Results 91 to 100 of about 5,285,111 (395)

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

Cis‐regulatory and long noncoding RNA alterations in breast cancer – current insights, biomarker utility, and the critical need for functional validation

Molecular Oncology, EarlyView.
The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués, Aracele Martinez‐Mendez, John Crown, Alex Eustace   +3 more
wiley   +1 more source

Assessment of Knowledge Regarding the Identification of Common Medical Emergencies and Prehospital Care Among Postgraduate Students at a Selected College in Bengaluru

RGUHS Journal of Nursing Sciences
Background Common medical emergencies such as chest pain stroke cardiac arrest seizures severe bleeding choking and burns are often life-threatening and frequently occur in both public ...
Mamata N
doaj   +1 more source

Peacetime and Epidemic Combination Medical Materials Reserve System for Public Health Emergencies

中国工程科学, 2022
 Establishing a medical materials reserve system that integrates normal time with emergencies is crucial for promoting the medical materials support ability and improving the emergency management system in China in case of public health emergencies. This
Cai Jianping, Wang Jing
doaj   +1 more source

Simulation-Based Medical Emergencies Education for Dental Students: A Three-Year Evaluation.

Journal of Dental Education, 2019
This aim of this study was to develop and evaluate a simulation program for dental students to supplement a lecture-based medical emergencies course. Students' self-reported knowledge, experience, confidence, and ability regarding medical emergencies ...
K. Marti, G. Sandhu, L. Aljadeff, Rachel Greene, Amy B Lesch, J. Le, H. Pinsky, D. Rooney   +7 more
semanticscholar   +1 more source

Strength through diversity: how cancers thrive when clones cooperate

Molecular Oncology, EarlyView.
Intratumor heterogeneity can offer direct benefits to the tumor through cooperation between different clones. In this review, Kuiken et al. discuss existing evidence for clonal cooperativity to identify overarching principles, and highlight how novel technological developments could address remaining open questions.
Marije C. Kuiken, Maartje Witsen, Emile E. Voest, Krijn K. Dijkstra   +3 more
wiley   +1 more source

Medical emergencies in dental hygienists’ practice

Medicine, 2019
Dental hygienists in Poland work in various settings, including public health care institutions, private dental practices, dental clinics, kindergartens, and schools.
J. Smereka, M. Aluchna, Alicja Aluchna, Marcin Puchalski, P. Wroblewski, I. Chęciński, Marcin Leśkiewicz, L. Szarpak   +7 more
semanticscholar   +1 more source

Ethical issues associated with in-hospital emergency from the medical emergency team's perspective: a national survey [PDF]

, 2016
Medical Emergency Teams (METs) are frequently involved in ethical issues associated to in-hospital emergencies, like decisions about end-of-life care and intensive care unit (ICU) admission.
ALAMPI, DANIELA, Borga, S, Cabrini, L, Giannini, A, Landoni, G, Luchetti, M, Mazzon, D, Minoja, G, Pellis, T, Pintaudi, M, Radeschi, G, Ristagno, G, Semeraro, F, Troiano, H   +13 more
core  

European emergency coordination. ZEI Discussion Paper C259 2020 [PDF]

, 2020
The European elections in 2019 sent two messages. Firstly, Europe is stronger than what its opponents thought it would be. Despite major challenges like Brexit and migration, the results of the election demonstrated strong European cohesion.
Stylianides, Christos
core  

Perspectives in educating molecular pathologists on liquid biopsy: Toward integrative, equitable, and decentralized precision oncology

Molecular Oncology, EarlyView.
Liquid biopsy enables minimally invasive, real‐time molecular profiling through analysis of circulating biomarkers in biological fluids. This Perspective highlights the importance of training pathologists through integrative educational programs, such as the European Masters in Molecular Pathology, to ensure effective and equitable implementation of ...
Marius Ilié, Umberto Malapelle, Catherine Alix‐Panabières, Claus Lindbjerg Andersen, Sandra Chlebowski, Vivien Lake, Caroline Lacoux, Virginie Lespinet‐Fabre, Olivier Bordone, Simon Heeke, Christophe Bontoux, Ellen Heitzer, Klaus Pantel, Paul Hofman   +13 more
wiley   +1 more source