Results 81 to 90 of about 678,602 (266)

A systematic review on the generative AI applications in human medical genetics

Frontiers in Genetics
Although traditional statistical techniques and machine learning methods have contributed significantly to genetics and, in particular, inherited disease diagnosis, they often struggle with complex, high-dimensional data, a challenge now addressed by state-of-the-art deep learning models. Large language models (LLMs), based on transformer architectures,
Anton Changalidis, Yury A Barbitoff, Yulia A Nasykhova, Andrey S. Glotov   +3 more
openaire   +3 more sources

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

MedVH: Toward Systematic Evaluation of Hallucination for Large Vision Language Models in the Medical Context

Advanced Intelligent Systems
Large vision language models (LVLMs) have achieved superior performance on natural image and text tasks, inspiring extensive fine‐tuning research. However, their robustness against hallucination in clinical contexts remains understudied.
Zishan Gu, Jiayuan Chen, Fenglin Liu, Changchang Yin, Ping Zhang   +4 more
doaj   +1 more source

Medical faculty members’ perception of smartphones as an educational tool

BMC Medical Education, 2019
Background The rapid adoption of modern technology has changed many aspects of our life and communication; it has the power to influence and change the way we teach, learn and practice different types of professions mainly teaching and health care ...
Oqab Jabali, Munther Saeedi, Ghada Shbeitah, Abed Alkarim Ayyoub   +3 more
doaj   +1 more source

A role for eIF5A in translational control of stress‐inducible proteins in multiple myeloma cell lines

Molecular Oncology, EarlyView.
Loss of eIF5A rewires thapsigargin‐mediated endoplasmic reticulum stress responses in multiple myeloma cells by selective translation of mRNA transcripts, consequently dampening thapsigargin‐induced unfolded protein response (UPR) activation and shifting the balance from induction of apoptosis toward cell survival and proliferation.
Demi Both, Ingrid A. M. Derks, Raphaël Vanleyssem, Marine Leclercq, Najla El Hachem, Pierre Close, Eric Eldering, Marco Vincent Haselager   +7 more
wiley   +1 more source

Leveraging foundation and large language models in medical artificial intelligence

Chinese Medical Journal
. Recent advancements in the field of medical artificial intelligence (AI) have led to the widespread adoption of foundational and large language models.
Io Nam Wong, Olivia Monteiro, Daniel T. Baptista-Hon, Kai Wang, Wenyang Lu, Zhuo Sun, Sheng Nie, Yun Yin, Jing Ni   +8 more
doaj   +1 more source

Regulation of the lncRNA NEAT1 by p53‐ΔNp63 crosstalk modulates the DNA damage response and therapeutic efficacy in HNSCC

Molecular Oncology, EarlyView.
In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico, Veronica La Banca, Silvia D'Amico, Stefano Scalera, Sara Nicolai, Angelo Peschiaroli   +5 more
wiley   +1 more source

Construction and application of medication reminder system: intelligent generation of universal medication schedule

BioData Mining
Abstract Background Patients with chronic conditions need multiple medications daily to manage their condition. However, most patients have poor compliance, which affects the effectiveness of treatment. To address these challenges, we establish a medication reminder system for the intelligent generation of universal ...
Hangxing Huang, Lu Zhang, Yongyu Yang, Ling Huang, Xikui Lu, Jingyang Li, Huimin Yu, Shuqiao Cheng, Jian Xiao   +8 more
openaire   +4 more sources

Extracellular matrix remodeling and immune reprogramming drive residual tumor progression of liver cancer after incomplete microwave ablation

Molecular Oncology, EarlyView.
Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu, Yubei He, Nikolaus Berndt, Michael Mülleder, Kathrin Textoris‐Taube, Jing Guo, Matthias Stechele, Justus Ramtke, Shraga Nahum Goldberg, Lynn Jeanette Savic   +9 more
wiley   +1 more source

The Biomedical Limitations of Magnetic Nanoparticles and a Biocompatible Alternative in the Form of Magnetotactic Bacteria

Journal of Functional Biomaterials
Nanotechnology has an increasing impact and a great potential in various biological and medical applications. Magnetic nanoparticles (MNPs) stand out for their unique properties, a reason why they have a varied spectrum of applicability in different ...
Natalia L. Paul, Rahela Carpa, Rodica Elena Ionescu, Catalin Ovidiu Popa   +3 more
doaj   +1 more source