Results 71 to 80 of about 24,307 (213)

Unique deficits in place coding across subfields of the hippocampus in a mouse model of temporal lobe epilepsy

Epilepsia, EarlyView.
Abstract Objective Memory problems are comorbid with temporal lobe epilepsy (TLE). Animal models of TLE reveal impairments in spatial firing fields of hippocampal place cells, providing a potential neural substrate for memory problems. Each subfield of the hippocampus carries out unique aspects of spatial memory, yet little is known about how ...
Brittney L. Boublil, Margaret M. Donahue, Cathy B. Dang, Gergely Tarcsay, Laura A. Ewell   +4 more
wiley   +1 more source

Excitatory Microcircuits within Superficial Layers of the Medial Entorhinal Cortex [PDF]

Cell Reports, 2017
The distinctive firing pattern of grid cells in the medial entorhinal cortex (MEC) supports its role in the representation of space. It is widely believed that the hexagonal firing field of grid cells emerges from neural dynamics that depend on the local microcircuitry.
Winterer, Jochen, Maier, Nikolaus, Wozny, Christian, Beed, Prateep, Breustedt, Jörg, Evangelista, Roberta, Peng, Yangfan, D'Albis, Tiziano, Kempter, Richard, Schmitz, Dietmar   +9 more
openaire   +7 more sources

Boundary vector cells in the subiculum of the hippocampal formation [PDF]

, 2009
Stretching a familiar rectangular environment along one axis results in a stretching of place cell (PC) firing fields (“place fields”) along the same axis (O’Keefe and Burgess, 1996).
Lever, C, Jeewajee, A, O'Keefe, J, Burgess, N, Burton, S   +4 more
core   +1 more source

Entorhinal Layer II Calbindin-Expressing Neurons Originate Widespread Telencephalic and Intrinsic Projections

Frontiers in Systems Neuroscience, 2019
In the present study we provide the first systematic and quantitative hodological study of the calbindin-expressing (CB+) principal neurons in layer II of the entorhinal cortex and compared the respective projections of the lateral and medial ...
Shinya Ohara, Shinya Ohara, Michele Gianatti, Kazuki Itou, Christin H. Berndtsson, Thanh P. Doan, Takuma Kitanishi, Kenji Mizuseki, Toshio Iijima, Ken-Ichiro Tsutsui, Menno P. Witter   +10 more
doaj   +1 more source

Presurgical magnetoencephalography‐derived network control metrics distinguish successful hippocampal resection vs sparing in temporal lobe epilepsy

Epilepsia, EarlyView.
Abstract Objective Surgical decision‐making in temporal lobe epilepsy (TLE) faces a critical challenge in determining whether the hippocampus can be safely spared during anterior temporal resection, particularly when surgery involves the language‐dominant hemisphere.
Guhan Seshadri NP, Himanshu Kumar, Neha Sara John, Andreas V. Alexopoulos, Richard C. Burgess, Hiroatsu Murakami, Balu Krishnan   +6 more
wiley   +1 more source

Temporal Lobe and Frontal-Subcortical Dissociations in Non-Demented Parkinson's Disease with Verbal Memory Impairment.

PLoS ONE, 2015
ObjectiveThe current investigation examined verbal memory in idiopathic non-dementia Parkinson's disease and the significance of the left entorhinal cortex and left entorhinal-retrosplenial region connections (via temporal cingulum) on memory impairment ...
Jared J Tanner, Thomas H Mareci, Michael S Okun, Dawn Bowers, David J Libon, Catherine C Price   +5 more
doaj   +1 more source

Excellent Interrater Reliability for Manual Segmentation of the Medial Perirhinal Cortex

Brain Sciences, 2023
Objective: Evaluation of interrater reliability for manual segmentation of brain structures that are affected first by neurofibrillary tau pathology in Alzheimer’s disease.
Nicolas A. Henzen, Julia Reinhardt, Maria Blatow, Reto W. Kressig, Sabine Krumm   +4 more
doaj   +1 more source

Ultrafast oscillations in the human brain and their functional significance

Epilepsia, EarlyView.
Abstract Objective The upper frequency limit of human brain activity remains unknown. Using ultrahigh sampling rate (≥20 kHz) intracranial microelectroencephalography, this study aimed to systematically explore and quantitatively characterize brain field oscillations beyond the established high‐frequency oscillation range (>2 kHz), and to determine ...
Milan Brázdil, Vojtěch Trávníček, Jonathan Curot, Martin Pail, Monika Służewska‐Niedźwiedź, Robert Roman, Filip Plešinger, Emmanuel Barbeau, Michal Kucewicz, Petr Klimeš, Jan Cimbálník, Pavel Jurák, William C. Stacey, Gregory A. Worrell   +13 more
wiley   +1 more source

Perceptual functions of perirhinal cortex in rats: zero-delay object recognition and simultaneous oddity discriminations [PDF]

, 2007
The perirhinal cortex (PRh) is widely accepted as having an important role in object recognition memory in humans and animals. Contrary to claims that PRh mediates declarative memory exclusively, previous evidence suggests that PRh has a role in the ...
Bussey, Timothy J., Cowell, Rosemary A., Bartko, Susan J., Saksida, Lisa M., Winters, Boyer D.   +4 more
core   +1 more source

Synaptic responses in superficial layers of medial entorhinal cortex from rats with kainate-induced epilepsy

Neurobiology of Disease, 2007
Mesial temporal lobe epilepsy patients often display shrinkage of the entorhinal cortex, which has been attributed to neuronal loss in medial entorhinal cortex layer III (MEC-III).
Else A. Tolner, Christiane Frahm, Robert Metzger, Jan A. Gorter, Otto W. Witte, Fernando H. Lopes da Silva, Uwe Heinemann   +6 more
doaj   +1 more source