Results 121 to 130 of about 6,996 (305)
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
Theatre without theatres: Investigating access barriers to mediatized theatre and digital liveness during the covid-19 pandemic. [PDF]
Poetics (Amst), 2023 Brilli S, Gemini L, Giuliani F.
europepmc +1 more source
Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Revue Française des Sciences de l’Information et de la CommunicationSince its launch, the French feminist collective #NousToutes has been characterized by the “centrality” accorded to communication. In addition to enabling it to organize its activist work, the collective uses digital networks to communicate about its ...
Irène Despontin Lefèvre
doaj +1 more source
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
CommunicationThe authors look at some strategies for using media space in connection with religious discourse. Brazil has provided a particularly interesting opportunity to observe the return of a religious discourse in the discussion space opened by mediatization ...
Ângela Cristina Salgueiro Marques +2 more
doaj +1 more source
When scientific experts come to be media stars: An evolutionary model tested by analysing coronavirus media coverage across Italian newspapers. [PDF]
PLoS One, 2023 Neresini F +6 more
europepmc +1 more source
The search for the Jew's gene : science, spectacle, and the ethnic other [PDF]
, 2009 This paper considers the collision of spectacle, science, and racial-ethnic identifications in the contemporary scientific search for a "Jewish gene." It aims not so much to distinguish the "line between ‘real’ and ‘fabled’ aspects of the Jew" (as ...
Steinberg, Deborah Lynn
core
Molecular Oncology, EarlyView.Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee +8 more
wiley +1 more source