Results 61 to 70 of about 24,307 (213)

Cellular mechanisms of spatial navigation in the medial entorhinal cortex

Nature Neuroscience, 2013
Neurons in the medial entorhinal cortex exhibit a grid-like spatial pattern of spike rates that has been proposed to represent a neural code for path integration. To understand how grid cell firing arises from the combination of intrinsic conductances and synaptic input in medial entorhinal stellate cells, we performed patch-clamp recordings in mice ...
Schmidt-Hieber C, Häusser M
openaire   +2 more sources

Field repetition and local mapping in the hippocampus and the medial entorhinal cortex [PDF]

Journal of Neurophysiology, 2017
Hippocampal place cells support spatial cognition and are thought to form the neural substrate of a global “cognitive map.” A widely held view is that parts of the hippocampus also underlie the ability to separate patterns or to provide different neural codes for distinct environments.
Grieves, Roddy, Duvelle, Eleonore, Wood, Emma R, Dudchenko, Paul   +3 more
openaire   +6 more sources

Mouse entorhinal cortex encodes a diverse repertoire of self-motion signals

Nature Communications, 2021
Here, the authors show that mouse medial entorhinal cortex encodes three-dimensional head movement as well as eye position and velocity. These self-motion signals are represented conjunctively in individual neurons alongside body position, running speed,
Caitlin S. Mallory, Kiah Hardcastle, Malcolm G. Campbell, Alexander Attinger, Isabel I. C. Low, Jennifer L. Raymond, Lisa M. Giocomo   +6 more
doaj   +1 more source

Shared rhythmic subcortical GABAergic input to the entorhinal cortex and presubiculum

eLife, 2018
Rhythmic theta frequency (~5–12 Hz) oscillations coordinate neuronal synchrony and higher frequency oscillations across the cortex. Spatial navigation and context-dependent episodic memories are represented in several interconnected regions including the
Tim James Viney, Minas Salib, Abhilasha Joshi, Gunes Unal, Naomi Berry, Peter Somogyi   +5 more
doaj   +1 more source

Fibronectin1‐Expressing Subicular Circuits Selectively Govern the Retrieval of Novel Object Recognition

Advanced Science, EarlyView.
Fibronectin 1 (FN1)‐expressing subicular subpopulations encode novel object preference and selectively govern retrieval of novel object recognition (NOR) via affecting excitability of entorhinal‐projecting circuit through large conductance Ca2+‐activated potassium (BK) channel. ABSTRACT Novel object recognition (NOR), referring to the cognitive ability
Fan Fei, Jiaying Shi, Jing Xi, Yixiang Xu, Shuye Ying, Xukun Fan, Wangjialu Lu, Zhisheng Li, Menghan Li, Yu Wang, Li Cheng, Lin Yang, Lingyu Xu, Zhong Chen, Cenglin Xu, Yi Wang   +15 more
wiley   +1 more source

The NMDA agonist D-cycloserine facilitates fear memory consolidation in humans [PDF]

, 2009
Animal research suggests that the consolidation of fear and extinction memories depends on N-methyl D-aspartate (NMDA)- type glutamate receptors.
Dolan, RJ, Holt, Beatrice, Holt, B., Kalisch, R, Büchel, C, Martino, Benedetto de, Büchel, Christian, Dolan, R. ; https://orcid.org/, Kalisch, R., Büchel, C., Holt, B, Klöppel, Stefan, Dolan, R.J., Petrovic, P,, Petrovic, P., Petrovic, Predrag, De Martino, B., Klöppel, S., Dolan, Raymond J., De, Martino B, Kalisch, Raffael, Klöppel, S   +21 more
core   +2 more sources

Olfactory Bulb Volume Reflects Olfactory Dysfunction and Network Organization: Insights From the Population‐Based Rhineland Study

International Forum of Allergy &Rhinology, EarlyView.
ABSTRACT Background Olfactory dysfunction is common in aging and an early symptom of neurodegenerative diseases, but how structural (olfactory bulb [OB] volume) and functional (olfactory network [OFN] functional connectivity [FC]) brain features interact to shape odor identification ability remains unclear.
Weiyi Zeng, Konstantinos Melas, Santiago Estrada, N. Ahmad Aziz, Monique M. B. Breteler   +4 more
wiley   +1 more source

Histological changes of the adult albino rats entorhinal cortex under the effect of tramadol administration: Histological and morphometric study

Alexandria Journal of Medicine, 2017
Background: Tramadol is a centrally acting synthetic analgesic agent with opioid activity. Tramadol is used to treat moderate to severe pain. The entorhinal cortex has initially attracted attention because of its strong reciprocal connections with the ...
Ibrahim K. Ragab, Hala Z.E. Mohamed
doaj   +1 more source

Multimorbidity and Associations with Cognition and Alzheimer's Disease Biomarkers

Annals of Neurology, EarlyView.
Objective Multimorbidity, the coexistence of 2 or more chronic conditions, has been linked to cognitive aging and Alzheimer's disease (AD) and AD‐related dementias, yet the mechanisms remain unclear. We aimed to examine the associations of multimorbidity with cognition and biomarkers across multiple mechanistic pathways.
Xiaqing Jiang, Sid E. O'Bryant, Robert A. Rissman, Leigh A. Johnson, Meredith N. Braskie, Kristine Yaffe, the HABS‐HD Study Team, Sid E. O'Bryant, Kristine Yaffe, Arthur Toga, Robert Rissman, Leigh Johnson, Meredith Braskie, Kevin King, James R. Hall, Melissa Petersen, Raymond Palmer, Robert Barber, Yonggang Shi, Fan Zhang, Rajesh Nandy, Roderick McColl, David Mason, Bradley Christian, Nicole Phillips, Stephanie Large, Joe Lee, Badri Vardarajan, Monica Rivera Mindt, Amrita Cheema, Lisa Barnes, Mark Mapstone, Annie Cohen, Amy Kind, Ozioma Okonkwo, Raul Vintimilla, Zhengyang Zhou, Michael Donohue, Rema Raman, Matthew Borzage, Michelle Mielke, Beau Ances, Ganesh Babulal, Jorge Llibre‐Guerra, Carl Hill, Rocky Vig   +45 more
wiley   +1 more source

Perhirhinal cortex resolves feature ambiguity in configural object recognition and perceptual oddity tasks [PDF]

, 2007
The perirhinal cortex (PRh) has a well-established role in object recognition memory. More recent studies suggest that PRh is also important for two-choice visual discrimination tasks.
Rosemary A. Cowell, Bussey, Timothy J., Cowell, Rosemary A., Timothy J. Bussey, Bartko, Susan J., Saksida, Lisa M., Boyer D. Winters, Winters, Boyer D., Lisa M. Saksida, Susan J. Bartko   +9 more
core   +1 more source