Results 131 to 140 of about 800,077 (295)

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Role of PD-L1 in mediating the effect of lipid on ulcerative colitis: a mediation Mendelian randomization study

Frontiers in Genetics
IntroductionRecent evidence suggests that lipids play a crucial role in intestinal metabolic balance and are closely linked to ulcerative colitis (UC). However, the mechanisms underlying their effects remain unclear.
Peihong Li, Yiwen Wang, Hongyi Hu, Boyun Sun   +3 more
doaj   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Health-related quality of life in children born preterm at school age: the mediating role of social support and maternal stress

Frontiers in Psychology
Research on health-related quality of life (HRQoL) of school-aged children born preterm (< 37 weeks of gestational age) is scarce and there are few studies examining the relationship with medical and family factors. The aims were to analyze HRQoL in a
Melissa Liher Martínez-Shaw, Melissa Liher Martínez-Shaw, Kari Anne I. Evensen, Kari Anne I. Evensen, Kari Anne I. Evensen, Sandra Melero, Sandra Melero, Yolanda Sánchez-Sandoval, Yolanda Sánchez-Sandoval   +8 more
doaj   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Effects of different types of milk consumption on Crohn's disease and the mediating effects of amino acids: A Mendelian randomization study

Journal of Dairy Science
: Dietary therapy is a common adjunctive treatment for Crohn's disease (CD). However, previous studies have presented conflicting views on whether dairy products should be included in dietary therapy.
Wen-Jiang Zhao, Qing-Ao Xiao
doaj   +1 more source

Mediation Analysis with Multiple Exposures and Multiple Mediators

Statistics in Medicine
ABSTRACTA mediation analysis approach is proposed for multiple exposures, multiple mediators, and a continuous scalar outcome under the linear structural equation modeling framework. It assumes that there exist orthogonal components that demonstrate parallel mediation mechanisms on the outcome, and thus is named principal component mediation analysis ...
openaire   +3 more sources

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

A network and mediation analysis on the associations between family environment and suicidal ideation in adolescents in a psychiatric clinical setting

Frontiers in Psychiatry
BackgroundFamily environmental factors are known to contribute to adolescent suicidal ideation (SI), but how these factors interact and relate to SI needs further investigation.AimsTo examine how family factors interact with each other and are associated
Xing-Yan Liu, Shu-Hui Xu, Wen-Jing Yan, Li-Li Zhu, Cheng-Han Li   +4 more
doaj   +1 more source

Subgroup Mediation Analysis

Stat
ABSTRACTImaging genetics–based mediation analysis provides a powerful approach to understanding gene–brain–cognition pathways. However, despite recent progress, several challenges involving group‐level and subject‐level heterogeneity remain largely unaddressed.
Kaizhou Lei, Shengxian Ding, Lexin Li, Chao Huang   +3 more
openaire   +1 more source