Results 141 to 150 of about 27,250 (275)

Malignant phyllodes tumours of the breast: the case for revising WHO’s ‘full house’ diagnostic criteria

open access: yesHistopathology, Volume 87, Issue 2, Page 169-182, August 2025.
This review explores the histological criteria used in classifying malignant phyllodes tumours, current evidence gaps in relation to their metastatic potential and survey data of international breast pathologists to propose a refined diagnostic approach.
Puay Hoon Tan   +41 more
wiley   +1 more source

Safety, Tolerability, Efficacy, Pharmacokinetics, and Pharmacodynamics of Afimetoran, a Toll‐Like Receptor 7 and 8 Inhibitor, in Patients With Cutaneous Lupus Erythematosus: A Phase 1b Randomized, Double‐Blind, Placebo‐Controlled Study

open access: yesACR Open Rheumatology, Volume 7, Issue 7, July 2025.
Objective There is an unmet need for safe and effective oral treatments for cutaneous lupus erythematosus (CLE). Afimetoran is an investigational, first‐in‐class, orally bioavailable, selective small molecule inhibitor of Toll‐like receptors (TLRs) 7 and 8.
Fareeda Hosein   +13 more
wiley   +1 more source

Prognostic factors for patients with esophageal cancer who achieve pathological complete response in the primary tumor after upfront chemotherapy or chemoradiotherapy

open access: yesAnnals of Gastroenterological Surgery, Volume 9, Issue 4, Page 678-686, July 2025.
Male gender and pathological lymph node metastasis are independent poor prognostic factors in patients with esophageal cancer who receive upfront treatment followed by surgery and achieved pathological complete response of the primary tumor. Among patients without pathological lymph node metastasis, the upfront chemotherapy group showed significantly ...
Masaaki Motoori   +9 more
wiley   +1 more source

Pulmonary Blastoma: A Case Report and Review of the Literature

open access: yesClinical Case Reports, Volume 13, Issue 7, July 2025.
ABSTRACT This report aimed to underscore the significance of pulmonary blastoma, a rare entity with limited literature, by contributing insights into its clinical features, diagnostic approaches, and treatment modalities. Additionally, it emphasizes the critical role of a multidisciplinary approach in the effective management of this complex and ...
Haseeb Ahsin   +4 more
wiley   +1 more source

First‐in‐human phase 1 study of KHK2455 monotherapy and in combination with mogamulizumab in patients with advanced solid tumors

open access: yesCancer, Volume 131, Issue 13, 1 July 2025.
Abstract Background Indoleamine 2,3‐dioxygenase 1 (IDO1) is a heme‐containing enzyme that degrades tryptophan (Trp) to kynurenine (Kyn), which suppresses effector T cells and reduces antitumor activity. KHK2455 is a long‐acting selective IDO1 inhibitor that blocks the heme component of the IDO holoenzyme.
Timothy A. Yap   +16 more
wiley   +1 more source

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