Results 141 to 150 of about 22,390,894 (295)

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

A network and mediation analysis on the associations between family environment and suicidal ideation in adolescents in a psychiatric clinical setting

Frontiers in Psychiatry
BackgroundFamily environmental factors are known to contribute to adolescent suicidal ideation (SI), but how these factors interact and relate to SI needs further investigation.AimsTo examine how family factors interact with each other and are associated
Xing-Yan Liu, Shu-Hui Xu, Wen-Jing Yan, Li-Li Zhu, Cheng-Han Li   +4 more
doaj   +1 more source

Mediation Analysis for Probabilities of Causation

Proceedings of the AAAI Conference on Artificial Intelligence
Probabilities of causation (PoC) offer valuable insights for informed decision-making. This paper introduces novel variants of PoC-controlled direct, natural direct, and natural indirect probability of necessity and sufficiency (PNS). These metrics quantify the necessity and sufficiency of a treatment for producing an outcome, accounting for different ...
Yuta Kawakami, Jin Tian
openaire   +3 more sources

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source

Mala flavor preference increases risk of excessive gestational weight gain mediated by high-carbohydrate dietary patterns in Chongqing, China: an ambispective cohort study

Frontiers in Nutrition
Taste preference drives food selection, acceptance, or rejection and influences nutritional status and body mass index. Nevertheless, there are few reports concerning pregnant women.
Jinghua Li, Difei Wang, Yanyan Mao, Wuxia Zhang, Qianxi Zhu, Jun Liu, Jing Du, Weijin Zhou, Weijin Zhou, Fen Wang, Min Li   +10 more
doaj   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

The mediating effect of self-perceived aging on social capital and depression among Chinese community-dwelling older adult: a cross-sectional study

Frontiers in Public Health
BackgroundAmid an aging society, boosting older adult social capital is crucial to meet their growing health needs. This could be an effective way to alleviate the shortage of public health resources and improve the mental health of the older adult ...
Yuguo Ye, Hui Liu, Ziming Wang, Qianwei Zhang, Shifan Yang, Lian Yang   +5 more
doaj   +1 more source

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

Mediation Analysis in Experimental Research

, 2018
This chapter introduces the conceptual and statistical basics of mediation analysisin the context of experimental research. Adopting the respective terminology,mediation analysis can be referred to as an array of quantitative methods developedto ...
Koschate-Fischer, Nicole, Schwille, Elisabeth   +1 more
core  

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source