Results 111 to 120 of about 178,060 (260)

Phosphoinositides and inositol phosphates as molecular glues

FEBS Letters, EarlyView.
Inositol phosphates (IPs) and phosphoinositides (PIPs) regulate diverse eukaryotic processes. Beyond recruiting signaling proteins or acting as structural cofactors, recent studies suggest they mediate protein–protein interactions as natural molecular glues.
Aleshia Seaton‐Terry, Alexander J. Cutright, Mong Na Claire Loi, Jessica Martin, Joseph W. Gilligan, Jakub N. Kubina, Michael J. Arambula, Susanna Tanada Palmu, Daniella Zhou, Raymond D. Blind   +9 more
wiley   +1 more source

Mala flavor preference increases risk of excessive gestational weight gain mediated by high-carbohydrate dietary patterns in Chongqing, China: an ambispective cohort study

Frontiers in Nutrition
Taste preference drives food selection, acceptance, or rejection and influences nutritional status and body mass index. Nevertheless, there are few reports concerning pregnant women.
Jinghua Li, Difei Wang, Yanyan Mao, Wuxia Zhang, Qianxi Zhu, Jun Liu, Jing Du, Weijin Zhou, Weijin Zhou, Fen Wang, Min Li   +10 more
doaj   +1 more source

PARK(ing) time–How park deficiency affects the biological clock in a Drosophila model of Parkinson's disease

FEBS Letters, EarlyView.
Drosophila park mutants serve as a model for Parkinson's disease. We used this strain to investigate the connection between oxidative stress and the circadian clock mechanism. We showed that increased oxidative stress affects the physiology of pacemaker cells, disrupting their daily structural plasticity. Lack of rhythmic signaling from pacemaker cells
Kamila Zientara, Kinga Skoczek, Elzbieta Pyza, Milena Damulewicz   +3 more
wiley   +1 more source

Mediation Analysis for Probabilities of Causation

Proceedings of the AAAI Conference on Artificial Intelligence
Probabilities of causation (PoC) offer valuable insights for informed decision-making. This paper introduces novel variants of PoC-controlled direct, natural direct, and natural indirect probability of necessity and sufficiency (PNS). These metrics quantify the necessity and sufficiency of a treatment for producing an outcome, accounting for different ...
Yuta Kawakami, Jin Tian
openaire   +2 more sources

The mediating effect of self-perceived aging on social capital and depression among Chinese community-dwelling older adult: a cross-sectional study

Frontiers in Public Health
BackgroundAmid an aging society, boosting older adult social capital is crucial to meet their growing health needs. This could be an effective way to alleviate the shortage of public health resources and improve the mental health of the older adult ...
Yuguo Ye, Hui Liu, Ziming Wang, Qianwei Zhang, Shifan Yang, Lian Yang   +5 more
doaj   +1 more source

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source

Dietary inflammation and socioeconomic status mediate depression–constipation link: a cross-sectional analysis of NHANES 2005–2010

Frontiers in Nutrition
BackgroundThis study investigated the relationship between depression and constipation and examined potential mediating roles of dietary inflammatory index (DII) and socioeconomic status using data from NHANES 2005–2010.MethodsWe analyzed 12,854 adults ...
Qiulu Huang, Haifang Zhou, Mei Yang, Yilin Meng, Lina Wang   +4 more
doaj   +1 more source

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

FEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

The association between dietary fiber intake and cognitive function: mediating role of inflammatory markers

Frontiers in Nutrition
AimsCognitive impairment, frequently associated with neurodegenerative diseases such as Alzheimer's disease, may be associated with multiple factors including dietary fiber intake and inflammation.
Kaiyun Yan, Xinshuo Wang, Fengdan Wang, Baiyang Chen, Ziyu Zong, Jing Tian, Jing Zhao, Bo Li   +7 more
doaj   +1 more source

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source