Results 91 to 100 of about 800,077 (295)

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

The impact of humility traits on job search behavior in college graduates: the mediating role of job search clarity

Frontiers in Psychology
IntroductionThis study investigates the influence of humility traits on job search behavior among college graduates, emphasizing the mediating role of job search clarity.MethodsA total of 406 college graduates were surveyed using the Humility Scale, the ...
Wen-Qian Zou, Si-Han Wang, Tian-Yi Xu, Qing-Wen Zheng   +3 more
doaj   +1 more source

Does Nationality Influence Neutrality? The Ethical Standards and Expectations of International Mediators [PDF]

, 2016
This Comment examines how a mediator’s nationality can influence the mediating parties’ and communities’ perceptions of his neutrality and how cultural differences play a role in the ethical expectations of a cross-cultural mediator. Part I discusses the
Katsoris, Melissa
core   +1 more source

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

Plasma neurofilament light chain mediates the effect of subsyndromal symptomatic depression on cognitive decline in older adults

Frontiers in Aging Neuroscience
ObjectiveSubsyndromal symptomatic depression (SSD) is associated with an increased risk of cognitive impairment in non-demented older adults. However, the mechanism underlying this relationship remains unclear.
Chunhua Zhang, Chunhua Zhang, Bingyu Li, Kok Pin Ng, Kok Pin Ng, Guojuan Huang, Xijin Wang, Min Kong, Maowen Ba, Maowen Ba   +9 more
doaj   +1 more source

Fetal Brain Tumor Harboring a Unique ROCK1::BRAF Fusion

Pediatric Blood &Cancer, EarlyView.
Marllon Cindra Sant'Ana, Mariana Maschietto, Daniela Paz Leal, Ricardo de Santos de Oliveira, Mayara Ferreira Euzébio, Antonio Carlos dos Santos, Luciano Neder, Carlos Alberto Scrideli, Elvis Terci Valera   +8 more
wiley   +1 more source

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

Association between the dietary index for gut microbiota and metabolic syndrome: the mediating role of the dietary inflammatory index

Frontiers in Nutrition
BackgroundMetabolic syndrome (MetS) poses a huge global public health challenge. The dietary index for gut microbiota (DI-GM) measures the influence of diets on the microbiome, but its link with the odds of MetS is elusive.
Yu-Nan Han, Yong-Xiang Wang, Cheng-Yue Xiong, Lin Li, Ru-Meng Mao   +4 more
doaj   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Exploring the role of the atherogenic index of plasma as a mediator between body roundness Index and cardiovascular events in older adults: a NHANES-based study

Frontiers in Cardiovascular Medicine
BackgroundThe rising incidence of cardiovascular diseases (CVD) in the elderly highlights the need for effective preventive strategies. Recent studies suggest that obesity, through metabolic factors, contributes to the development of CVD. This study aims
Kangming Li, Kangming Li, Shizhong Chen, Shizhong Chen, Yanan Hu, Yanan Hu, Chunmei Qi, Chunmei Qi   +7 more
doaj   +1 more source