Results 121 to 130 of about 22,390,894 (295)
Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions
FEBS Letters, EarlyView.The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang +4 more
wiley +1 more source
Frontiers in OncologyObjectiveLung cancer, the most prevalent malignancy, is typically diagnosed at an advanced stage. Smoking is a pivotal risk factor for NSCLC, yet the impact of various smoking statuses on NSCLC remains unclear.
Zhenghua Cao +8 more
doaj +1 more source
An analysis of local solicitors’ attitudes to and use of mediation [PDF]
, 2014 Legal practitioners are considered to be the “gate-keepers” for a significant proportion of the mediation work currently being undertaken in the UK. This small-scale study undertaken in Canterbury explores the attitudes of local legal practitioners to ...
Howland, A., Waters, B.
core
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
Frontiers in EndocrinologyBackgroundThis study aimed to determine the correlation of plasma asprosin with anthropometric and metabolic parameters in Korean children and adolescents.MethodsThis single-center study included 109 Korean children and adolescents: 62 (56.9%) obese ...
Shin-Hee Kim +2 more
doaj +1 more source
An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes
FEBS Letters, EarlyView.GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg +14 more
wiley +1 more source
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
The Mediating Role of Patience in the Relationship Between Coping Styles and Resilience
Anadolu Üniversitesi Eğitim Fakültesi dergisiTThe aim of the present study was to examine the mediation effect of patience in the relationship between coping styles and resilience in university students. The sample comprised 401 university students (290 females [72.3%] and 111 males [27.7%]).
Özlem Çakmak Tolan, Muhammed Sevilgen
doaj +1 more source
Divorce mediation : factors influencing the choice of mediation and their respective objective and subjective outcomes [PDF]
, 1985 Using a decisioning paradigm based on exchange and conflict theories, this. study analyzed the data from 200 couples involved in the Denver custody Mediation Project.
Deal, Tony Ray +1 more
core
Discerning protein pools by selective staining with self‐labeling tags
FEBS Letters, EarlyView.Cell surface proteins have an intra‐ and extracellular pool. Combining genetic fusion to self‐labeling tags that can be addressed with small molecule fluorophores allows separating these pools. We highlight recent developments and techniques for state‐of‐the‐art interrogation of cell surface proteins in the complex tissue setting.
Kati Fischermanns, Johannes Broichhagen
wiley +1 more source