Results 81 to 90 of about 2,015,410 (353)

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

The fidelity of dynamic signaling by noisy biomolecular networks [PDF]

, 2013
This is the final version of the article. Available from Public Library of Science via the DOI in this record.Cells live in changing, dynamic environments.
A Eldar, A Hilfinger, AH Brivanlou, B Hu, CG Bowsher, CG Bowsher, CG Bowsher, Clive G. Bowsher, CP Barnes, E Libby, F Tostevin, F Tostevin, G Balázsi, Jason M. Haugh, JC Anderson, L Steidler, M Thattai, M Voliotis, Margaritis Voliotis, N Rosenfeld, P Hersen, P Purnick, PB Detwiler, Peter S. Swain, PS Swain, R Cheong, S Tănase-Nicola, T Erdmann, T Shaw, TJ Kobayashi, TJ Perkins, V Shahrezaei, V Shahrezaei, W Bialek, W de Ronde, YT Maeda   +35 more
core   +5 more sources

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

DeepSeek Empowers General Medicine: Potential Application and Prospect [PDF]

Zhongguo quanke yixue
In January 2025, DeepSeek launched its reasoning model DeepSeek-R1, characterized by open-source accessibility, cost-effectiveness, and strong reasoning capabilities, thus showing significant potential for applications within the medical domain.
YAN Wenxin, LIU Jue, LIANG Wannian
doaj   +1 more source

Vital Sign Ontology [PDF]

, 2011
We introduce the Vital Sign Ontology (VSO), an extension of the Ontology for General Medical Science (OGMS) that covers the consensus human vital signs: blood pressure, body temperature, respiratory rate, and pulse rate.
Arabandi, Sivaram, Brochhausen, Mathias, Goldfain, Albert, Hogan, William R., Smith, Barry   +4 more
core  

Application of Artificial Intelligence Generated Content in Medical Examinations

Advances in Medical Education and Practice
As the rapid development of large language model, artificial intelligence generated content (AIGC) presents novel opportunities for constructing medical examination questions. However, it is unclear about the way of effectively utilizing AIGC for designing medical questions.
Rui Li, Tong Wu
openaire   +4 more sources

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

SNOMED CT standard ontology based on the ontology for general medical science [PDF]

, 2018
Background: Systematized Nomenclature of Medicine—Clinical Terms (SNOMED CT, hereafter abbreviated SCT) is acomprehensive medical terminology used for standardizing the storage, retrieval, and exchange of electronic healthdata.
El-Sappagh, Shaker, Farman, Ali, Franda, Francesco, Kwak, Kyung-Sup   +3 more
core   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

APLICACIONES BIOMÉDICAS DE POLIURETANOS

Química Nova
Polyurethanes (PUs) are generating increasing interest in the biomedical field due to its characteristic properties. The objective of this article was review general properties of PUs and related with their biomedical applications, also to show the ...
Yomaira L. Uscategui, Luis E. Díaz, Manuel F. Valero   +2 more
doaj   +1 more source