in the extant literature that describes hippocampal function. The medial entorhinal cortex is likewise attracting increasing interest, insofar as evidence accumulates that this area also contributes ...
P. A. Lipton, H. Eichenbaum
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Fan cells in lateral entorhinal cortex directly influence medial entorhinal cortex through synaptic connections in layer 1 [PDF]
eLife, 2022 Standard models for spatial and episodic memory suggest that the lateral entorhinal cortex (LEC) and medial entorhinal cortex (MEC) send parallel independent inputs to the hippocampus, each carrying different types of information.
Brianna Vandrey +4 more
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Intrinsic Bipolar Head‐Direction Cells in the Medial Entorhinal Cortex [PDF]
Advanced ScienceAbstractHead‐direction (HD) cells are a fundamental component in the hippocampal‐entorhinal circuit for spatial navigation and help maintain an internal sense of direction to anchor the orientation in space. A classical HD cell robustly increases its firing rate when the head is oriented toward a specific direction, with each cell tuned to only one ...
Xiaoyang Long +5 more
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Medial Entorhinal Cortex Excitatory Neurons Are Necessary for Accurate Timing [PDF]
The Journal of Neuroscience, 2021 The hippocampal region has long been considered critical for memory of time, and recent evidence shows that network operations and single-unit activity in the hippocampus and medial entorhinal cortex (MEC) correlate with elapsed time. However, whether MEC activity is necessary for timing remains largely unknown.
Marcelo, Dias +2 more
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Functional and structural organization of medial entorhinal cortex layer VI [PDF]
iScienceDeep layers (V/VI) of the entorhinal cortex transfer hippocampal neuronal activity to downstream neocortical networks. In addition, neurons in layer VI (LVI) of the medial entorhinal cortex (MEC) project back to all hippocampal subregions and contribute to spatial coding and memory.
Märt Rannap +5 more
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Structural development and dorsoventral maturation of the medial entorhinal cortex
eLife, 2016 We investigated the structural development of superficial-layers of medial entorhinal cortex and parasubiculum in rats. The grid-layout and cholinergic-innervation of calbindin-positive pyramidal-cells in layer-2 emerged around birth while reelin ...
Saikat Ray, Michael Brecht
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GABAergic Presubicular Projections to the Medial Entorhinal Cortex of the Rat [PDF]
The Journal of Neuroscience, 1997 We characterized presubicular neurons giving rise to bilateral projections to the medial entorhinal cortex (MEA) of the rat. Retrograde labeling of presubiculo–entorhinal projections with horseradish peroxidase and subsequent GABA immunocytochemistry revealed that 20–30% of the ipsilaterally projecting neurons are GABAergic. No GABAergic projections to
van Haeften, T. +3 more
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