Results 81 to 90 of about 26,138 (325)

Engineering antibodies with cancer‐associated binding sites

BMEMat, EarlyView.
This review describes antibodies that perform direct/indirect roles in cancer treatment by binding to effective targets and discusses how antibodies kill tumors and modulate tumor microenvironment through these targets. The classification of expression systems for antibody production is summarized to guide appropriate selection based on different ...
Yinqi Tian, Yumeng Pan, Yingchun Zhang, Fangling Wang, Zejun Wang   +4 more
wiley   +1 more source

Lenvatinib rechallenge in a patient with advanced thymic carcinoma: A case report

Thoracic Cancer, Volume 13, Issue 23, Page 3408-3411, December 2022., 2022
We present a case treated with “lenvatinib rechallenge” for advanced thymic carcinoma who was previously treated with lenvatinib followed by multiple cytotoxic agents. Shortly after lenvatinib rechallenge, rapid pleural and pericardial effusion reduction was observed. Our case might suggest lenvatinib rechallenge as a treatment option for patients with
Yuto Terashima, Taiki Hakozaki, Susumu Takeuchi, Yukio Hosomi   +3 more
wiley   +1 more source

A Hierarchical Transformer Encoder to Improve Entire Neoplasm Segmentation on Whole Slide Image of Hepatocellular Carcinoma [PDF]

arXiv, 2023
In digital histopathology, entire neoplasm segmentation on Whole Slide Image (WSI) of Hepatocellular Carcinoma (HCC) plays an important role, especially as a preprocessing filter to automatically exclude healthy tissue, in histological molecular correlations mining and other downstream histopathological tasks.
arxiv  

Early recurrence factors in patients with stage III non‐small cell lung cancer treated with concurrent chemoradiotherapy

Thoracic Cancer, Volume 13, Issue 24, Page 3451-3458, December 2022., 2022
Clinical characteristics and risk factors for recurrence have not previously been well defined in the early recurrence group for patients with unresectable LA‐NSCLC who underwent CRT. Based on the results of our study, lower tumor proportion score may be predictors of early recurrence following concurrent chemoradiotherapy (CRT) for unresectable ...
Yutaka Takahara, Takuya Tanaka, Yoko Ishige, Ikuyo Shionoya, Kouichi Yamamura, Takashi Sakuma, Kazuaki Nishiki, Keisuke Nakase, Masafumi Nojiri, Ryo Kato, Shohei Shinomiya, Taku Oikawa, Shiro Mizuno   +12 more
wiley   +1 more source

Thymic carcinoma

Clinical and Biomedical Research, 2016
Thymic carcinomas are a heterogeneous group of aggressive, invasive epithelial malignancies. Their incidence is rare, occurring predominantly in middle-aged men. Here we present the typical imaging findings of a thymic carcinoma.
Vitória Homem Machado, Fernando Pivatto Júnior, Felipe Soares Torres   +2 more
doaj   +2 more sources

Primary malignant teratoma of the mediastinum with poor outcome: A case report [PDF]

Vojnosanitetski Pregled, 2018
Introduction. About 5%–10% of mediastinal tumors in adults are teratomas and about 85% of them are benign. Case report. We report a case of extragonadal malignant teratoma in a 39-year old man.
Sazdanić-Velikić Danica, Škrbić Dušan, Považan Đorđe, Đurić Mirna, Vučković Dejan, Sečen Nevena   +5 more
doaj   +1 more source

First‐in‐Human Single and Multiple Ascending Dose Studies of Balinatunfib, a Small Molecule Inhibitor of TNFR1 Signaling in Healthy Participants

Clinical Pharmacology &Therapeutics, EarlyView.
Oral small molecule inhibitors of tumor necrosis factor alpha (TNFα) are emerging as attractive therapeutic agents for the treatment of various autoimmune diseases. Balinatunfib (SAR441566), a novel oral inhibitor of tumor necrosis factor receptor 1 (TNFR1) signaling, changes the configuration of the soluble TNFα (sTNFα) trimer and prevents its ...
Nassr Nassr, Faiza Rharbaoui, Dietmar Weitz, Johann Gassenhuber, Markus Rehberg, Markus Kohlmann, Fabienne Schumacher, Amel Lahmar, Andreas Kovar, Laurent Perrin, Frank‐Dietrich Wagner, Maria Wiekowski, Mai Anh Nguyen   +12 more
wiley   +1 more source

Factors related to the diagnosis of lung cancer by transbronchial biopsy with endobronchial ultrasonography and a guide sheath

Thoracic Cancer, Volume 13, Issue 24, Page 3459-3466, December 2022., 2022
The present study showed that size of targeted lesion, especially diameter ≥20 mm, the bronchus sign, and detection on EBUS imaging were significant contributors to making the diagnosis of lung cancer by TBB with EBUS‐GS. In addition, the odds ratio (OR) of detection on EBUS imaging for the diagnosis of lung cancer with EBUS‐GS tended to be higher than
Yuki Kurihara, Hiroki Tashiro, Koichiro Takahashi, Ryo Tajiri, Yuki Kuwahara, Kokoro Kajiwara, Natsuko Komiya, Shinsuke Ogusu, Chiho Nakashima, Tomomi Nakamura, Shinya Kimura, Naoko Sueoka‐Aragane   +11 more
wiley   +1 more source

Cytologic Diagnoses of Lung Adenocarcinoma With Concomitant Metastasis From a Different Primary: A Case Series

Diagnostic Cytopathology, EarlyView.
ABSTRACT Lung adenocarcinoma is a common malignancy that can metastasize. The lung is also a common site for metastasis from other sites. Prompt and accurate diagnosis is critical for patient management. The diagnosis of lung adenocarcinoma can be occasionally challenging due to overlapping clinical and pathological features with adenocarcinomas from ...
Robert Pei, Shane M. Woods, Brant G. Wang   +2 more
wiley   +1 more source

Segmentectomy for clinically early‐stage primary squamous cell carcinoma of the lung

Thoracic Cancer, Volume 13, Issue 24, Page 3477-3485, December 2022., 2022
No significant differences were observed in the cumulative incidence of recurrence (CIR) between patients who underwent lobectomy and those who underwent segmentectomy. Multivariable analysis was performed for CIR using the propensity score; it revealed that segmentectomy was not a significant predictor of worse CIR.
Atsushi Kagimoto, Yasuhiro Tsutani, Yoshihisa Shimada, Takahiro Mimae, Yoshihiro Miyata, Hiroyuki Ito, Haruhiko Nakayama, Norihiko Ikeda, Morihito Okada   +8 more
wiley   +1 more source