Results 91 to 100 of about 576,017 (266)

Impacts of Rural–Urban Labour Transfer and Land Transfer on Land Efficiency in China: A Analysis of Mediating Effects

Land
In the midst of China’s ongoing rural–urban integration and development, a pivotal transformation involving the realignment of labour dynamics and land utilisation is underway.
Siyi Pei, Sudan Zhao, Xuan Li, Jiahui Li
doaj   +1 more source

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas F. Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

The Mediating Effect of Vitamin D on the Association Between Exercise and Triglyceride in Adolescents: A Prospective Cross-sectional Study

Xiehe Yixue Zazhi
ObjectiveTo investigate the mediating role of vitamin D in the association between exerciseand triglyceride among adolescents, as well as its potential molecular mechanisms.MethodsThis prospective cross-sectional study utilized convenience sampling ...
HUANG Bochuan, GUO Xiaoyuan, WANG Yutong, LIU Jiaxuan, PAN Hui, CHEN Shi   +5 more
doaj   +1 more source

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source

Activities of daily living mediate the association between balance and falls in middle aged and older adults

Scientific Reports
Falls constitute a significant public health issue affecting middle-aged and older adults.The consequences of falls extend beyond physical injuries and compromised quality of life to encompass psychological and socioeconomic dimensions.
Jiaran Jiang, Quan Zhou, Chuanxia Zhang, Keer Cong   +3 more
doaj   +1 more source

The impact of the sports industry on the development of the health industry: an exploration of mediating and threshold effects

Frontiers in Public Health
IntroductionThe sports and health industries play a crucial role in fulfilling individuals' aspirations for an enhanced quality of life and in supporting the development of a Healthy China.MethodsTo explore the impact mechanism of the sports industry ...
Shutong Zhao, Shutong Zhao, Haiyan Huang
doaj   +1 more source

Decoding the dynamic extracellular matrix in cancer—3D models and bioscaffolds rewire the rules of tumor progression

FEBS Letters, EarlyView.
Cancer progression is regulated by the dynamic matrix code of the tumor microenvironment, which influences cellular behavior and disease development. Importantly, matrix remodeling in three‐dimensional cancer models more accurately reflects in vivo conditions compared to conventional two‐dimensional systems.
Sylvia Mangani, Konstantinos Spanopoulos, Zoi Piperigkou, Nikos K. Karamanos   +3 more
wiley   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Prognosis, Effect Modification, and Mediation [PDF]

European Urology, 2018
Andrew J, Vickers, Gunnar, Steineck
openaire   +2 more sources