Results 81 to 90 of about 178,060 (260)
An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane
FEBS Letters, EarlyView.Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa +3 more
wiley +1 more source
Causal mediation analysis with a three‐dimensional image mediator
Statistics in MedicineCausal mediation analysis is increasingly abundant in biology, psychology, and epidemiology studies and so forth. In particular, with the advent of the big data era, the issue of high‐dimensional mediators is becoming more prevalent. In neuroscience, with the widespread application of magnetic resonance technology in the field of brain imaging, studies
Minghao Chen, Yingchun Zhou
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Frontiers in MedicineBackgroundChronic obstructive pulmonary disease (COPD) is a major contributor to early mortality, high overall mortality rates, and significant healthcare costs. Based on the Life’s Essential 8 (LE8), Life’s Crucial 9 (LC9) is a new cardiovascular health
Ziming Wang, Xinyun Xie, Hongyang Gong
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The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes
FEBS Letters, EarlyView.Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga +3 more
wiley +1 more source
Mediation Analysis: A Practitioner's Guide [PDF]
Annual Review of Public Health, 2016 This article provides an overview of recent developments in mediation analysis, that is, analyses used to assess the relative magnitude of different pathways and mechanisms by which an exposure may affect an outcome. Traditional approaches to mediation in the biomedical and social sciences are described.
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Understanding biodiversity effects on trophic interactions with a robust approach to path analysis
Cell Reports SustainabilitySummary: With its facility to assess causal mechanisms among multiple variables, the application of path analysis in medical, natural, and social sciences has become widespread.
Yu-Quan Wang +5 more
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THE LINK BETWEEN HUMAN DEVELOPMENT AND TAX COMPLIANCE: EVIDENCE FROM A MEDIATION ANALYSIS [PDF]
Analele Universităţii Constantin Brâncuşi din Târgu Jiu : Seria Economie, 2015 By performing mediation analysis with the state-of-the-art bootstrapping technique (95% bias-corrected and accelerated confidence interval; 5000 bootstrap resamples) on a worldwide sample pool of countries and territories, it is shown that human ...
BǍTRÂNCEA LARISSA
doaj
FEBS Letters, EarlyView.Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
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ToxicsExposure to even low levels of the environmental pollutant cadmium (Cd) increases the risk of kidney damage and malfunction. The body burden of Cd at which these outcomes occur is not, however, reliably defined.
Soisungwan Satarug
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FEBS Letters, EarlyView.Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil +4 more
wiley +1 more source