Results 101 to 110 of about 3,869,309 (345)

OBSERVATIONS ON ITCHING PRODUCED BY COWHAG, AND ON THE PART PLAYED BY HISTAMINE AS A MEDIATOR OF THE ITCH SENSATION [PDF]

, 1953
J. L. BROADBENT
openalex   +1 more source

Plasmodium falciparum gametogenesis essential protein 1 (GEP1) is a transmission‐blocking target

FEBS Letters, EarlyView.
This study shows Plasmodium falciparum GEP1 is vital for activating sexual stages of malarial parasites even independently of a mosquito factor. Knockout parasites completely fail gamete formation even when a phosphodiesterase inhibitor is added. Two single‐nucleotide polymorphisms (V241L and S263P) are found in 12%–20% of field samples.
Frederik Huppertz, Milagros Siebeck Caturelli, Lina S. Lehmann, Florian Kurth, Alexander G. Maier, Kai Matuschewski   +5 more
wiley   +1 more source

4‐nitrobenzoate inhibits 4‐hydroxybenzoate polyprenyltransferase in malaria parasites and enhances atovaquone efficacy

FEBS Letters, EarlyView.
Atovaquone is an antimalarial requiring potentiation for sufficient efficacy. We pursued strategies to enhance its activity, showing that 4‐nitrobenzoate inhibits 4‐hydroxybenzoate polyprenyltransferase, decreasing ubiquinone biosynthesis. Since atovaquone competes with ubiquinol in mitochondria, 4‐nitrobenzoate facilitates its action, potentiating ...
Ignasi Bofill Verdaguer, Matheus Felipe Santos, Maurício Mazzine Filho, Gabriela Oliveira Castro, Agustín Hernández, Manoel Aparecido Peres, Alejandro Miguel Katzin, Marcell Crispim   +7 more
wiley   +1 more source

The Place of Arbitration and Mediation in Ancient Systems of International Ethics [PDF]

, 1908
Louise E. Matthael
openalex   +1 more source

Linked dimers of the AAA+ ATPase Msp1 reveal energetic demands and mechanistic plasticity for substrate extraction from lipid bilayers

FEBS Letters, EarlyView.
Cells must clear mislocalized or faulty proteins from membranes to survive. The AAA+ ATPase Msp1 performs this task, but dissecting how its six subunits work together is challenging. We engineered linked dimers with varied numbers of functional subunits to reveal how Msp1 subunits cooperate and use energy to extract proteins from the lipid bilayer ...
Deepika Gaur, Brian Acquaviva, Baylee A. Smith, Nathan Walker, Isabella Walter, Matthew L. Wohlever   +5 more
wiley   +1 more source

Fictional Characters as Story-Free Denoting Concepts

Humanities
Some realist views about fiction are non-objectual in that they see fictional characters not as objects but rather as properties or the like; notably, kinds, roles, or denoting concepts.
Francesco Orilia
doaj   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Artificial Intelligence at the Service of Digital Archiving: Optimization of Practices and Ethical Challenges

Journal of Information Sciences
Digital archiving has undergone a significant evolution in recent years, shifting from a traditional approach to a more computational one. Faced with the explosion of digital data and documents, traditional archiving methods are being overtaken. In this
Nora SAAD, Noureddine ELMQADDEM, Edouard VASSEUR   +2 more
doaj   +1 more source

Mediated generalization and the interpretation of verbal behavior: V. 'Free association' as related to differences in professional training. [PDF]

, 1943
J. P. Foley, Zachary MacMillan
openalex   +1 more source