Results 61 to 70 of about 800,077 (295)

Identification, Inference and Sensitivity Analysis for Causal Mediation Effects

, 2010
Causal mediation analysis is routinely conducted by applied researchers in a variety of disciplines. The goal of such an analysis is to investigate alternative causal mechanisms by examining the roles of intermediate variables that lie in the causal ...
Imai, Kosuke, Keele, Luke, Yamamoto, Teppei   +2 more
core   +2 more sources

A single-level random-effects cross-lagged panel model for longitudinal mediation analysis [PDF]

, 2017
Cross-lagged panel models (CLPMs) are widely used to test mediation with longitudinal panel data. One major limitation of the CLPMs is that the model effects are assumed to be fixed across individuals.
Carroll, Ian A., Chen, Po-Yi, Wu, Wei
core   +1 more source

The conduct and reporting of mediation analysis in recently published randomized controlled trials : results from a methodological systematic review [PDF]

, 2020
Objectives: To describe the methodological characteristics of mediation analyses (MAs) reported in recent randomized controlled trials (RCTs) and to propose recommendations on the planning, conduct, and reporting of MAs in practice.
Boutron, Isabelle, Superchi, Cecilia, Vansteelandt, Stijn, Vo, Tat-Thang   +3 more
core   +3 more sources

Adherence to Protocol Recommendations for Children With Wilms Tumour in Two Consecutive Studies in the United Kingdom and Ireland—Does Variation Matter?

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background and Aims Wilms tumour (WT) has excellent event‐free and overall survival (OS). However, small differences exist between countries participating in the same international study. This led us to examine variation in adherence to protocol recommendations as a potential contributing factor.
Suzanne Tugnait, R. Al‐Saadi, A. Lopez‐Cortes, K. Dzhuma, M. Oostveen, J. Brok, S. Irtan, M. Weeks, J. Bate, S. Baker, R. Williams, M. Powis, D. Saunders, O. Olsen, T. Watson, S. Shelmerdine, S. Vaidya, L. Howell, C. Duncan, G. M. Vujanic, C. Stiller, G. P. Balchin, T. Chowdhury, K. Pritchard‐Jones   +23 more
wiley   +1 more source

(Non-)Decoupled Supersymmetric Field Theories [PDF]

, 2014
We study some consequences of coupling supersymmetric theories to (super)gravity. To linear order, the couplings are determined by the energy-momentum supermultiplet.
Di Pietro, Lorenzo, Dine, Michael, Komargodski, Zohar   +2 more
core   +1 more source

Continuous‐time causal mediation analysis

Statistics in Medicine, 2019
While causal mediation analysis has seen considerable recent development for a single measured mediator (M) and final outcome (Y), less attention has been given to repeatedly measured M and Y. Previous methods have typically involved discrete‐time models that limit inference to the particular measurement times used and do not recognize the continuous ...
Jeffrey M. Albert, Youjun Li, Jiayang Sun, Wojbor A. Woyczynski, Suchitra Nelson   +4 more
openaire   +4 more sources

Evaluating the Utility of Paired Tumor and Germline Targeted DNA Sequencing for Pediatric Oncology Patients: A Single Institution Report

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Objective To evaluate the diagnostic yield and utility of universal paired tumor–normal multigene panel sequencing in newly diagnosed pediatric solid and central nervous system (CNS) tumor patients and to compare the detection of germline pathogenic/likely pathogenic variants (PV/LPVs) against established clinical referral criteria for cancer ...
Natalie Waligorski, Rebecca Ronsley, Shannon M. Stasi, Jeffrey Stevens, Erin R. Rudzinski, Christina M. Lockwood, Sarah E. S. Leary, Bonnie L. Cole, Michelle A. Ting, Vera Paulson   +9 more
wiley   +1 more source

Supersymmetry and precision data after LEP2

, 2005
We study one loop supersymmetric corrections to precision observables. Adding LEP2 e ebar --> f fbar cross sections to the data-set removes previous hints for SUSY and the resulting constraints are in some cases stronger than direct bounds on sparticle ...
Agrawal, Alessandro Strumia, Altarelli, Altarelli, Altarelli, Alvarez-Gaume, Arkani-Hamed, Barbieri, Buchbinder, Chankowski, Chankowski, Chankowski, Cho, Christian Schappacher, Dedes, Denner, Dine, Ellis, Ellis, Ellis, Gherghetta, Giudice, Giusti, Gregoire, Griest, Grifols, Grifols, Guido Marandella, Hahn, Hahn, Hahn, Hahn, Hahn, Hollik, Kane, Kuchiev, Lebedev, Martin, Nihei, Passarino, Pierce, Randall, Rattazzi, Romanino, Strumia, Weinberg   +45 more
core   +2 more sources

NRASQ61R Expression in Lymphatic Endothelial Cells Causes Enlarged Vessels, Hemorrhagic Chylous Effusions, and High Mortality in a Mouse Model of Kaposiform Lymphangiomatosis

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Kaposiform lymphangiomatosis (KLA) is an aggressive complex lymphatic anomaly. Patients exhibit malformed lymphatic vessels and often develop hemorrhagic effusions and elevated angiopoietin‐2 (Ang‐2) levels. A somatic NRAS p.Q61R (NRASQ61R) mutation has been associated with KLA.
C. Griffin McDaniel, Patricia Pastura, Joshua P. Scallan, Timothy D. Le Cras   +3 more
wiley   +1 more source

Generalized Inference for Mediation Analysis

Mathematics
Mediation analysis has a long history and its use in applied research has been increasing. Studying mediators can help improve our understanding of mechanisms relating independent and dependent variables.
Xiaoyang Ma, David P. MacKinnon, Thomas Mathew, Brian Agan, George Luta, Ionut Bebu   +5 more
doaj   +1 more source