Results 121 to 130 of about 1,894,725 (339)

Human mesenchymal stem cells (MSCs) for treatment towards immune- and inflammation-mediated diseases: review of current clinical trials [PDF]

, 2016
Li‐Tzu Wang, Chiao-Hsuan Ting, Ming‐Shyen Yen, Ko‐Jiunn Liu, Huey‐Kang Sytwu, Kenneth K. Wu, B. Linju Yen   +6 more
openalex   +1 more source

Interplay between circadian and other transcription factors—Implications for cycling transcriptome reprogramming

FEBS Letters, EarlyView.
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley   +1 more source

Fictional Characters as Story-Free Denoting Concepts

Humanities
Some realist views about fiction are non-objectual in that they see fictional characters not as objects but rather as properties or the like; notably, kinds, roles, or denoting concepts.
Francesco Orilia
doaj   +1 more source

Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer

FEBS Letters, EarlyView.
Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani, Noemi E. Nwosu, Viktoria Gocke, Müge Kasanmascheff, Hannes Mutschler   +4 more
wiley   +1 more source

Artificial Intelligence at the Service of Digital Archiving: Optimization of Practices and Ethical Challenges

Journal of Information Sciences
Digital archiving has undergone a significant evolution in recent years, shifting from a traditional approach to a more computational one. Faced with the explosion of digital data and documents, traditional archiving methods are being overtaken. In this
Nora SAAD, Noureddine ELMQADDEM, Edouard VASSEUR   +2 more
doaj   +1 more source

Supersymmetry breaking

, 2006
These lectures provide a simple introduction to supersymmetry breaking. After presenting the basics of the subject and illustrating them in tree-level examples, we discuss dynamical supersymmetry breaking, emphasizing the role of holomorphy and ...
Affleck, Affleck, Affleck, Cordes, Dine, Dine, Fayet, Ferrara, Giudice, Giudice, Giudice, Grisaru, Harnik, Intriligator, Intriligator, Katz, Luty, Meurice, Nir, ORaifeartaigh, Pomarol, Poppitz, Randall, Seiberg, Shadmi, Wess, Wess, Witten   +27 more
core   +2 more sources

Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing

FEBS Letters, EarlyView.
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Mediation, Self-Represented Parties, and Access to Justice: Getting There from Here [PDF]

, 2019
Mediation is enthusiastically promoted as a vehicle for providing access to justice. This is as true in developing countries as it is in the United States.
Nolan-Haley, Jacqueline
core   +1 more source