Results 141 to 150 of about 792,576 (296)

Plasma extrachromosomal circular DNA as a biomarker in EGFR‐targeted therapy of non‐small cell lung cancer

Molecular Oncology, EarlyView.
Detection of extrachromosomal circular DNA (eccDNA) in plasma samples from EGFR‐mutated non‐small cell lung cancer patients. Plasma was collected before and during treatment with the EGFR‐tyrosine kinase inhibitor osimertinib. Plasma eccDNA was detected in all cancer samples, and the presence of the EGFR gene on eccDNA serves as a potential biomarker ...
Simone Stensgaard, Sarmad Mehmood, Eva Boysen Fynboe Ebert, Peter Meldgaard, Anindya Dutta, Boe S. Sorensen   +5 more
wiley   +1 more source

Examining communalism in the home math environment to understand its role in predicting children’s mathematics development

Frontiers in Psychology
This study investigated the structure of the home math environment (HME) of preschoolers. Examinations include the relation between parental communal beliefs, home math engagement, children’s math skill development, and whether communal beliefs mediated ...
Tamika L. McElveen, Annahita Modirrousta, Carlie Fox, John Day, Sophie Salerno, Abby Murchland   +5 more
doaj   +1 more source

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

Exploring self-rated health, physical activity, and social anxiety among female Chinese university students: a variable- and person-centered analysis

Frontiers in Public Health
BackgroundPhysical inactivity is a significant public health issue among female college students. This study aimed to explore the complex relationship between self-rated health (SRH), social anxiety (SA), and physical activity (PA) in a sample of female ...
Wenying Huang, Bin Chen, Chang Hu
doaj   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Research on the influence mechanism of health anxiety on hypochondriasis in older adults from the perspective of digital health literacy theory: mediated by information search

Frontiers in Public Health
ObjectiveThis study aims to elucidate the correlations among health information search, health anxiety, and geriatric hypochondriasis, and to examine the mediating role of health information search behavior between health anxiety and hypochondriasis ...
Aojie Chen, Xiquan Wang
doaj   +1 more source

Cis‐regulatory and long noncoding RNA alterations in breast cancer – current insights, biomarker utility, and the critical need for functional validation

Molecular Oncology, EarlyView.
The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués, Aracele Martinez‐Mendez, John Crown, Alex Eustace   +3 more
wiley   +1 more source

The impact of physical activity and dietary behavior on depression in college students: a study on mediation effects and network analysis

Frontiers in Public Health
ObjectivesThis study investigates the relationships between physical activity, dietary behavior, and depressive symptoms among college students, focusing on the mediating role of dietary behavior and interconnections revealed by network analysis ...
Wen Zhang, Wenying Huang, Chang Hu, Yuqing Yuan, Xinyi Chen   +4 more
doaj   +1 more source

Causal mediation analysis in presence of multiple mediators uncausally related

, 2019
Mediation analysis aims at disentangling the effects of a treatment on an outcome through alternative causal mechanisms and has become a popular practice in biomedical and social science applications.
Alarcon, Flora, Baglietto, Laura, Birmele, Etienne, Jerolon, Allan, Perduca, Vittorio   +4 more
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