Results 91 to 100 of about 40,507 (289)

Exploring attitudes toward physician-assisted death in patients with life-limiting illnesses with varying experiences of palliative care: a pilot study

open access: yesBMC Palliative Care, 2018
Background On February 6th, 2015, the Supreme Court of Canada ruled that competent adults suffering intolerably from a grievous and irremediable medical condition have the right to the assistance of a physician in ending their own lives, an act known as ...
Patricia Hizo-Abes   +2 more
doaj   +1 more source

Preparing Nurses for Medical-Assistance in Dying: The Role of Comprehensive Education and Training

open access: yes
Medical-assistance in dying (MAID) is a process in which a physician prescribes lethal medications that the consenting patient will self-administer with the intention of ending their life. By April 2024, medical-assistance in dying was legal in 10 states
O\u27Reilly, Keira
core   +1 more source

Clinical Trial Implications for Study Participants Accessing Medical Assistance in Dying

open access: yes, 2019
The legalization of medical assistance in dying (maid) in June 2016 expanded options for end-of-life care in Canada [...
D. Selby, S. Bean, Blair Henry, Y. J. Ko
core   +1 more source

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

open access: yesMolecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov   +3 more
wiley   +1 more source

Assisted death in eating disorders: a systematic review of cases and clinical rationales

open access: yesFrontiers in Psychiatry
BackgroundAssisted dying for reasons solely related to an eating disorder (ED) has occurred in multiple countries, including those which restrict the practice to individuals with a terminal condition.
Chelsea Roff, Catherine Cook-Cottone
doaj   +1 more source

Who Is Eligible for Voluntary Assisted Dying? Nine Medical Conditions Assessed Against Five Legal Frameworks

open access: yes, 2022
Eligibility criteria in voluntary assisted dying legislation determine access to assistance to die. This article undertakes the practical exercise of analyzing whether each of the following nine medical conditions can provide an individual with access to
Hewitt, Jayne   +17 more
core   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

open access: yesMolecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau   +8 more
wiley   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

open access: yesMolecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu   +10 more
wiley   +1 more source

Assistance in Dying: A Comparative Look at Legal Definitions

open access: yes, 2022
Euthanasia, assisted suicide, medical assistance in dying, death with dignity: these and many other different terms are used around the world to capture various types of assistance in dying.
Cavalli, Stefano   +3 more
core   +1 more source

Le jugement éthique dans l’évaluation des demandes d’aide médicale à mourir au Canada et au Québec : que nous apprennent les autres juridictions ?

open access: yesSociologies, 2023
This paper concerns the ethical judgment that lies at the heart of assessing requests for Medical Assistance in Dying (MAID) in Canada and Quebec, namely is it ethically right to help the person requesting assistance to end his or her life?
Mona Gupta, Samuel Blouin
doaj  

Home - About - Disclaimer - Privacy