Results 161 to 170 of about 113,643 (217)

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

A Compact Three-Rotor VTOL Development for Medical Drug Transfer

Electrica
Kursat Cicin, Ali Kankaya, Fatma Yalcinkaya, Hediye Orhan, Sena Turker, Ilknur Keskin, Enes Efe, Emrehan Yavsan   +7 more
doaj   +1 more source

Developing medical schools

Academic Medicine, 1967
openaire   +3 more sources

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Antiepileptic Medications in Development

DICP, 1991
Recently, there has been an increase in the research devoted to the study of investigational antiepileptic medications. This has led to extensive clinical trials of several new compounds. This review focuses on four of these antiepileptic medications in development: felbamate, gabapentin, lamotrigine, and vigabatrin.
N M, Graves, I E, Leppik
openaire   +2 more sources

Medications development: Successes and challenges

Pharmacology & Therapeutics, 2005
The National Institute on Drug Abuse has funded a medications program that has concentrated on the development of medications for opiate and cocaine dependence. Levomethadyl acetate (LAAM) and buprenorphine and buprenorphine/naloxone sublingual tablets were developed in conjunction with pharmaceutical partners and approved by the Food and Drug ...
Frank, Vocci, Walter, Ling
openaire   +2 more sources

Medical and medical-technological developments

1987
The amazing strides in medicine and social facilities during the last century, manifested in better health care facilities, hygiene, vaccination, the introduction of antibiotics etc., have had the effect of doubling life expectancy at birth in the industrialized countries. 1)
C. F. Hollander, H. A. Becker
openaire   +1 more source

Medical device development

2009 Annual International Conference of the IEEE Engineering in Medicine and Biology Society, 2009
The development of a successful medical product requires not only engineering design efforts, but also clinical, regulatory, marketing and business expertise. This paper reviews items related to the process of designing medical devices. It discusses the steps required to take a medical product idea from concept, through development, verification and ...
openaire   +2 more sources

The development of medical sects

Journal of Religion and Health, 1983
There exist a number of studies that demonstrate a parallel between secular and transcendental movements. A useful exercise is to look at the development of medicine and compare the origin and development of medical sects with sects that we would more normally associate with religious development.
openaire   +2 more sources