Results 91 to 100 of about 8,468,863 (266)

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Associations of adherence to a healthy sleep pattern with the dementia risk in the UK biobank

Alzheimer’s Research & Therapy
Background Existing evidence highlights associations between sleep behaviors and dementia risk; however, the impact of adhering to a healthy sleep pattern on dementia risk remains unclear.
Tao Wei, Jie Chang, Yiwei Zhao, Aonan Li, Wei Sun, Xiaoduo Liu, Hongjia Liu, Yi Xing, Zhibin Wang, Yi Tang   +9 more
doaj   +1 more source

Prediction of Maternal Morbidity and Mortality Risk Among Women with Medical Disorders Presenting to Emergency Obstetric care (EMOC): A Prospective Observational Study. [PDF]

J Obstet Gynaecol India, 2023
Divya MB, Dasari P.
europepmc   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Mapping aggressive behaviors and testosterone among schizophrenia patients in acute stage

Schizophrenia
Testosterone play an important role in schizophrenia, particularly for impulsive aggressive behaviors. However, there is still unclear how the neurobiological basis and correlates of these risk factors in schizophrenia patients.
Meng-Han Zhang, Jing Zhang, Hong Cai, Yi Liu, Tian Han, Yi-Fan Wang, Juan Li, Xiao-meng Xie, Xiao Ji   +8 more
doaj   +1 more source

The prevalence and clinical correlates of medical disorders comorbidities in patients with bipolar disorder. [PDF]

BMC Psychiatry, 2022
Wang Z, Li T, Li S, Li K, Jiang X, Wei C, Yang L, Cao H, Li S, Li J.   +9 more
europepmc   +1 more source

Translophagy—A potential link between autophagy impairment and translational errors

FEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk, Gailing Ma, Robin Antrobus, Diego Manni, Marco Trevisan‐Herraz, Mustafa Khwaja, Max Brown, Gavin D. Richardson, Masaaki Komatsu, Daniel Erskine, Viktor I. Korolchuk, Tetsushi Kataura   +11 more
wiley   +1 more source

Association of hypertension and depression with mortality: an exploratory study with interaction and mediation models

BMC Public Health
Background The association of hypertension and depression with mortality has not been fully understood. We aimed to explore the possible independent or joint association of hypertension and depression with mortality.
Huanhuan Huang, Fanchao Meng, Yanjie Qi, Xiuping Yan, Junhui Qi, Yuanzhen Wu, Yiwei Lin, Xu Chen, Fan He   +8 more
doaj   +1 more source

Correction to: The prevalence and clinical correlates of medical disorders comorbidities in patients with bipolar disorder. [PDF]

BMC Psychiatry, 2022
Wang Z, Li T, Li S, Li K, Jiang X, Wei C, Yang L, Cao H, Li S, Li J.   +9 more
europepmc   +1 more source

Structural and biochemical analysis of a B12 superbinder

FEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices, Jacob J. Whittaker, Dirk J. Slotboom, Albert Guskov   +3 more
wiley   +1 more source