Results 61 to 70 of about 29,948 (269)

The role of histone modifications in transcription regulation upon DNA damage

FEBS Letters, EarlyView.
This review discusses the critical role of histone modifications in regulating gene expression during the DNA damage response (DDR). By modulating chromatin structure and recruiting repair factors, these post‐translational modifications fine‐tune transcriptional programmes to maintain genomic stability.
Angelina Job Kolady, Siyao Wang
wiley   +1 more source

MEDICAL AID IN DYING: DOES POLICY PREVENT SUFFERING AT THE END OF LIFE? [PDF]

Innov Aging, 2022
Todd Becker, Nancy Kusmaul, Allison Gibson, Cara Wallace   +3 more
europepmc   +3 more sources

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

Hard Choices: How Does Injustice Affect the Ethics of Medical Aid in Dying? [PDF]

, 2023
Brent M. Kious
openalex   +1 more source

Flaws in advance directives that request withdrawing assisted feeding in late-stage dementia may cause premature or prolonged dying

BMC Medical Ethics, 2022
Background The terminal illness of late-stage (advanced) Alzheimer’s and related dementias is progressively cruel, burdensome, and can last years if caregivers assist oral feeding and hydrating. Options to avoid prolonged dying are limited since advanced
Stanley A. Terman, Karl E. Steinberg, Nathaniel Hinerman   +2 more
doaj   +1 more source

Mechanisms of parasite‐mediated disruption of brain vessels

FEBS Letters, EarlyView.
Parasites can affect the blood vessels of the brain, often causing serious neurological problems. This review explains how different parasites interact with and disrupt these vessels, what this means for brain health, and why these processes matter. Understanding these mechanisms may help us develop better ways to prevent or treat brain infections in ...
Leonor Loira, Sílvia Arroz‐Madeira, Cláudio A. Franco, Sara Silva Pereira   +3 more
wiley   +1 more source

How to talk with dying patients and their families after disasters and humanitarian crises: a review of available tools and guides for disaster responders

Journal of International Humanitarian Action, 2019
In responding to those affected by sudden onset disasters and chronic humanitarian crises, disaster responders and humanitarian aid workers will face the challenge of caring for dying patients.
B. R. Daubman, H. Cranmer, L. Black, A. Goodman   +3 more
doaj   +1 more source

Perspectives, perceived self-efficacy, and preparedness of newly qualified physicians’ in practising palliative care—a qualitative study

BMC Palliative Care, 2022
Background Dealing with life-limiting illnesses, death, dying and grief, is uncharted territory for medical graduates. It is a field that is heavily influenced by cultural, religio-spiritual and social factors.
Nwabata Oji, Tonia Onyeka, Olaitan Soyannwo, Piret Paal, Frank Elsner   +4 more
doaj   +1 more source

Quebec physicians' perspectives on medical aid in dying for incompetent patients with dementia. [PDF]

Can J Public Health, 2018
Bravo G, Rodrigue C, Arcand M, Downie J, Dubois MF, Kaasalainen S, Hertogh CM, Pautex S, Van den Block L, Trottier L.   +9 more
europepmc   +3 more sources

PICALM::MLLT10 translocated leukemia

FEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen, Antonia C. Nakatsugawa, Natalie Barton, Henry Haines, Gary S. Stein, Janet L. Stein, Daniel S. Wechsler, Jessica L. Heath   +7 more
wiley   +1 more source