Results 81 to 90 of about 225,694 (302)

Ethical arguments against coercing provider participation in MAiD (medical assistance in dying) in Ontario, Canada

BMC Medical Ethics, 2020
It has historically been a crime in Canada to provide assistance to someone in ending their own life, however, this paradigm was inverted in 2015 when the Supreme Court of Canada (SCC) ruled that restrictions on this practice, within certain defined ...
Travis Carpenter, Lucas Vivas
doaj   +1 more source

Palliative care for people with dementia living at home: a systematic review of interventions [PDF]

, 2019
Background: The European Association for Palliative Care White Paper defined optimal palliative care in dementia based on evidence and expert consensus. Yet, we know little on how to achieve this for people with dementia living and dying at home.
Bunn, Frances, Goodman, Claire, Lynch, Jennifer, Miranda, Rose, Van den Block, Lieve   +4 more
core   +3 more sources

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source

End-stage head and neck cancer: coping mechanism [PDF]

, 2017
Coping mechanisms are patients’ means of adapting to stressful situations and involve psychological and physical changes in behavior. Patients adapt to head and neck cancer in a variety of ways.
Berteşteanu, Serban V.G., Paun, Oana, Popescu, Bogdan, Scăunaşu, Razvan V.   +3 more
core   +3 more sources

The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes

FEBS Letters, EarlyView.
Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga, Toshiki Takahashi, Akiko Kuma, Hiroyuki Kawahara   +3 more
wiley   +1 more source

Medical Assistance in Dying and its extensions in Canada

Health Reform Observer - Observatoire des Réformes de Santé
Medical Assistance in Dying (MAiD) was allowed in 2016 through an amendment of the Criminal Code, prompted by a decision of the Supreme Court of Canada. Initially, MAiD was open for patients with a grievous and irremediable condition and whose death was
Michel Grignon, Yukiko Asada, Leslie-Anne Campbell, Scott Y.H. Kim, Nathan K. Smith   +4 more
doaj   +1 more source

Key Topics on End-of-Life Care for African Americans [PDF]

, 2006
Racial classifications of human populations are politically and socially determined. There is no biological or genetic basis for these racial classifications. Health behaviors may be influenced by culture and poverty.
Bernice Harper, Bethsheba Johnson, Camilla Hudson, Diane Deese, Fay Burrs, Gloria Ramsey, Gwendolyn London, Harold Freeman, Jeremiah Wright, Jr., Joseph Dancy, Jr., Karla Holloway, Kelvin Calloway, LaVera Crawley, Michelle Grant Ervin, Myra Christopher, Paul Smith, Pernessa Seele, Richard Payne, Robert Washington, Rosalyn Priester, Sharon R. Latson, Skaykh Ibrahim Abdul-Malik, William Johnson, Willie Davis   +23 more
core  

Early identification of and proactive palliative care for patients in general practice, incentive and methods of a randomized controlled trial [PDF]

, 2016
BACKGROUND According to the Word Health Organization, patients who can benefit from palliative care should be identified earlier to enable proactive palliative care.
Engels, Yvonne, Galesloot, Cilia, Groot, Marieke, Prins, Judith, Thoonsen, Bregje, van Weel, Chris, Verhagen, Stans, Vissers, Kris   +7 more
core   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Euthanizing people who are 'tired of life' [PDF]

, 2017
In Belgium and the Netherlands, a debate is developing about people who express a desire to end their lives although they do not suffer from an incurable, life-threatening disease.
Cohen-Almagor, Raphael
core   +1 more source