Results 91 to 100 of about 19,687,691 (268)
An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes
FEBS Letters, EarlyView.GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg +14 more
wiley +1 more source
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Research Progress on the Application of Large Language Model-based Intelligent Medical Assistants
Xiehe Yixue ZazhiLarge language models (LLMs), represented by ChatGPT, have garnered significant attention due to their powerful capabilities in understanding and generating human language.
ZHANG Yuchen +3 more
doaj +1 more source
Tree-based generational feature selection in medical applications
Procedia Computer Science, 2019 Abstract In many knowledge discovery experiments feature selection is obvious initial part. In the paper, some attempt to tree-based generational feature selection applications in medical data analysis is presented. This approach devotes to application of classification tree algorithm to estimate importance of attributes extracted from structure of ...
openaire +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Medical College building, 1914
, 1914 This glass lantern slide features a ground view of the Medical College Building of the Medical College of the State of South Carolina in ...
Medical College of South Carolina (1952-1969). Department of Medical Illustration
core
Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network
FEBS Letters, EarlyView.Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley +1 more source
Frontiers in MedicineIntroductionThe integration of artificial intelligence technology into healthcare education has been hampered by a number of difficulties. This study aimed to investigate the faculty’s familiarity and perception towards AI applications in medical ...
Eidan M. Al Zahrani +6 more
doaj +1 more source
, 1951 This glass lantern slide features an aerial view of the Medical Center campus of the Medical College of South Carolina in ...
Medical College of South Carolina (1952-1969). Department of Medical Illustration
core
Molecular Oncology, EarlyView.In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge +17 more
wiley +1 more source