Results 91 to 100 of about 22,390,894 (295)

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

open access: yesFEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

MedModr: A free, user-friendly, browser-based open-source application for mediation, moderation, and conditional process analyses

open access: yesSoftwareX
Mediation, moderation, and conditional process analyses are widely used in health and social science research, however, existing analytical tools often present technical, financial, and accessibility barriers.
Mudasir Mohammed Ibrahim
doaj   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

open access: yesFEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa   +2 more
wiley   +1 more source

The impact of humility traits on job search behavior in college graduates: the mediating role of job search clarity

open access: yesFrontiers in Psychology
IntroductionThis study investigates the influence of humility traits on job search behavior among college graduates, emphasizing the mediating role of job search clarity.MethodsA total of 406 college graduates were surveyed using the Humility Scale, the ...
Wen-Qian Zou   +3 more
doaj   +1 more source

Causal mediation analysis with a three‐dimensional image mediator

open access: yesStatistics in Medicine
Causal mediation analysis is increasingly abundant in biology, psychology, and epidemiology studies and so forth. In particular, with the advent of the big data era, the issue of high‐dimensional mediators is becoming more prevalent. In neuroscience, with the widespread application of magnetic resonance technology in the field of brain imaging, studies
Minghao Chen, Yingchun Zhou
openaire   +3 more sources

Mediation, Walrasian Tatonement, and Negotiations as an Exchange Economy [PDF]

open access: yes
Alternative dispute resolution (ADR) procedures, such as mediation and arbitration, are becoming increasingly used to help resolve disputes in a variety of arenas. Among ADR procedures, mediation is the most utilized yet least analyzed procedure.
David Dickinson
core  

Relative Rebel Strength and the Onset and Outcome of Civil War Mediation [PDF]

open access: yes, 2013
To what extent does the relative strength of a rebel movement impact upon the likelihood of a peace settlement in civil conflict? This paper argues that relatively stronger rebels are more likely to overcome the strategic bargaining problems that can ...
Clayton, Govinda
core   +1 more source

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

open access: yesFEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee   +7 more
wiley   +1 more source

Plasma neurofilament light chain mediates the effect of subsyndromal symptomatic depression on cognitive decline in older adults

open access: yesFrontiers in Aging Neuroscience
ObjectiveSubsyndromal symptomatic depression (SSD) is associated with an increased risk of cognitive impairment in non-demented older adults. However, the mechanism underlying this relationship remains unclear.
Chunhua Zhang   +9 more
doaj   +1 more source

Modelling stem cell differentiation related processes—A practical overview for biologists

open access: yesFEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar   +4 more
wiley   +1 more source

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