Results 111 to 120 of about 22,390,894 (295)
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Understanding biodiversity effects on trophic interactions with a robust approach to path analysis
Cell Reports SustainabilitySummary: With its facility to assess causal mechanisms among multiple variables, the application of path analysis in medical, natural, and social sciences has become widespread.
Yu-Quan Wang +5 more
doaj +1 more source
THE LINK BETWEEN HUMAN DEVELOPMENT AND TAX COMPLIANCE: EVIDENCE FROM A MEDIATION ANALYSIS [PDF]
Analele Universităţii Constantin Brâncuşi din Târgu Jiu : Seria Economie, 2015 By performing mediation analysis with the state-of-the-art bootstrapping technique (95% bias-corrected and accelerated confidence interval; 5000 bootstrap resamples) on a worldwide sample pool of countries and territories, it is shown that human ...
BǍTRÂNCEA LARISSA
doaj
FEBS Letters, EarlyView.Cancer progression is regulated by the dynamic matrix code of the tumor microenvironment, which influences cellular behavior and disease development. Importantly, matrix remodeling in three‐dimensional cancer models more accurately reflects in vivo conditions compared to conventional two‐dimensional systems.
Sylvia Mangani +3 more
wiley +1 more source
ToxicsExposure to even low levels of the environmental pollutant cadmium (Cd) increases the risk of kidney damage and malfunction. The body burden of Cd at which these outcomes occur is not, however, reliably defined.
Soisungwan Satarug
doaj +1 more source
MEDIATION IN THE NORWEGIAN LAND CONSOLIDATION COURTS [PDF]
In Norway land consolidation is organized entirely within the judicial system. This paper describes how land consolidation courts work, and examines mediation activities in the courts.
Sky, Per Kare, Rognes, Jorn
core
Co-authoring new relationships at school through narrative mediation [PDF]
, 2010 The practice of narrative mediation is illustrated through a case study for its applicability to the resolution of conflict in a high school. Two boys who had been fighting are brought together by a New Zealand high school counsellor to address their ...
Winslade, John, Williams, Michael
core
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
Journal of the American Heart Association: Cardiovascular and Cerebrovascular DiseaseBackground Serum lipids are causally involved in the occurrence of atherosclerosis, but their roles in cerebral small vessel disease remain unclear. This study aimed to investigate the causal roles of lipid or apolipoprotein traits in cerebral small ...
Yi Xie +8 more
doaj +1 more source
A Class of Distribution-free Models for Longitudinal Mediation Analysis
, 2012 Thesis (Ph.D.)--University of Rochester. School of Medicine & Dentistry. Dept. of Biostatistics and Computational Biology, 2011.My thesis research focuses on developing novel statistical models and applications to address important methodological ...
Gunzler, Doug, Tu, Xin M.
core