Results 71 to 80 of about 178,060 (260)

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

The impact of humility traits on job search behavior in college graduates: the mediating role of job search clarity

Frontiers in Psychology
IntroductionThis study investigates the influence of humility traits on job search behavior among college graduates, emphasizing the mediating role of job search clarity.MethodsA total of 406 college graduates were surveyed using the Humility Scale, the ...
Wen-Qian Zou, Si-Han Wang, Tian-Yi Xu, Qing-Wen Zheng   +3 more
doaj   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Mediation Analysis with Multiple Exposures and Multiple Mediators

Statistics in Medicine
ABSTRACTA mediation analysis approach is proposed for multiple exposures, multiple mediators, and a continuous scalar outcome under the linear structural equation modeling framework. It assumes that there exist orthogonal components that demonstrate parallel mediation mechanisms on the outcome, and thus is named principal component mediation analysis ...
openaire   +3 more sources

EDITORIAL – MEDIATION ANALYSIS: ISSUES AND RECOMMENDATIONS [PDF]

Journal of Applied Structural Equation Modeling, 2018
Mumtaz Ali Memon, Jun-Hwa Cheah, T. Ramayah, Hiram Ting, Francis Chuah   +4 more
doaj   +1 more source

Plasma neurofilament light chain mediates the effect of subsyndromal symptomatic depression on cognitive decline in older adults

Frontiers in Aging Neuroscience
ObjectiveSubsyndromal symptomatic depression (SSD) is associated with an increased risk of cognitive impairment in non-demented older adults. However, the mechanism underlying this relationship remains unclear.
Chunhua Zhang, Chunhua Zhang, Bingyu Li, Kok Pin Ng, Kok Pin Ng, Guojuan Huang, Xijin Wang, Min Kong, Maowen Ba, Maowen Ba   +9 more
doaj   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Association between the dietary index for gut microbiota and metabolic syndrome: the mediating role of the dietary inflammatory index

Frontiers in Nutrition
BackgroundMetabolic syndrome (MetS) poses a huge global public health challenge. The dietary index for gut microbiota (DI-GM) measures the influence of diets on the microbiome, but its link with the odds of MetS is elusive.
Yu-Nan Han, Yong-Xiang Wang, Cheng-Yue Xiong, Lin Li, Ru-Meng Mao   +4 more
doaj   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Exploring the role of the atherogenic index of plasma as a mediator between body roundness Index and cardiovascular events in older adults: a NHANES-based study

Frontiers in Cardiovascular Medicine
BackgroundThe rising incidence of cardiovascular diseases (CVD) in the elderly highlights the need for effective preventive strategies. Recent studies suggest that obesity, through metabolic factors, contributes to the development of CVD. This study aims
Kangming Li, Kangming Li, Shizhong Chen, Shizhong Chen, Yanan Hu, Yanan Hu, Chunmei Qi, Chunmei Qi   +7 more
doaj   +1 more source