Results 111 to 120 of about 5,004,571 (383)

Mediating Climate, Mediating Scale [PDF]

Humanities, 2019
Climate communication is seemingly stuck in a double bind. The problem of global warming requires inherently trans-scalar modes of engagement, encompassing times and spaces that exceed local frames of experience and meaning. Climate media must therefore negotiate representational extremes that risk overwhelming their audience with the immensity of the ...
openaire   +2 more sources

Peptide‐based ligand antagonists block a Vibrio cholerae adhesin

FEBS Letters, EarlyView.
The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang, Grace Du, Charity Yongo‐Luwawa, Angelina Lu, Brett Kinrade, Kim Munro, Karl E. Klose, William D. Lubell, Peter Davies, Shuaiqi Guo   +9 more
wiley   +1 more source

Regulatory functions of the Mediator kinases CDK8 and CDK19

Transcription, 2018
The Mediator-associated kinases CDK8 and CDK19 function in the context of three additional proteins: CCNC and MED12, which activate CDK8/CDK19 kinase function, and MED13, which enables their association with the Mediator complex.
Charli B. Fant, D. Taatjes
semanticscholar   +1 more source

Axion mediation

Journal of High Energy Physics, 2013
32 pages, 3 figures, references added, minor ...
Baryakhtar, M, Hardy, E, March-Russell, J   +2 more
openaire   +3 more sources

Interplay between circadian and other transcription factors—Implications for cycling transcriptome reprogramming

FEBS Letters, EarlyView.
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley   +1 more source

Albumin: a mediator of the association between serum calcium and triglyceride-glucose index among Chinese individuals with osteoporotic fractures

Frontiers in Endocrinology
BackgroundOsteoporotic fractures (OPFs) are a major global health concern, affecting nearly 200 million individuals worldwide. Notably, patients with type 2 diabetes mellitus (T2DM) face a heightened fracture risk, even when bone mineral density (BMD) is
Jia-qi Liang, Jia-qi Liang, Jian Xu, Jian Xu, Yan Cao, Yin-lin Wei, Guo-ji Lin, Guo-ji Lin, Jian Jin, Chong Li, Chong Li, Ke Lu, Ke Lu   +12 more
doaj   +1 more source

Introducing Dynamic Behavior in Amalgamated Knowledge Bases

, 2002
The problem of integrating knowledge from multiple and heterogeneous sources is a fundamental issue in current information systems. In order to cope with this problem, the concept of mediator has been introduced as a software component providing ...
Bertino, Elisa, Catania, Barbara, Perlasca, Paolo   +2 more
core   +2 more sources

Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer

FEBS Letters, EarlyView.
Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani, Noemi E. Nwosu, Viktoria Gocke, Müge Kasanmascheff, Hannes Mutschler   +4 more
wiley   +1 more source

Mediator as a Profession Incorporated into the System of Common Courts – Civil Mediation Practice in the Light of Recent Changes

Studia Iuridica Lublinensia, 2018
The article is an attempt to examine the results of the amendments, which have been introduced to civil procedure and to mediation law since the 1st January 2016. Mediation corresponds with the nature of private law and in many other Western countries it
Anna Kalisz
doaj   +1 more source

Endocannabinoid Signaling Mediates Cocaine-Induced Inhibitory Synaptic Plasticity in Midbrain Dopamine Neurons [PDF]

, 2008
Bin Pan, Cecilia J. Hillard, Qing-song Liu   +2 more
openalex   +1 more source