Results 51 to 60 of about 454,812 (304)

Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma

Molecular Oncology, EarlyView.
Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra, Lucca Paolo Hsu Helmich, Daniel Rodrigues de Bastos, Laura Sichero, Patrícia Savio de Araujo‐Souza, Fabio Passetti, Luisa Lina Villa   +6 more
wiley   +1 more source

1st EFORT European Consensus “Medical & Scientific Research Requirements for the Clinical Introduction of Artificial Joint Arthroplasty Devices”: Background, Delphi Methodology & Consensus process

EFORT Open Reviews, 2023
The objectives of the 1st EFORT European Consensus on ‘Medical and Scientific Research Requirements for the Clinical Introduction of Artificial Joint Arthroplasty Devices’ were foremost to focus on patient safety by establishing performance requirements ...
Thomas M Grupp, Sabine Rusch, Philippe Massin, Ashley Blom, Eduardo Garcia-Rey, Luca Cristofolini, Dennis Janssen, Bernd Grimm, Alexander Giurea, Marcus Jäger, Francesco Siccardi, Søren Overgaard   +11 more
doaj   +1 more source

Religion and Medicine: Why does religion play a role in medical regulation? [PDF]

, 2012
A comparison of the treatment of FDA regulation of religious devices with other intersections between general regulatory schemes and religious freedom.
Anonymous, Anonymous
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Pioglitazone plus (−)‐epigallocatechin gallate: a novel approach to enhance osteogenic performance in aged bone marrow mesenchymal stem cells

FEBS Open Bio, EarlyView.
Aged human bmMSCs are seeded in the scaffold. Osteoblastic induction can slightly increase cell's bone‐forming activity to produce bone‐like tissues, shown as the sporadic xylenol orange‐stained spots (the lower left image). Notably, pioglitazone plus EGCG co‐treatment dramatically increases cell's bone‐forming activity and bone‐like tissue production (
Ching‐Yun Chen, Jia‐Ci Jhang, Chun‐Yi Peng, Quốc Cường Nguyễn, Feng‐Huei Lin, Hung‐Ming Wu, Shankung Lin   +6 more
wiley   +1 more source

Regulating Cochlear Implants: The Legal Response to a Scientific and Cultural Revolution [PDF]

, 2012
This paper is a case study on the cochlear implant device. The inquiry will explore the important aspects of the device's intended use, its legal regulation, and its moral impact.
Mystal, Elie
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Digital twins to accelerate target identification and drug development for immune‐mediated disorders

FEBS Open Bio, EarlyView.
Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Medical device research update after the adoption of the EU legislation (MDR)

REC: Interventional Cardiology (English Ed.)
Despite the 2017 update to European medical device regulation and its entry into force in 2021, many doubts persist about its real-world application in medical device (MD) research in Spain.
Jon Zubiaur, José Ramón Rumoroso Cuevas, M. Concepción Rodríguez Mateos, Gloria Hernández, Iciar Alfonso Farnós, María Aláez, Sara Pich, Jordi Martorell, Emilio Paredes, Alejandro Escario, Pedro P. Fernández Rivero, Eduardo Jiménez-Carles, Armando Pérez de Prado   +12 more
doaj   +1 more source

Which computable biomedical knowledge objects will be regulated? Results of a UK workshop discussing the regulation of knowledge libraries and software as a medical device

Learning Health Systems, 2023
Introduction To understand when knowledge objects in a computable biomedical knowledge library are likely to be subject to regulation as a medical device in the United Kingdom.
Jeremy C. Wyatt, Philip Scott, Johan Ordish, Matthew South, Mark Thomas, Caroline Jones, Sue Lacey‐Bryant, workshop participants   +7 more
doaj   +1 more source

"Regulating Healthcare Technologies and Medical Supplies: A Comparative Overview" [PDF]

, 1995
A complex relationship exists among EU regulations, current national practices and rules, institutional capacities to implement regulatory adjustments and the legacy of past health and regulatory policy and traditions.
Altenstetter, Christa.
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