Results 71 to 80 of about 22,462 (202)

Recurrent circuits within medial entorhinal cortex superficial layers support grid cell firing

Nature Communications, 2018
Medial entorhinal cortex (mEC) neurons encode various navigation parameters such as speed, head direction, as well as grid cells. Here, the authors demonstrate that brief disruption of the local activity in mEC specifically affects grid cell tuning.
Ipshita Zutshi, Maylin L. Fu, Varoth Lilascharoen, Jill K. Leutgeb, Byung Kook Lim, Stefan Leutgeb   +5 more
doaj   +1 more source

Multisynaptic inputs from the medial temporal lobe to V4 in macaques. [PDF]

PLoS ONE, 2012
Retrograde transsynaptic transport of rabies virus was employed to undertake the top-down projections from the medial temporal lobe (MTL) to visual area V4 of the occipitotemporal visual pathway in Japanese monkeys (Macaca fuscata). On day 3 after rabies
Taihei Ninomiya, Hiromasa Sawamura, Ken-Ichi Inoue, Masahiko Takada   +3 more
doaj   +1 more source

Greater Motor and Nonmotor Burden at Diagnosis Is Associated With Amyloid Copathology in Parkinson's Disease

Movement Disorders, EarlyView.
Abstract Background Concurrent Alzheimer's disease pathology is increasingly recognized as a poor prognostic factor in Parkinson's disease (PD), yet reliable clinical indicators for early identification of AD copathology remain poorly established.
Han Kyu Na, Yeeun Sun, Chan Wook Park, Jung Hyun Lee, Yun Young Choi, Quynh Phuong Vo, Seok Jong Chung, Han Soo Yoo, Chul Hyoung Lyoo, Young H. Sohn, Jin Yong Hong, Phil Hyu Lee   +11 more
wiley   +1 more source

Associations of cannabis use, tobacco use and co‐use with brain volume: A systematic review and meta‐analysis

Addiction, EarlyView.
Abstract Background and aims Cannabis is the most widely used illicit drug worldwide and is often co‐used with tobacco, the leading cause of preventable death. Although cannabis and tobacco have distinct neurobiological actions, their associations with brain volumes are unclear.
Katherine Sawyer, Tom P. Freeman, Martine Skumlien, Esther Walton, Thomas Lancaster, Jorien L. Treur, Valentina Lorenzetti, Anna K. M. Blackwell, Chloe Burke, Richie J. Carr, Constantinos Constantinides, Maisie Cox, Sarah Dance, Shadi Daryan, Sorcha Hamilton, Tom Jenkins, Gemma M. J. Taylor   +16 more
wiley   +1 more source

Excitatory Postrhinal Projections to Principal Cells in the Medial Entorhinal Cortex [PDF]

The Journal of Neuroscience, 2015
The postrhinal cortex (POR) provides substantial input to the entorhinal cortex, mainly targeting superficial layers of the medial entorhinal cortex (MEC). Major inputs to POR originate in the visual and parietal cortex, thus providing neurons in MEC with a subset of cortical information relevant to their spatial firing properties.
Noriko, Koganezawa, Ragnhild, Gisetstad, Ellen, Husby, Thanh P, Doan, Menno P, Witter   +4 more
openaire   +2 more sources

Human brain matters: Navigating the neuropathology of COVID‐19

Brain Pathology, EarlyView.
Severe COVID‐19 is associated with vascular dysregulation and chronic neuroinflammation, leading to axonal injury and neurodegeneration. In long COVID or PASC, persistent alterations in neuroimaging and biofluid biomarkers reflect ongoing neuronal damage and neuroinflammation, contributing to long‐term neurological symptoms including fatigue, cognitive
Juliana M. Nieuwland, Angelica Scaramuzza, Marianna Bugiani, Wilma D. J. van de Berg, Jinte Middeldorp   +4 more
wiley   +1 more source

Non‐Alzheimer Aβ deposits in the human CNS: Implications with hypoxia and related conditions

Brain Pathology, EarlyView.
An Aβ deposit in a non‐Alzheimer's brain from an individual who experienced hypoxia/energy failure. Abstract We recently reported the deposition of Aβ in the frontal cortex of individuals who died of acute coronavirus disease 2019 (COVID‐19), or who did not have COVID‐19 but had respiratory distress, or infants with severe cardiac malformations.
Esma Karlovich, David S. Priemer, Charles Harker Rhodes, Daniel P. Perl, Kurenai Tanji, James E. Goldman   +5 more
wiley   +1 more source

Stereotyped network dynamics in the medial entorhinal cortex

, 2020
Poster for FENS2020.The medial entorhinal cortex (MEC) supports the brain’s representation of space with distinct cell types (grid, border, object-vector, head-directions and speed cells). Since no single sensory stimulus can faithfully predict the firing of these cells, attractor network models postulate that spatially-tuned firing emerges from ...
Cogno, Soledad Gonzalo, Donato, Flavio, Obenhaus, Horst A., R. Irene Jacobsen, May-Britt Moser, Moser, Edvard I.   +5 more
openaire   +1 more source

Functional topography of the human entorhinal cortex

eLife, 2015
Despite extensive research on the role of the rodent medial and lateral entorhinal cortex (MEC/LEC) in spatial navigation, memory and related disease, their human homologues remain elusive.
Tobias Navarro Schröder, Koen V Haak, Nestor I Zaragoza Jimenez, Christian F Beckmann, Christian F Doeller   +4 more
doaj   +1 more source

Clinicopathological and molecular heterogeneity of amyloid‐β in unnatural deaths under 70 years: A forensic autopsy–based study

Brain Pathology, EarlyView.
This study investigates amyloid‐beta (Aβ) pathology in a forensic autopsy cohort of relatively young individuals (40–69 years). Using detailed immunohistochemical analyses of multiple Aβ species, we demonstrate marked regional and molecular heterogeneity, particularly within the striatum.
Shojiro Ichimata, Yukiko Hata, Koji Yoshida, Ryo Tanaka, Shigeo Murayama   +4 more
wiley   +1 more source